Molecular and Integrative Cystic Fibrosis Research Centre

About

Welcome to the Molecular and Integrative Cystic Fibrosis (miCF) Research Centre. Our overall goal is to be at the forefront of translational research bridging between omic data to functional characterization and applied research in disease states (such as cystic fibrosis, asthma and COPD), and pharmacokinetics. Our lab is interested in understanding the processes at the cellular and molecular level in regulation of epithelial cell biology and how the breakdown of this regulation leads to pathogenesis of disease such as Cystic Fibrosis (CF).

We are based at the Westfield Research Laboratories in Sydney Children's Hospital in Randwick, the second largest Paediatric hospital in the State of NSW. The Laboratory consists of PC2 wet laboratory spaces and associated office space. We have a range of specialized equipment to facilitate our research efforts. The Laboratory houses the Digital and Confocal Microscopy Unit and multiple ultra-freezers and Liquid Nitrogen tanks that are used for BioBanking services. The lab is well-equipped and configured to support a wide range of experiments making it possible to perform cytogenetic, epigenetics, and molecular and cell biology research.

We have access to the world class Genomics (Ramaciotti Centre for Genomics) and Proteomics facilities (Bioanalytical Mass Spectrometry Facility, BMSF at the Mark Wainwright Analytical Centre), which are based on UNSW Kensington campus. They help out greatly with all our sequencing and mass spectrometry needs. We also have a strong affiliation and collaboration with the Children's Cancer Institute of Australia (CCIA), the Drug Discovery Centre, to test and develop our new small molecule therapies.

Avatar acceptability survey

We're doing a survey about emerging technologies that use a person's cells to predict how they will respond to certain medications. Like to join in?

When it comes to medication, everyone responds to drugs differently. New technologies in medicine are making it possible to develop truly personalised care for people with serious, chronic and life-limiting disease.

This short video is part of a research survey with UNSW that asks people about their perspectives on the new technologies that may be available in the near future.

If you wish to participate in this survey, please watch the video describing the new "avatar" technology and fill out the following questionnaire, which will take about 10 minutes to complete. These technologies are not available to the public but are available as a research pipeline in some laboratories.

Clinical Services

For more information on Cystic fibrosis services at Sydney Children's Hospital, please visit the Sydney Children's Hospitals Network.

Study with us

We are currently recruiting PhD, Masters, and Honours students.
Please contact Dr Shafagh Waters for further information about current projects.

Further information on enrolment and scholarships can be found on the UNSW Sydney Graduate Research School website.

Acknowledgements

Our cystic fibrosis-related studies are supported by Sydney Children’s Hospitals Foundation.

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