Associate Professor (Keith) Chee Ooi

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Discipline:

Paediatrics

A/Professor (Keith) Chee Y. Ooi (MBBS, DipPaed, PhD, FRACP) is a Clinical Academic at the Discipline of Paediatrics, School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales (UNSW), Sydney, Australia. He is an Associate Professor of Medicine, UNSW and Specialist Paediatric Gastroenterologist at Sydney Children’s Hospital Randwick, Australia. Clinically, he sees children with all aspects of gastrointestinal, pancreatic and nutritional conditions.

Past:

Dr Ooi graduated from the University of Melbourne in 2000, with the Clara Myers Prize in Paediatrics. He commenced training in paediatric gastroenterology at Sydney Children’s Hospital Randwick, supported by the Sydney Children’s Hospital Foundation Subspecialty Fellowship Award (2006, 2007). He accepted the offer of a 3-year clinical research fellowship (2007-2010) at the prestigious Hospital for Sick Children and University of Toronto, Toronto, Canada, to pursue a research path, undertake a PhD and broaden his clinical experience. He was supervised and mentored by late Dr Peter Durie (http://www.sickkids.ca/Gastroenterology/Who-We-Are/Our-History/in-memory-dr-peter-durie.html), a giant in the field of paediatric gastroenterology, CF and pancreatology. This was supported by the Sydney Children’s Hospital Travelling Fellowship Award (2007), Canadian Cystic Fibrosis Foundation Fellowship Award (2008-2010) and Career Enhancement Award, Canadian Child Health Clinician Scientist Program (2009-2010). He was awarded both the Dick Hamilton and Clinical Research awards in 2010 by the Hospital for Sick Children and University of Toronto respectively, for his research excellence. He returned to Sydney in mid-2010 as a clinical academic in pursuit of research and academia, while having opportunities for clinical interface within a tertiary hospital setting. He completed his PhD on genotype-phenotype correlations in CF at UNSW in 2014 and was awarded the Dean's Rising Star award (UNSW Medicine) in 2015.

Present and Future:

Dr Ooi is a translational clinician scientist aimed at improving patient health outcomes. He is recognised internationally as an expert in gastrointestinal (GI) and nutritional issues in cystic fibrosis (CF).

He established and leads a research program that has been continually funded since 2015 (PhD conferred in 2014). Despite his clinical duties, he has led a successful program on CF Gastroenterology focused on GI inflammation, microbiome & pancreatic diseases related to CF and individuals who carry CF mutation(s). He built his research team from scratch to now include post-doctorals, research assistant, higher degree research (PhD and Masters) students and undergraduate research students.

He initiated/leads/collaborates with a local and international network of clinicians, allied healths and scientists. He has established industry partnerships for translational goals. He is the lead Chief Investigator a probiotic trial for children with CF (funded by the CF Foundation, USA). He is the only Australian (and only non-North American and non-European) Chief (Principle) Investigator of INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE), which is the largest and most successful paediatric recurrent/chronic pancreatitis consortium globally (funded by the NIH, USA).

He has published widely (>100) in peer-reviewed journal articles and textbook chapters including as either first or last author in the highest ranked journals in the fields of gastroenterology (Ooi et al. Gastroenterology 2010; Ooi et al. Gastroenterology 2011), CF/pulmonology (Ooi et al. Thorax 2012; Ooi et al. Thorax 2014) and paediatrics (Ooi et al. Pediatrics 2015; Kumar, Ooi et al. JAMA Peds 2016).

He is regularly invited to speak at prestigious international and national conferences. He has won numerous awards and receives research funding nationally and internationally.

His research expertise and leadership have been widely sought after, and has been leveraged into broader fields:

GI inflammation & microbiome program related to: (1) colon cancer in adults with CF; (2) impact of serious medical illness in infancy on childhood mental health; and (3) autism spectrum disorder.
Pancreatic diseases program, including international studies in acute pancreatitis and as the only paediatric founding member of the Australia-New Zealand Alliance for Pancreas Research.

School:

Discipline of Paediatrics

Phone:

(02) 9382 5500

Email:

keith.ooi@unsw.edu.au

University role:

Consultant in Paediatric Gastroenterology

Qualifications:

MBBS, DipPaed, PhD, FRACP

Grants:

Dr Ooi has secured a total research income >AUD $8 million.

Recent major funding successes as Chief Investigator (CI) include (1) >$1M for probiotic and microbiome research in CF (as lead CI: Cystic Fibrosis Foundation, USA; 2018); (2) >$2M in philantropic donations in CF (2016, 2017); (3) ~$3M for childhood recurrent/chronic pancreatitis (National Institutes of Health, USA; 2015).

Competitive – Chief Investigator

2019 SWSLHD Clinical Knowledge Exchange Seed Funding Application

Investigating the role of chronic stress in children with autism

$40,000 (18 months)

Chief Investigator – D

(CIA – Adam Walker and Valsamma Eapen)

2019 UNSW Medicine Neuroscience, Mental Health and Addiction Theme and SPHERE Clinical Academic Group

Collaborative Research Seed Funding

$40,000 (1 year)

Identifying Behavioural and Biological Profiles to inform targeted intervention in Autism Spectrum Disorder

Chief Investigator – D

(Eapen V, Walker A, Zieba J, Ooi CY, Masi A, Kasparian N, Morris M)

2019 Australian Cystic Fibrosis Research Trust

$50,000 (1 year)

The use of non-invasive biomarkers as a screening tool and the role of gut inflammation and microbes in adult cystic fibrosis colorectal cancer.

Chief Investigator – A

2018 Evaluating the Gut-Brain Axis in Autism

UNSW Medicine Neuroscience, Mental Health and Addictions Theme and SPHERE

$19,926 (12 months)

Chief Investigator – C

(Margaret M, Eapen V, Ooi CY, Kasparian N, Kendig M)

2018 Research computer for bioinformatics and complex statistical analysis

Equipment Grant

School of Women’s and Children’s Health, Medicine, UNSW

$8,723.92 (12 months)

Chief Investigator - A

2018 Supporting Children with Complex Feeding Difficulties (SuCCEED)

Study.

SPHERE “Maridulu Budyari Gumal” (Sydney Partnership for Health, Education, Research and Enterprise) - Early Life Determinants of Health (ELDoH) Stream

$20,000 (12 months)

Chief Investigator

(CIA – Chris Elliott)

2018 The PEARL-CF Study

Clinical Research Award

Cystic Fibrosis Foundation

USD $999,183 (3 years) = AUD $1,295,041

Chief Investigator - A

2017 RNA therapeutics : novel paradigm in mutation independent CF therapy

Cystic Fibrosis Australia Innovation Grant

$70,000 (2 years)

Chief Investigator – D

(Waters S, Jaffe A, Morris K, Ooi CY, Patel H)

2017 The Heart-Gut-Brain Axis: Investigating the impact of serious medical illness in infancy on child and adolescent mental health, gut microbiota, and stress hormone levels.

UNSW Neuroscience, Mental Health and Addictions and SPHERE Mindgardens. $40,000 (1 year).

Chief Investigator – E

(Kasparian N, Kan J, Callaghan B, Sholler G, Ooi CY, Winlaw D, Coffey M.)

2016-2017 University of New South Wales

Pro-Vice Chancellor (Education)

PlayMed

$180,000

Chief Investigator - A

2016-2017 Thrasher Research Fund - Early Career Award Program

USD $25,000 = AUD $32,402

Probiotics in infants with cystic fibrosis: Effects of early intervention

Chief Investigator - A

2015-2020 U01 Grant (U01 DK108334-01)

National Institute of Health, USA

USD $2,235,241 = AUD $2,897,000

International Study Group of Pediatric Pancreatitis: In search for a cure

(INSPIRRE) to Study Pediatric Chronic Pancreatitis

Principal Investigator

(CIA – Aliye Uc)

2015-2016 University of New South Wales Learning and Teaching Innovation Grant

$20,000

A Novel Computer-based Approach to Educating Medical Students through an Online Experiential Role-playing Game

Chief Investigator - A

2015-2016 Sydney Children’s Hospital Foundation Seed Funding

$20,000

Early Feeding in Acute Pancreatitis in Children – A Randomised Controlled Trial

Chief Investigator - A

2012 Cystic Fibrosis Australia Research Trust

AUD $75,049

Project Title: The “gut-lung axis”: defining & understanding the gut microbiota in cystic fibrosis

Chief Investigator – A

2012 Servier Staff Research Fellowship, Royal Australasian College of Physicians Research and Education Foundation Award

AUD $10,000

Project Title: Molecular characterization and understanding the effects of altered gut microbiota in cystic fibrosis

Chief Investigator – A

Philantropic – Chief Investigator

2018-2019 University of New South Wales Foundation (Evolution Health Pty Ltd)

PEARL-CF study

$126,380.98

Chief Investigator - A

2017 University of New South Wales Foundation (Bank Of Queensland)

The early life effects of probiotics on the gut in CF (PEARL-CF “Plus”)

$30,690.05

Chief Investigator - A

2016 University of New South Wales Foundation (Evolution Health Pty Ltd)

PEARL-CF study

$60,000

Chief Investigator - A

2016 Sydney Children’s Hospital Foundation

Establishing Ex Vivo models for accelerating drug discovery and treatment in cystic fibrosis (CF): Development of the Cystic Fibrosis Avatar

$2,320,000

Chief Investigator

Competitive – Associate Investigator/Co-Investigator/Collaborator

2019 Australian Cystic Fibrosis Research Trust

David Millar Giles Innovation Grant

“An Australian Alliance of personalised lab grown mini-organs to save the rarest of them all”

$45,000 (12 months; CI – Shafagh Waters)

Associate Investigator

2018 Breakthrough Research Grant

UNSW Business School

Good Decisions in Education: The Smart Tech & Education Project (STEP)

$80,000 (12 months)

Associate Investigator

2017 Supporting Children with Complex Feeding Difficulties (SuCCEED)

Study.

SPHERE “Maridulu Budyari Gumal” (Sydney Partnership for Health, Education, Research and Enterprise) - Early Life Determinants of Health (ELDoH) Stream

$50,000 (12 months)

Co-Investigator (Collaborator)

2014-2015 R21 Grant (DK096327-02S1)

National Institute of Health, USA

USD $107,662 = AUD $140,000

International Study Group of Pediatric Pancreatitis: In search for a cure

(INSPIRRE)

Co-Investigator (Collaborator)

2012-2015 R21 Grant (DK096327)

National Institute of Health, USA

USD $275,000 = AUD $360,000

International Study Group of Pediatric Pancreatitis: In search for a cure

(INSPIRRE)

Co-Investigator (Collaborator)

2012 University of New South Wales/Goldstar-NHMRC – APP1027693

Project Title: Investigation of the role of the intestinal microflora in the aetiology of Crohn's Disease

AUD $40,000

Associate Investigator – H

Awards:

He has received:

3 research awards, including the UNSW Medicine Dean’s Rising Star Award in 2015.
1 Best Oral Presentation award (Australasian CF Conference 2019)
4 Poster awards

Keywords:

microbiome

gut microbiome

cystic fibrosis

inflammation

diet

diet quality

gastroenterology & hepatology

gastrointestinal diseases

pancreas

exocrine pancreatic insufficiency

probiotics

clinical trials

Research

Research activities:

Research Areas:

Cystic fibrosis (CF)
Gut microbiome and inflammation
- In CF, autism spectrum disorder and other chronic diseases
- Evaluation of taxonomic and functional alterations of the gut microbiome to identify pathogenic mechanisms, correlations with clinical phenotype, and uncover novel therapeutic interventions.
- Role of diet - "Let your food be your medicine and your medicine be your food." (Hippocrates)
- Impact on mental health and quality of life (via the "gut-brain" axis)
Pancreatic diseases
Pancreatitis

Summary Metrics: (updated Jan 1, 2020)

He has 97 peer-reviewed journal articles (including letters and editorials) with 58 (60%) as first and/or senior author. 69 of them (71%) were published since 2015 (PhD conferred in 2014) i.e. upward publications trajectory of ~240%.
- h-index of 27 (Google Scholar) and 21 (WOS and Scopus)
- Click on the links to different publications in the top right "Publications" box of this page
- https://scholar.google.com.au/citations?user=KzsBuD0AAAAJ&hl=en
46 invites as symposium speaker (26 at international conferences).
42 oral abstract presentations at international conferences (including those as senior investigator and presented by his student/trainee)

Examples of Research Achievements:

CF gastroenterology

Dr Ooi has clinical-research expertise and interests in gastrointestinal issues in CF including gut inflammation, changes in the gut microbiome, pancreatitis, pancreatic insufficiency and the emerging issue of increased risk of gastrointestinal cancers.
OOI et al. Gastroenterology 2011;140(1):153–161 (https://www.ncbi.nlm.nih.gov/pubmed/20923678). This is the first study to unravel the complex relationship between severity of cystic fibrosis transmembrane conductance regulator (CFTR) mutations and risk of pancreatitis. Developed & validated a novel surrogate measure of CF mutation and genotype severity, known as the “Pancreatic Insufficiency Prevalence (PIP)” score, with wide clinical & research application. This score has been used clinically to predict pancreatitis risk and for patient education. This score has been used in research to classify cystic fibrosis (CF) patients by CFTR genotype. Methodology to derive score also directly adapted to study other CF phenotypes.
His recent works has extended into understanding the disease processes affecting the gastrointestinal tract in CF, using faecal biomarkers (Pang et al. J Gastroenterol Hepatol 2015, Dhaliwal et al. J Pediatr Gastroenterol Nutr 2015, Ooi et al. Dig Dis Sci 2015, Garg et al. J Cyst Fibros 2017, Garg et al. J Cyst Fibros 2018).
Nielsen,…OOI (SENIOR AUTHOR). Sci Rep 2016;6:24857 (https://www.ncbi.nlm.nih.gov/pubmed/27143104). Identified potential window of therapeutic opportunity in early childhood for CF gut dysbiosis, and provided justification for a probiotic trial in very young children with CF (AUD1.3M by the CF Foundation, USA) & industry engagement (national & international) for probiotic research.
Kumar, OOI et al (CO-FIRST AUTHORS). JAMA Pediatr 2016;170(6):562-9 (https://www.ncbi.nlm.nih.gov/pubmed/27064572). NIH funded. Showed childhood recurrent/chronic pancreatitis has different causative factors compared to adults, with genetic causes most frequent. The most frequent mutation identified were CFTR mutations. Findings incorporated/cited by 3 international guidelines. Genetic tests now recommended as part of routine workup for children with recurrent/chronic pancreatitis.

CF diagnostic issues and non-classic manifestations

Dr Ooi is passionate about diagnostic issues related to children and adults with single-organ manifestations of CF (Ooi et al. Thorax 2012, Ooi et al. Thorax 2014) and newborn screen positive infants with an indeterminate diagnosis of CF (Ooi et al. Pediatrics 2015). He has experience in electrophysiological diagnostic tests, including the nasal potential difference test and intestinal ion channel measurement. He developed a novel diagnostic test for CF known as the “combined ion channel measurement” (Ooi et al. Ann Am Thorac Soc 2014).
OOI et al. Thorax 2012;67(7):618-24 (https://www.ncbi.nlm.nih.gov/pubmed/22504961). Found the same CF patients who undergo same diagnostic tests can have different diagnostic outcomes geographically due to different guidelines. Led experts to revise into a single, global CF diagnostic guideline. Received an editorial & voted one of best 2012 articles by Thorax editor.
OOI et al. Pediatrics 2015;135(6):e1377-85 (https://www.ncbi.nlm.nih.gov/pubmed/25963003). Findings showed decades-old clinical practice of discharging infants with inconclusive CF diagnosis to be inappropriate. 10% of these infants developed CF and risked missing out early therapies. Informed new international management guidelines.

Pancreatitis and pancreatic diseases

Dr Ooi is an international expert in childhood pancreatitis. He has developed clinical tools for predicting severe (https://www.ncbi.nlm.nih.gov/pubmed/23403441) and biliary causes (https://www.ncbi.nlm.nih.gov/pubmed/24013807) of acute pancreatitis in children. He is Chief Investigator of an international randomised controlled trial in paediatric acute pancreatitis. Dr Ooi is a founding member of ANZ Alliance for Pancreatic Research.

Socio-economic Objective (SEO) tags:

Child Health

Nutrition

Field of Research (FOR) Tag:

Paediatrics

Gastroenterology and Hepatology

Medical and Health Sciences

Nutrition and Dietetics

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

Dr Ooi has an impressive track record of outputs and success in research supervision.

As of Jan 1, 2020:

He has 3 PhD & 1 Masters students (3 as primary supervisor; 1 submitted). Their achievements include: (i) 15 oral abstracts (10 international); (ii) 6 research awards (2 international - Early Career Investigator Award, USA 2019; Best Oral Presentation 2018); (iii) 11 journal articles; and (v) 2 textbook chapters.

He has supervised 23 research medical students, including 1 Honours (primary supervisor), 21 undergraduate students (13 primary; 8 co-supervisor), 1 international research student (Uni Groningen, Netherlands, 2015) & 11 physician trainees. My effectiveness as their research supervisor is evidenced by 28 original research articles (cited 283; FWCI up to 6.68), 6 reviews (cited 132), 7 textbook chapters, 14 international oral abstracts, 5 national oral abstracts, & 5 research awards (international & national). 4, 1 and 2 original research articles impacted on & cited by European (Parniczky 2018), US (Abu-El-Haija 2018) & Australasian (Smith 2016) clinical guidelines respectively.

Currently supervising:

Dr Ooi supervises medical students (e.g. Independent Learning Projects and Honours) and higher degree research (PhD or Masters) students in his areas of research (refer above and to keywords).

Supervision keywords:

pancreatic diseases

cystic fibrosis

paediatric

children

gastrointestinal diseases

gastroenterology

gut microbiome

microbiome

inflammation

diet

diet quality

probiotics

autism

autism spectrum disorder

child mental health

quality of life (qol)

Teaching:

Dr Ooi is an innovator in medical education and serious game developer. He is interested in improving the quality of teaching through novel innovative approaches to medical education.

He received the Learning and Teaching Innovation Grant in 2015 to develop PlayMed. PlayMed is a novel educational game to teach medicine through immersive, experience-based learning. His achievements with PlayMed has been featured in media such as The Australian “Gaming injects medical practice into studies” (https://twitter.com/keithcyooi/status/902790787448147968 or https://www.theaustralian.com.au/higher-education/medical-students-and-playmed-gaming-unite-for-learning/news-story/b0536719bc52882071baeb86ea913dc9) and The Australian Hospital Healthcare Bulletin “In Conversation….. with Dr Keith Ooi” (https://www.hospitalhealth.com.au/content/facility-admin/article/in-conversation-with-dr-keith-ooi-1073474795). He is conducting a randomised controlled trial in serious games using PlayMed.

He is also the co-creator of VirtualDoc, which is the world's first virtual reality game to teach paediatric resuscitation.

He was the Convenor for Paediatrics (Phase 3 of the undergraduate medical program) for the Faculty of Medicine, UNSW between 2010-2013.

Media

Facebook:

https://www.facebook.com/UNSWPaediatrics

Twitter Account:

https://twitter.com/KeithCYOoi

Publications related to this Person

Book Chapters

Journal articles

Abu-El-Haija M; Lowe M; Barth B; Bellin MD; Fishman DS; Freedman S; Gariepy C; Giefer MJ; Gonska T; Heyman MB; Himes R; Husain S; Lin TK; Liu Q; Mascarenhas MR; Maqbool A; McFerron B; Morinville V; Nathan J; Ooi CY; Perito E; Pohl JF; Schwarzenberg SJ; Shah U; Troendle D; Werlin S; Wilschanski M; Zimmerman B; Uc A, 2020, 'Pediatric chronic pancreatitis without prior acute or acute recurrent pancreatitis: A report from the INSPPIRE consortium', Pancreatology, vol. 20, pp. 781 - 784, http://dx.doi.org/10.1016/j.pan.2020.04.001

Coffey MJ; Mckay IR; Doumit M; Chuang S; Adams S; Stelzer-Braid S; Waters SA; Kasparian NA; Thomas T; Jaffe A; Katz T; Ooi CY, 2020, 'Evaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in children with chronic disease at an Australian tertiary paediatric hospital', BMJ Open, vol. 10, pp. e033916, http://dx.doi.org/10.1136/bmjopen-2019-033916

Prentice BJ; Chelliah A; Ooi CY; Hameed S; Verge CF; Plush L; Widger J, 2020, 'Peak OGTT glucose is associated with lower lung function in young children with cystic fibrosis', Journal of Cystic Fibrosis, vol. 19, pp. 305 - 309, http://dx.doi.org/10.1016/j.jcf.2019.05.005

Coffey MJ; Garg M; Homaira N; Jaffe A; Ooi CY, 2020, 'Probiotics for people with cystic fibrosis', Cochrane Database of Systematic Reviews, vol. 2020, http://dx.doi.org/10.1002/14651858.CD012949.pub2

Tham A; Katz TE; Sutherland RE; Garg M; Liu V; Tong CW; Brunner R; Quintano J; Collins C; Ooi CY, 2020, 'Micronutrient intake in children with cystic fibrosis in Sydney, Australia', Journal of Cystic Fibrosis, vol. 19, pp. 146 - 152, http://dx.doi.org/10.1016/j.jcf.2019.08.028

Perito ER; Palermo TM; Pohl JF; Mascarenhas M; Abu-El-Haija M; Barth B; Bellin MD; Fishman DS; Freedman S; Gariepy C; Giefer M; Gonska T; Heyman MB; Himes RW; Husain SZ; Lin T; Liu Q; Maqbool A; McFerron B; Morinville VD; Nathan JD; Ooi CY; Rhee S; Schwarzenberg SJ; Shah U; Troendle DM; Werlin S; Wilschanski M; Zheng Y; Zimmerman MB; Lowe M; Uc A, 2020, 'Factors Associated with Frequent Opioid Use in Children with Acute Recurrent and Chronic Pancreatitis', Journal of Pediatric Gastroenterology and Nutrition, vol. 70, pp. 106 - 114, http://dx.doi.org/10.1097/MPG.0000000000002502

van der Haak N; King SJ; Crowder T; Kench A; Painter C; Saxby N, 2020, 'Highlights from the nutrition guidelines for cystic fibrosis in Australia and New Zealand', Journal of Cystic Fibrosis, vol. 19, pp. 16 - 25, http://dx.doi.org/10.1016/j.jcf.2019.05.007

Palermo TM; Murray C; Aalfs H; Abu-El-Haija M; Barth B; Bellin MD; Ellery K; Fishman DS; Gariepy CE; Giefer MJ; Goday P; Gonska T; Heyman MB; Husain SZ; Lin TK; Liu QY; Mascarenhas MR; Maqbool A; McFerron B; Morinville VD; Nathan JD; Ooi CY; Perito ER; Pohl JF; Schwarzenberg SJ; Sellers ZM; Serrano J; Shah U; Troendle D; Zheng Y; Yuan Y; Lowe M; Uc A, 2020, 'Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC)', Contemporary Clinical Trials, vol. 88, http://dx.doi.org/10.1016/j.cct.2019.105898

Gunasagaran HL; Varjavandi V; Lemberg DA; Ooi CY; Gupta N; Krishnan U, 2020, 'The utility of multichannel intraluminal impedance-pH testing in tailoring the management of paediatric gastro-oesophageal reflux disease', Acta Paediatrica, International Journal of Paediatrics, http://dx.doi.org/10.1111/apa.15317

Coffey MJ; Garg M; Homaira N; Jaffe A; Ooi CY, 2020, 'A systematic cochrane review of probiotics for people with cystic fibrosis', Paediatric Respiratory Reviews, http://dx.doi.org/10.1016/j.prrv.2020.06.020

Coffey MJ; Low I; Stelzer-Braid S; Wemheuer B; Garg M; Thomas T; Jaffe A; Rawlinson WD; Ooi CY, 2020, 'The intestinal virome in children with cystic fibrosis differs from healthy controls.', PLoS One, vol. 15, pp. e0233557, http://dx.doi.org/10.1371/journal.pone.0233557

Singh H; Coffey MJ; Ooi CY, 2020, 'Cystic Fibrosis-related Liver Disease is Associated With Increased Disease Burden and Endocrine Comorbidities.', J Pediatr Gastroenterol Nutr, vol. 70, pp. 796 - 800, http://dx.doi.org/10.1097/MPG.0000000000002694

Coffey MJ; Nielsen S; Wemheuer B; Kaakoush NO; Garg M; Needham B; Pickford R; Jaffe A; Thomas T; Ooi CY, 2019, 'Gut Microbiota in Children With Cystic Fibrosis: A Taxonomic and Functional Dysbiosis', Scientific Reports, vol. 9, pp. 18593, http://dx.doi.org/10.1038/s41598-019-55028-7

Prentice BJ; Ooi CY; Strachan RE; Hameed S; Ebrahimkhani S; Waters SA; Verge CF; Widger J, 2019, 'Early glucose abnormalities are associated with pulmonary inflammation in young children with cystic fibrosis', Journal of Cystic Fibrosis, vol. 18, pp. 869 - 873, http://dx.doi.org/10.1016/j.jcf.2019.03.010

Tan SMJ; Coffey MJ; Ooi CY, 2019, 'Differences in clinical outcomes of paediatric cystic fibrosis patients with and without meconium ileus', Journal of Cystic Fibrosis, vol. 18, pp. 857 - 862, http://dx.doi.org/10.1016/j.jcf.2019.09.008

Ooi CY; Sutherland R; Castellani C; Keenan K; Boland M; Reisman J; Bjornson C; Chilvers MA; Van Wylick R; Kent S; Price A; Mateos-Corral D; Hughes D; Solomon M; Zuberbuhler P; Brusky J; Durie PR; Ratjen F; Gonska T, 2019, 'Immunoreactive trypsinogen levels in newborn screened infants with an inconclusive diagnosis of cystic fibrosis', BMC Pediatrics, vol. 19, pp. 369, http://dx.doi.org/10.1186/s12887-019-1756-4

Liu QY; Abu-El-Haija M; Husain SZ; Barth B; Bellin M; Fishman DS; Freedman SD; Gariepy CE; Giefer MJ; Gonska T; Heyman MB; Himes R; Lin TK; Maqbool A; Mascarenhas M; McFerron BA; Morinville VD; Nathan JD; Ooi CY; Perito ER; Pohl JF; Rhee S; Schwarzenberg SJ; Shah U; Troendle D; Werlin SL; Wilschanski M; Zimmerman MB; Lowe ME; Uc A, 2019, 'Risk Factors for Rapid Progression From Acute Recurrent to Chronic Pancreatitis in Children: Report From INSPPIRE', Journal of pediatric gastroenterology and nutrition, vol. 69, pp. 206 - 211, http://dx.doi.org/10.1097/MPG.0000000000002405

Lin TK; Abu-El-Haija M; Nathan JD; Palermo JP; Barth B; Bellin M; Fishman DS; Freedman SD; Gariepy CE; Giefer MJ; Gonska T; Heyman MB; Himes R; Husain SZ; Liu Q; Maqbool A; Mascarenhas M; McFerron B; Morinville VD; Ooi CY; Perito E; Pohl JF; Rhee S; Schwarzenberg SJ; Shah U; Troendle D; Werlin SL; Wilschanski M; Zimmerman MB; Lowe ME; Uc A, 2019, 'Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report from INSPPIRE', Journal of Clinical Gastroenterology, vol. 53, pp. E232 - E238, http://dx.doi.org/10.1097/MCG.0000000000001063

Lopez RN; Al Rawahi Y; Stormon M; Chennapragada M; Ooi CY, 2019, 'Hepatobiliary and Pancreatic: Hepatic arterioportal fistula: A novel and treatable feature of Alagille syndrome', Journal of Gastroenterology and Hepatology (Australia), vol. 34, pp. 633, http://dx.doi.org/10.1111/jgh.14506

Schwarzenberg SJ; Uc A; Zimmerman B; Wilschanski M; Wilcox CM; Whitcomb DC; Werlin SL; Troendle D; Tang G; Slivka A; Singh VK; Sherman S; Shah U; Sandhu BS; Romagnuolo J; Rhee S; Pohl JF; Perito ER; Ooi CY; Nathan JD; Muniraj T; Morinville VD; McFerron B; Mascarenhas M; Maqbool A; Liu Q; Lin TK; Lewis M; Husain SZ; Himes R; Heyman MB; Guda N; Gonska T; Giefer MJ; Gelrud A; Gariepy CE; Gardner TB; Freedman SD; Forsmark CE; Fishman DS; Cote GA; Conwell D; Brand RE; Bellin M; Barth B; Banks PA; Anderson MA; Amann ST; Alkaade S; Abu-El-Haija M; Abberbock JN; Lowe ME; Yadav D, 2019, 'Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors', Journal of pediatric gastroenterology and nutrition, vol. 68, pp. 566 - 573, http://dx.doi.org/10.1097/MPG.0000000000002279

Fawcett LK; Widger J; Henry GM; Ooi CY, 2019, 'Case report: Cholecystoduodenostomy for cholestatic liver disease in a premature infant with cystic fibrosis and short gut syndrome', BMC Pediatrics, vol. 19, http://dx.doi.org/10.1186/s12887-019-1443-5

Kan JM; Cowan CSM; Ooi CY; Kasparian NA, 2019, 'What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review', Developmental Psychobiology, http://dx.doi.org/10.1002/dev.21819

Bellin MD; Lowe M; Zimmerman MB; Wilschanski M; Werlin S; Troendle DM; Shah U; Schwarzenberg SJ; Pohl JF; Perito E; Ooi CY; Nathan JD; Morinville VD; McFerron BA; Mascarenhas MR; Maqbool A; Liu Q; Lin TK; Husain SZ; Himes R; Heyman MB; Gonska T; Giefer MJ; Gariepy CE; Freedman SD; Fishman DS; Barth B; Abu-El-Haija M; Uc A, 2019, 'Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data from the INSPPIRE Cohort', Journal of Pediatric Gastroenterology and Nutrition, http://dx.doi.org/10.1097/MPG.0000000000002482

Bellin MD; Lowe M; Zimmerman MB; Wilschanski M; Werlin S; Troendle DM; Shah U; Schwarzenberg SJ; Pohl JF; Perito E; Ooi CY; Nathan JD; Morinville VD; McFerron BA; Mascarenhas MR; Maqbool A; Liu Q; Lin TK; Husain SZ; Himes R; Heyman MB; Gonska T; Giefer MJ; Gariepy CE; Freedman SD; Fishman DS; Barth B; Abu-El-Haija M; Uc A, 2019, 'Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort.', J Pediatr Gastroenterol Nutr, vol. 69, pp. 599 - 606, http://dx.doi.org/10.1097/MPG.0000000000002482

Ooi CY; Syed SA; Rossi L; Garg M; Needham B; Avolio J; Young K; Surette MG; Gonska T, 2018, 'Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation', Scientific Reports, vol. 8, pp. 17834, http://dx.doi.org/10.1038/s41598-018-36364-6

Uc A; Perito ER; Pohl JF; Shah U; Abu-El-Haija M; Barth B; Bellin MD; Ellery KM; Fishman DS; Gariepy CE; Giefer MJ; Gonska T; Heyman MB; Himes RW; Husain SZ; Maqbool A; Mascarenhas MR; McFerron BA; Morinville VD; Lin TK; Liu QY; Nathan JD; Rhee SJ; Ooi CY; Sellers ZM; Schwarzenberg SJ; Serrano J; Troendle DM; Werlin SL; Wilschanski M; Zheng Y; Yuan Y; Lowe ME, 2018, 'International study group of pediatric pancreatitis: In search for a Cu RE cohort study: Design and rationale for INSPPIRE 2 from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer', Pancreas, vol. 47, pp. 1222 - 1228, http://dx.doi.org/10.1097/MPA.0000000000001172

Uc A; Zimmerman MB; Wilschanski M; Werlin SL; Troendle D; Shah U; Schwarzenberg SJ; Rhee S; Pohl JF; Perito ER; Palermo JJ; Ooi CY; Liu Q; Lin TK; Morinville VD; McFerron BA; Husain SZ; Himes R; Heyman MB; Gonska T; Giefer MJ; Gariepy CE; Freedman SD; Fishman DS; Bellin MD; Barth B; Abu-El-Haija M; Lowe ME, 2018, 'Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis', Pancreas, vol. 47, pp. 967 - 973, http://dx.doi.org/10.1097/MPA.0000000000001120

Bolia R; Ooi CY; Lewindon P; Bishop J; Ranganathan S; Harrison J; Ford K; van der Haak N; Oliver MR, 2018, 'Practical approach to the gastrointestinal manifestations of cystic fibrosis', Journal of Paediatrics and Child Health, vol. 54, pp. 609 - 619, http://dx.doi.org/10.1111/jpc.13921

Garg M; Swab M; Gibney D; Cohen J; Gupta N; Ooi CY, 2018, 'Influence of Dietitians in Preventing Parenteral Nutrition Prescription Errors in Children', Journal of Parenteral and Enteral Nutrition, vol. 42, pp. 607 - 612, http://dx.doi.org/10.1177/0148607117697935

Coffey MJ; Garg M; Homaira N; Jaffe A; Ooi CY, 2018, 'Probiotics for people with cystic fibrosis', Cochrane Database of Systematic Reviews, vol. 2018, http://dx.doi.org/10.1002/14651858.CD012949

Garg M; Leach ST; Pang T; Needham B; Coffey MJ; Katz T; Strachan R; Widger J; Field P; Belessis Y; Chuang S; Day AS; Jaffe A; Ooi CY, 2018, 'Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10 years old', Journal of Cystic Fibrosis, vol. 17, pp. 109 - 113, http://dx.doi.org/10.1016/j.jcf.2017.07.011

Garg M; Leach ST; Day AS; Ooi CY, 2018, 'Fecal calprotectin concentrations in young children with cystic fibrosis: Authors response', Journal of Cystic Fibrosis, vol. 17, pp. e10 - e11, http://dx.doi.org/10.1016/j.jcf.2017.10.012

Sue A; Dehlsen K; Ooi CY, 2018, 'Paediatric Patients with Coeliac Disease on a Gluten-Free Diet: Nutritional Adequacy and Macro- and Micronutrient Imbalances', Current Gastroenterology Reports, vol. 20, http://dx.doi.org/10.1007/s11894-018-0606-0

Scheers I; Palermo JJ; Freedman S; Wilschanski M; Shah U; Abu-El-Haija M; Barth B; Fishman DS; Gariepy C; Giefer MJ; Heyman MB; Himes RW; Husain SZ; Lin TK; Liu Q; Lowe M; Mascarenhas M; Morinville V; Ooi CY; Perito ER; Piccoli DA; Pohl JF; Schwarzenberg SJ; Troendle D; Werlin S; Zimmerman B; Uc A; Gonska T, 2018, 'Recommendations for diagnosis and management of autoimmune pancreatitis in childhood: Consensus from INSPPIRE', Journal of Pediatric Gastroenterology and Nutrition, vol. 67, pp. 232 - 236, http://dx.doi.org/10.1097/MPG.0000000000002028

Freeman AJ; Ooi CY, 2017, 'Pancreatitis and pancreatic cystosis in Cystic Fibrosis', Journal of Cystic Fibrosis, vol. 16, pp. S79 - S86, http://dx.doi.org/10.1016/j.jcf.2017.07.004

Scheers I; Palermo JJ; Freedman S; Wilschanski M; Shah U; Abu-El-Haija M; Barth B; Fishman DS; Gariepy C; Giefer MJ; Heyman MB; Himes RW; Husain SZ; Lin TK; Liu Q; Lowe M; Mascarenhas M; Morinville V; Ooi CY; Perito ER; Piccoli DA; Pohl JF; Schwarzenberg SJ; Troendle D; Werlin S; Zimmerman B; Uc A; Gonska T, 2017, 'Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management', American Journal of Gastroenterology, vol. 112, pp. 1604 - 1611, http://dx.doi.org/10.1038/ajg.2017.85

Garg M; Leach ST; Coffey MJ; Katz T; Strachan R; Pang T; Needham B; Lui K; Ali F; Day AS; Appleton L; Moeeni V; Jaffe A; Ooi CY, 2017, 'Age-dependent variation of fecal calprotectin in cystic fibrosis and healthy children', Journal of Cystic Fibrosis, vol. 16, pp. 631 - 636, http://dx.doi.org/10.1016/j.jcf.2017.03.010

Nikfarjam M; Wilson JS; Smith RC; Australasian Pancreatic Club Pancreatic Enzyme Replacement Therapy Guidelines Working Group , 2017, 'Diagnosis and management of pancreatic exocrine insufficiency.', Med J Aust, vol. 207, pp. 161 - 165, http://dx.doi.org/10.5694/mja16.00851

Giefer MJ; Lowe ME; Werlin SL; Zimmerman B; Wilschanski M; Troendle D; Schwarzenberg SJ; Pohl JF; Palermo J; Ooi CY; Morinville VD; Lin TK; Husain SZ; Himes R; Heyman MB; Gonska T; Gariepy CE; Freedman SD; Fishman DS; Bellin MD; Barth B; Abu-El-Haija M; Uc A, 2017, 'Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations', Journal of Pediatrics, vol. 186, pp. 95 - 100, http://dx.doi.org/10.1016/j.jpeds.2017.03.063

Coffey MJ; Whitaker V; Gentin N; Junek R; Shalhoub C; Nightingale S; Hilton J; Wiley V; Wilcken B; Gaskin KJ; Ooi CY, 2017, 'Differences in Outcomes between Early and Late Diagnosis of Cystic Fibrosis in the Newborn Screening Era', Obstetrical and Gynecological Survey, vol. 72, pp. 328 - 330, http://dx.doi.org/10.1097/01.ogx.0000520558.46496.57

Chuang SYC; Sealy L; Selvadurai H; Dutt S; Ooi CY, 2017, 'An unusual case of haemolytic anaemia and failure to thrive in a Burmese refugee baby', Journal of Paediatrics and Child Health, vol. 53, pp. 500 - 502, http://dx.doi.org/10.1111/jpc.13520

Alhagamhmad MH; Lemberg DA; Day AS; Tan LZ; Ooi CY; Krishnan U; Gupta N; Munday JS; Leach ST, 2017, 'Advancing nutritional therapy: A novel polymeric formulation attenuates intestinal inflammation in a murine colitis model and suppresses pro-inflammatory cytokine production in ex-vivo cultured inflamed colonic biopsies', Clinical Nutrition, vol. 36, pp. 497 - 505, http://dx.doi.org/10.1016/j.clnu.2016.01.010

Lopez RN; Ooi CY; Krishnan U, 2017, 'Early and Peri-operative Prognostic Indicators in Infants Undergoing Hepatic Portoenterostomy for Biliary Atresia: a Review', Current Gastroenterology Reports, vol. 19, http://dx.doi.org/10.1007/s11894-017-0555-z

Webb NL; Jiwane A; Ooi CY; Nightinghale S; Adams SE; Krishnan U, 2017, 'Clinical significance of liver histology on outcomes in biliary atresia', Journal of Paediatrics and Child Health, vol. 53, pp. 252 - 256, http://dx.doi.org/10.1111/jpc.13371

Nightingale S; Stormon MO; O'Loughlin EV; Shun A; Thomas G; Benchimol EI; Day AS; Adams S; Shi E; Ooi CY; Kamath BM; Fecteau A; Langer JC; Roberts EA; Ling SC; Ng VL, 2017, 'Early Posthepatoportoenterostomy Predictors of Native Liver Survival in Biliary Atresia', Journal of Pediatric Gastroenterology and Nutrition, vol. 64, pp. 203 - 209, http://dx.doi.org/10.1097/MPG.0000000000001289

Garg M; Ooi CY, 2017, 'The Enigmatic Gut in Cystic Fibrosis: Linking Inflammation, Dysbiosis, and the Increased Risk of Malignancy', Current Gastroenterology Reports, vol. 19, http://dx.doi.org/10.1007/s11894-017-0546-0

Gariepy CE; Heyman MB; Lowe ME; Pohl JF; Werlin SL; Wilschanski M; Barth B; Fishman DS; Freedman SD; Giefer MJ; Gonska T; Himes R; Husain SZ; Morinville VD; Ooi CY; Schwarzenberg SJ; Troendle DM; Yen E; Uc A, 2017, 'Causal evaluation of acute recurrent and chronic pancreatitis in children: Consensus from the INSPPIRE group', Journal of Pediatric Gastroenterology and Nutrition, vol. 64, pp. 95 - 103, http://dx.doi.org/10.1097/MPG.0000000000001446

Lopez RN; Krishnan U; Ooi CY, 2017, 'Enteritis with pneumatosis intestinalis following rotavirus immunisation in an infant with short bowel syndrome', BMJ Case Reports, vol. 2017, http://dx.doi.org/10.1136/bcr-2017-219482

Troendle DM; Fishman DS; Barth BA; Giefer MJ; Lin TK; Liu QY; Abu-El-Haija M; Bellin MD; Durie PR; Freedman SD; Gariepy C; Gonska T; Heyman MB; Himes R; Husain SZ; Kumar S; Lowe ME; Morinville VD; Ooi CY; Palermo J; Pohl JF; Schwarzenberg SJ; Werlin S; Wilschanski M; Zimmerman MB; Uc A, 2017, 'Therapeutic endoscopic retrograde cholangiopancreatography in pediatric patients with acute recurrent and chronic pancreatitis', Pancreas, vol. 46, pp. 764 - 769, http://dx.doi.org/10.1097/MPA.0000000000000848

Uther P; Ooi CY, 2016, 'Paediatric clinical exposure for medical students: Are they seeing enough?', Journal of Paediatrics and Child Health, vol. 52, pp. 1086 - 1089, http://dx.doi.org/10.1111/jpc.13304

Duley JA; Henman MG; Carpenter KH; Bamshad MJ; Marshall GA; Ooi CY; Wilcken B; Pinner JR, 2016, 'Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine', Molecular Genetics and Metabolism, vol. 119, pp. 83 - 90, http://dx.doi.org/10.1016/j.ymgme.2016.06.008

Coffey MJ; Ooi CY, 2016, 'Ode to the exocrine pancreas', Journal of Cystic Fibrosis, vol. 15, pp. 557 - 558, http://dx.doi.org/10.1016/j.jcf.2016.07.005

Stonebraker JR; Ooi CY; Pace RG; Corvol H; Knowles MR; Durie PR; Ling SC, 2016, 'Features of Severe Liver Disease With Portal Hypertension in Patients With Cystic Fibrosis', Clinical Gastroenterology and Hepatology, vol. 14, pp. 1207 - 1215.e3, http://dx.doi.org/10.1016/j.cgh.2016.03.041

Kaakoush NO; Pickford R; Jaffe A; Ooi CY, 2016, 'Is there a role for stool metabolomics in cystic fibrosis?', Pediatrics International, vol. 58, pp. 808 - 811, http://dx.doi.org/10.1111/ped.13063

Prentice B; Hameed S; Verge CF; Ooi CY; Jaffe A; Widger J, 2016, 'Diagnosing cystic fibrosis-related diabetes: current methods and challenges', Expert Review of Respiratory Medicine, vol. 10, pp. 799 - 811, http://dx.doi.org/10.1080/17476348.2016.1190646

Williams N; Moriatis M; Chambers GM; Ooi CY, 2016, 'The role, yield and cost of paediatric faecal elastase-1 testing', Pancreatology, vol. 16, pp. 551 - 554, http://dx.doi.org/10.1016/j.pan.2016.04.001

Bierma MJ; Coffey MJ; Nightingale S; van Rheenen PF; Ooi CY, 2016, 'Predicting severe acute pancreatitis in children based on serum lipase and calcium: A multicentre retrospective cohort study', Pancreatology, vol. 16, pp. 529 - 534, http://dx.doi.org/10.1016/j.pan.2016.04.005

Kumar S; Ooi CY; Werlin S; Abu-El-Haija M; Barth B; Bellin MD; Durie PR; Fishman DS; Freedman SD; Gariepy C; Giefer MJ; Gonska T; Heyman MB; Himes R; Husain SZ; Lin TK; Lowe ME; Morinville V; Palermo JJ; Pohl JF; Schwarzenberg SJ; Troendle D; Wilschanski M; Zimmerman MB; Uc A, 2016, 'Risk factors associated with pediatric acute recurrent and chronic pancreatitis: Lessons from INSPPIRE', JAMA Pediatrics, vol. 170, pp. 562 - 569, http://dx.doi.org/10.1001/jamapediatrics.2015.4955

Nielsen S; Needham B; Leach ST; Day AS; Jaffe A; Thomas T; Ooi CY, 2016, 'Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep24857

Ooi CY; Jeyaruban C; Lau J; Katz T; Matson A; Bell SC; Adams SE; Krishnan U, 2016, 'High ambient temperature and risk of intestinal obstruction in cystic fibrosis', Journal of Paediatrics and Child Health, vol. 52, pp. 430 - 435, http://dx.doi.org/10.1111/jpc.13096

Dupuis A; Keenan K; Ooi CY; Dorfman R; Sontag MK; Naehrlich L; Castellani C; Strug LJ; Rommens JM; Gonska T, 2016, 'Prevalence of meconium ileus marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene', Genetics in Medicine, vol. 18, pp. 333 - 340, http://dx.doi.org/10.1038/gim.2015.79

Smith RC; Smith SF; Wilson J; Pearce C; Wray N; Vo R; Chen J; Ooi CY; Oliver M; Katz T; Turner R; Nikfarjam M; Rayner C; Horowitz M; Holtmann G; Talley N; Windsor J; Pirola R; Neale R, 2016, 'Summary and recommendations from the Australasian guidelines for the management of pancreatic exocrine insufficiency', Pancreatology, vol. 16, pp. 164 - 180, http://dx.doi.org/10.1016/j.pan.2015.12.006

Ooi CY; Durie PR, 2016, 'Cystic fibrosis from the gastroenterologist's perspective', Nature Reviews Gastroenterology and Hepatology, vol. 13, pp. 175 - 185, http://dx.doi.org/10.1038/nrgastro.2015.226

Widger J; Hameed S; Ooi CY; Verge C, 2016, 'Using HbA1c as a screening tool for Cystic Fibrosis Related Diabetes', Journal of Cystic Fibrosis, vol. 15, pp. 263 - 264, http://dx.doi.org/10.1016/j.jcf.2015.10.009

Safe M; Gifford AJ; Jaffe A; Ooi CY, 2016, 'Resolution of intestinal histopathology changes in cystic fibrosis after treatment with ivacaftor', Annals of the American Thoracic Society, vol. 13, pp. 297 - 298, http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201510-669LE?journalCode=annalsats

Husain SZ; Morinville V; Pohl J; Abu-El-Haija M; Bellin MD; Freedman S; Hegyi P; Heyman MB; Himes R; Ooi CY; Schwarzenberg SJ; Usatin D; Uc A, 2016, 'Toxic-metabolic risk factors in pediatric pancreatitis: Recommendations for diagnosis, management, and future research', Journal of Pediatric Gastroenterology and Nutrition, vol. 62, pp. 609 - 617, http://dx.doi.org/10.1097/MPG.0000000000001035

Ting J; Wilson L; Schwarzenberg SJ; Himes R; Barth B; Bellin MD; Durie PR; Fishman DS; Freedman SD; Gariepy CE; Giefer MJ; Gonska T; Husain SZ; Kumar S; Morinville VD; Lowe ME; Ooi CY; Pohl JF; Troendle D; Usatin D; Werlin SL; Wilschanski M; Heyman MB; Uc A, 2016, 'Direct costs of acute recurrent and chronic pancreatitis in children in the INSPPIRE registry', Journal of Pediatric Gastroenterology and Nutrition, vol. 62, pp. 443 - 449, http://dx.doi.org/10.1097/MPG.0000000000001057

Ooi CY; Pang T; Leach ST; Katz T; Day AS; Jaffe A, 2015, 'Fecal Human β-Defensin 2 in Children with Cystic Fibrosis: Is There a Diminished Intestinal Innate Immune Response?', Digestive Diseases and Sciences, vol. 60, pp. 2946 - 2952, http://dx.doi.org/10.1007/s10620-015-3842-2

Pang T; Leach ST; Katz T; Jaffe A; Day AS; Ooi CY, 2015, 'Elevated fecal M2-pyruvate kinase in children with cystic fibrosis: A clue to the increased risk of intestinal malignancy in adulthood?', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 30, pp. 866 - 871, http://dx.doi.org/10.1111/jgh.12842

Tan LZ; Adams SE; Kennedy A; Kepreotes H; Ooi CY, 2015, 'Are children on jejunal feeds at risk of iron deficiency?', World Journal of Gastroenterology, vol. 21, pp. 5751 - 5754, http://dx.doi.org/10.3748/wjg.v21.i18.5751

Ooi CY; Castellani C; Keenan K; Avolio J; Volpi S; Boland M; Kovesi T; Bjornson C; Chilvers MA; Morgan L; Van Wylick R; Kent S; Price A; Solomon M; Tam K; Taylor L; Malitt KA; Ratjen F; Durie PR; Gonska T, 2015, 'Inconclusive diagnosis of cystic fibrosis after newborn screening', Pediatrics, vol. 135, pp. e1377 - e1385, http://dx.doi.org/10.1542/peds.2014-2081

Schwarzenberg SJ; Bellin M; Husain SZ; Ahuja M; Barth B; Davis H; Durie PR; Fishman DS; Freedman SD; Gariepy CE; Giefer MJ; Gonska T; Heyman MB; Himes R; Kumar S; Morinville VD; Lowe ME; Nuehring NE; Ooi CY; Pohl JF; Troendle D; Werlin SL; Wilschanski M; Yen E; Uc A, 2015, 'Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden', Journal of Pediatrics, vol. 166, pp. 890 - 896.e1, http://dx.doi.org/10.1016/j.jpeds.2014.11.019

Ooi CY; Ratjen F; Gonska T, 2015, 'Re: Stratifying cystic fibrosis risk for newborn screen infants with equivocal sweat chloride levels', Pediatrics, vol. 136, pp. e1490 - e1491, http://dx.doi.org/10.1542/peds.2015-2786B

Ooi CY, 2014, 'Cystic Fibrosis in the Genomic Era: CFTR Genotyping as a Diagnostic Test', Journal of Pulmonary & Respiratory Medicine, http://dx.doi.org/10.4172/2161-105X.1000222

Pang T; Leach ST; Katz T; Day AS; Ooi CY, 2014, 'Fecal biomarkers of intestinal health and disease in children', Frontiers in Pediatrics, vol. 2, pp. 1 - 12, http://dx.doi.org/10.3389/fped.2014.00006

Ooi CY; Dupuis A; Ellis L; Jarvi K; Martin S; Ray PN; Steele L; Kortan P; Gonska T; Dorfman R; Solomon M; Zielenski J; Corey M; Tullis E; Durie P, 2014, 'Does extensive genotyping and nasal potential difference testing clarify the diagnosis of cystic fibrosis among patients with single-organ manifestations of cystic fibrosis?', Thorax, vol. 69, pp. 254 - 260, http://dx.doi.org/10.1136/thoraxjnl-2013-203832

Ooi CY; Dupuis A; Gonska T; Ellis L; Ni A; Jarvi K; Martin S; Ray P; Steele L; Kortan P; Dorfman R; Solomon M; Zielenski J; Corey M; Tullis E; Durie P, 2014, 'Does integration of various ion channel measurements improve diagnostic performance in cystic fibrosis?', Annals of the American Thoracic Society, vol. 11, pp. 562 - 570, http://dx.doi.org/10.1513/AnnalsATS.201311-412OC

Coffey MJ; Nightingale S; Ooi CY, 2014, 'Diagnosing acute pancreatitis in children: What is the diagnostic yield and concordance for serum pancreatic enzymes and imaging within 96 h of presentation?', Pancreatology, vol. 14, pp. 251 - 256, http://dx.doi.org/10.1016/j.pan.2014.05.383

Morinville VD; Lowe ME; Ahuja M; Barth B; Bellin MD; Davis H; Durie PR; Finley B; Fishman DS; Freedman SD; Gariepy CE; Giefer MJ; Gonska T; Heyman MB; Himes R; Husain S; Kumar S; Ooi CY; Pohl JF; Schwarzenberg SJ; Troendle D; Werlin SL; Wilschanski M; Yen E; Uc A, 2014, 'Design and implementation of INSPPIRE', Journal of Pediatric Gastroenterology and Nutrition, vol. 59, pp. 360 - 364, http://dx.doi.org/10.1097/MPG.0000000000000417

Coffey MJ; Nightingale S; Ooi CY, 2014, 'Authors’ Response', Journal of Pediatric Gastroenterology and Nutrition, vol. 58, pp. e42 - e42, http://dx.doi.org/10.1097/MPG.0000000000000308

Pang T; Leach ST; Katz T; Jaffe A; Day AS; Ooi CY, 2014, 'Elevated faecal M2-pyruvate kinase in children with cystic fibrosis: A clue to the increased risk of intestinal malignancy in adulthood?', Journal of Gastroenterology and Hepatology, vol. 30, pp. n/a - n/a, http://dx.doi.org/10.1111/jgh.12842

Dhaliwal J; Leach S; Katz T; Nahidi L; Pang T; Lee JM; Strachan R; Day AS; Jaffe A; Ooi CY, 2014, 'Intestinal Inflammation and Impact on Growth in Children With Cystic Fibrosis', Journal of Pediatric Gastroenterology and Nutrition, vol. 60, pp. 1 - 1, http://dx.doi.org/10.1097/MPG.0000000000000683

Coffey MJ; Nightingale S; Ooi CY, 2013, 'Predicting a biliary aetiology in paediatric acute pancreatitis', Archives of Disease in Childhood, vol. 98, pp. 965 - 969, http://dx.doi.org/10.1136/archdischild-2013-304462

Ledder OD; Lemberg DA; Ooi CY; Day AS, 2013, 'Are thiopurines always contraindicated after thiopurine-induced pancreatitis in inflammatory bowel disease?', Journal of Pediatric Gastroenterology and Nutrition, vol. 57, pp. 583 - 586, http://dx.doi.org/10.1097/MPG.0b013e31829f16fc

Meyer A; Coffey MJ; Oliver MR; Ooi CY, 2013, 'Contrasts and comparisons between childhood and adult onset acute pancreatitis', Pancreatology, vol. 13, pp. 429 - 435, http://dx.doi.org/10.1016/j.pan.2013.06.005

Coffey MJ; Nightingale S; Ooi CY, 2013, 'Serum Lipase as an Early Predictor of Severity in Pediatric Acute Pancreatitis', Journal of Pediatric Gastroenterology and Nutrition, vol. 56, pp. 602 - 608, http://dx.doi.org/10.1097/MPG.0b013e31828b36d8

Morinville VD; Husain SZ; Bai H; Barth B; Alhosh R; Durie PR; Freedman SD; Himes R; Lowe ME; Pohl J; Werlin S; Wilschanski M; Uc A, 2012, 'Definitions of pediatric pancreatitis and survey of present clinical practices', Journal of Pediatric Gastroenterology and Nutrition, vol. 55, pp. 261 - 265, http://dx.doi.org/10.1097/MPG.0b013e31824f1516

Ooi CY; Nightingale S; Durie PR; Freedman SD, 2012, 'Ursodeoxycholic acid in cystic fibrosis-associated liver disease', Journal of Cystic Fibrosis, vol. 11, pp. 72 - 73, http://dx.doi.org/10.1016/j.jcf.2011.08.002

Lee JM; Leach ST; Katz T; Day AS; Jaffe A; Ooi CY, 2012, 'Update of faecal markers of inflammation in children with cystic fibrosis', Mediators of Inflammation, vol. 2012, pp. Article number: 948367, http://dx.doi.org/10.1155/2012/948367

Yap T; Jiwane ; Belessis Y; Ooi CY, 2012, 'Colonic atresia presenting as neonatal bowel obstruction in cystic fibrosis', Journal of Pediatric Gastroenterology and Nutrition, vol. 58, http://dx.doi.org/10.1097/MPG.0b013e3182769768

Gonska T; Choi P; Stephenson A; Ellis L; Martin S; Solomon M; Dupuis A; Dorfman R; Zielenski J; Ooi CY; Weiser W; Durie P; Tullis ED, 2012, 'Role of cystic fibrosis transmembrane conductance regulator in patients with chronic sinopulmonary disease', Chest, vol. 142, pp. 996 - 1004, http://dx.doi.org/10.1378/chest.11-2543

Ooi CY; Durie P, 2012, 'Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in pancreatitis', Journal of Cystic Fibrosis, vol. 11, pp. 355 - 362, http://dx.doi.org/10.1016/j.jcf.2012.05.001

Ooi CY; Dupuis A; Ellis LE; Jarvi KA; Martin SM; Gonska T; Dorfman R; Kortan PP; Solomon MP; Tullis ED; Durie PR, 2012, 'Comparing the American and European diagnostic guidelines for cystic fibrosis: Same disease, different language?', Thorax, vol. 67, pp. 618 - 624, http://dx.doi.org/10.1136/thoraxjnl-2011-201454

Whitten K; Rogers P; Ooi CY; Day AS, 2012, 'International survey of enteral nutrition protocols used in children with Crohn's disease', Journal of Digestive Diseases, vol. 13, pp. 107 - 112, http://dx.doi.org/10.1111/j.1751-2980.2011.00558.x

Ooi CY; Dorfman R; Cipolli M; Gonska T; Castellani C; Keenan K; Freedman SD; Zielenski J; Berthiaume Y; Corey M; Schibli S; Tullis E; Durie PR, 2011, 'Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis', Gastroenterology, vol. 140, pp. 153 - 161, http://dx.doi.org/10.1053/j.gastro.2010.09.046

Ooi CY; Brody D; Wong R; Moroz S; Ngan B; Navarro O; Fecteau A; Grant D; Ng V, 2010, 'Liver Transplantation for Massive Hepatic Lympangiomatosis', Journal of Pediatric Gastroenterology and Nutrition, vol. 52, pp. 366 - 369, http://dx.doi.org/10.1097/MPG.0b013e3181ec1cfb

Ooi CY; Brandao L; Zolpys L; De angelis M; Drew W; Jones N; Ling S; Fecteau A; Ng V, 2010, 'Thrombotic events after pediatric liver transplantation', Pediatric Transplantation, vol. 14, pp. 476 - 482, http://dx.doi.org/10.1111/j.1399-3046.2009.01252.x

Ooi CY; Gonska T; Durie P; Freedman S, 2010, 'Genetic Testing in Pancreatitis', Gastroenterology, vol. 138, pp. 2202 - 2206, http://dx.doi.org/10.1053/j.gastro.2010.04.022

Gray T; Ooi CY; Tran D; Traubici J; Gerstle JT; Sung L, 2010, 'Gastrointestinal complications in children with acute myeloid leukemia', Leukemia and Lymphoma, vol. 51, pp. 768 - 777, http://dx.doi.org/10.3109/10428191003695652

Ooi CY; Dilley AV; Day AS, 2009, 'Saccharomyces boulardii in a child with recurrent Clostridium difficile', Pediatrics International, vol. 51, pp. 156 - 158, http://dx.doi.org/10.1111/j.1442-200X.2008.02782.x

Ooi CY; Day AS; Jackson R; Bohane TD; Tobias VH; Lemberg DA, 2008, 'Eosinophilic esophagitis in children with celiac disease', Journal of Gastroenterology and Hepatology, vol. 23, pp. 1144 - 1148, http://dx.doi.org/10.1111/j.1440-1746.2007.05239.x

Ooi CY; Bohane TD; Lee DJ; Naidoo D; Day AS, 2007, 'Thiopurine metabolite monitoring in paediatric inflammatory bowel disease', Alimentary Pharmacology and Therapeutics, vol. 25, pp. 941 - 947, http://dx.doi.org/10.1111/j.1365-2036.2007.03278.x

Lemberg DA; Ooi CY; Day AS, 2007, 'Probiotics in paediatric gastrointestinal diseases', Journal of Paediatrics and Child Health (Vol. 48, Suppl. 2, 2012, 1–13), vol. 43, pp. 331 - 336, http://dx.doi.org/10.1111/j.1440-1754.2007.01076.x

Conference Papers

Dike CR; Zimmerman B; Wilschanski M; Werlin SL; Troendle DM; Shah U; Schwarzenberg SJ; Rhee SJ; Pohl JF; Perito ER; Ooi CY; Nathan JD; Morinville VD; McFerron B; Mascarenhas MR; Maqbool A; Liu Q; Lin TK; Husain SZ; Himes R; Heyman MB; Gonska T; Giefer MJ; Gariepy CE; Freedman SD; Fishman DS; Bellin MD; Barth B; Abu-El-Haija M; Lowe ME; Uc A, 2018, 'Regional Variations in Clinical Characteristics and Management of Pediatric Acute Recurrent and Chronic Pancreatitis: Report From the INSPPIRE Study', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, pp. 1383 - 1384, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449304600084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Coffey MJ; Zhong L; Jaffe A; Ooi CY; Waters S, 2018, 'The human intestinal proteome in children with cystic fibrosis', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 144 - 144, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000530647800252&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cone S; Larkin G; Poulton C; Wemheuer B; Thomas T; Lemberg D; Gupta N; Leach ST; Coffey MJ; Ooi CY, 2018, 'Functional dysbiosis of the gut microbiota in childhood irritable bowel syndrome', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 144 - 145, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000530647800253&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Garg M; Leach S; Needham B; Coffey MJ; Katz T; Strachan R; Widger J; Field P; Belessis Y; Chuang S; Day AS; Jaffe A; Ooi KY, 2017, 'Determining the age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis during the first decade of life.', in Widger J, Field P, Belessis Y, Chuang S, Day AS, Jaffe A, Ooi CY., W B SAUNDERS CO-ELSEVIER INC, Spain, pp. S645 - S646, presented at European Cystic Fibrosis Conference Society, Spain, 08 June 2017 - 10 June 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403140302488&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Sutherland R; Katz T; Liu V; Quintano J; Brunner R; Tong C; Collins C; Ooi K, 2017, 'Dietary intake of energy-dense, nutrient-poor, and nutrient-dense food sources in Australian children with cystic fibrosis.', in Sutherland R, Katz T, Liu V, Quintano J, Brunner R, Tong C, Collins C,, Spain, pp. 804 - 810, presented at European Cystic Fibrosis Society Conference, Spain, 07 June 2017 - 10 June 2017, http://dx.doi.org/10.1016/j.jcf.2018.03.011

Sutherland R; Collins C; Brunner R; Ooi KY; Katz T, 2017, 'An historical perspective of dietary intake studies in children with cystic fibrosis.', in Sutherland R, Collins C, Brunner R, Ooi CY, Katz T., European Cystic Fibrosis Society Conference, Spain, presented at European Cystic Fibrosis Society Conference, Spain, 08 June 2017 - 10 June 2017

Garg M; Leach S; Coffey MJ; Katz T; Strachan R; Pang T; Needham B; Lui K; Day AS; Appleton L; Moeeni V; Jaffe A; Ooi KY, 2017, 'Age-dependent levels of fecal calprotectin in cystic fibrosis and healthy children.', in Age-dependent levels of fecal calprotectin in cystic fibrosis and healthy children., European Cystic Fibrosis Society Conference, Spain, presented at European Cystic Fibrosis Society Conference, Spain, 08 June 2017 - 10 June 2017

Ooi CY; Sutherland RE; Keenan K; Castellani C; van Wylick R; Price A; Boland M; Reisman J; Zuberbuhler P; Bjornson C; Chilvers M; Brusky J; Mateos-Corral D; Hughes D; Morgan L; Durie PR; Ratjen F; Gonska T, 2016, 'THE ROLE OF LABORATORY TESTS IN CHILDREN WITH AN UNCERTAIN DIAGNOSIS OF CF FOLLOWING POSITIVE NEWBORN SCREENING', in PEDIATRIC PULMONOLOGY, WILEY-BLACKWELL, pp. 386 - 386, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000384815300579&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ooi KY, 2015, 'Clinical manifestations of pancreatitis in classic and atypical CF.', in Clinical manifestations of pancreatitis in classic and atypical CF., North American Cystic Fibrosis Conference, USA, presented at North American Cystic Fibrosis Conference, USA, 08 October 2015 - 10 October 2015

Ooi KY, 2012, 'The pancreas in cystic fibrosis…..and how to diagnose cystic fibrosis.', in Proceedings of the Australian Health and Medical Research Congress 2012, The Australian Health and Medical Research Congress, pp. 159, presented at The Australian Health and Medical Research Congress, 25 November 2012 - 28 November 2012

Ooi CY; Durie PR, 2012, 'CF by the books...sweat test, genotype, clinical presentation', in CF by the books...sweat test, genotype, clinical presentation, Wiley Periodicals Inc., Orange County Convention Center Orlando, Florida, pp. 1 - 463, presented at 26th Annual North American Cystic Fibrosis Conference, Orange County Convention Center Orlando, Florida, 11 October 2012 - 13 October 2012, http://dx.doi.org/10.1002/ppul.22679

Ooi CY, 2012, 'The pancreas in pancreatic sufficient cystic fibrosis', in The pancreas in pancreatic sufficient cystic fibrosis, Wiley Periodicals Inc., Orange County Convention Center Orlando, Florida, pp. 1 - 463, presented at 26th Annual North American Cystic Fibrosis Conference, Orange County Convention Center Orlando, Florida, 11 October 2012 - 13 October 2012, http://dx.doi.org/10.1002/ppul.22679

Conference Presentations

Conference Abstracts

Reports

Ooi KY, 2017, Age-dependent variation of fecal calprotectin in cystic fibrosis and healthy children., https://www.ecfs.eu/sites/default/files/cf-research-article-files/JCF-D-17-00023R1_FINAL_Garg_20042017_0.pdf

Other

Tan LZ; Kwok SC; Ooi CY, 2015, Coeliac disease in Chinese children, http://dx.doi.org/10.1111/jpc.12894

School of Women's and Children's Health

Associate Professor (Keith) Chee Ooi

Tabs

Study @ WCH

Research @ WCH

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