Dr Alla Dolnikov

Tabs

Main

Contact Category:

Conjoint

Discipline:

Paediatrics

Alla Dolnikov, PhD, is Principal Hospital Scientist and project leader in the Blood and Marrow Transplant Research Laboratory at Sydney Children’s Hospital. She also teaches post-graduate students at the UNSW as a Senior Lecturer at the Faculty of Medicine supervising post-graduate students conducting their Honour, Master’s and PhD projects. Dr Dolnikov has done her PhD in Histology and Embryology. For the last 20 years Dr Dolnikov is developing gene therapy for leukaemia and solid tumours. In 2012 her groups has started the new project developing novel experimental immunotherapy that employs patient’s own immune cells genetically modified in laboratory with the chimeric molecules allowing them recognise tumour cells.

Dr Dolnikov has strong expertise in gene and cellular therapy obtained while performing her research in collaboration with Johnson & Johnson Research developing the new gene therapy technology targeting haematopoietic stem cells. This collaboration was extremely productive and resulted in several important publications in high profile journals in the areas of stem cell biology, cancer research and gene therapy including Blood, Leukaemia, Cancer Research, Oncogene, Stem Cells etc. Dr Dolnikov continued her research at Children’s Cancer Institute Australia for Medical Research as Senior Scientist leading Leukaemia Gene Therapy group. She continues her affiliation with the industry, her recent proposal was approved by the research committee of Novartis.

School:

Sch Women's&Children's Health

Phone:

02 9382 1879

Email:

Alla.Dolnikov@health.nsw.gov.au

University role:

Conjoint Senior Lecturer

Qualifications:

Dr Dolnikov has done her PhD in Histology and Embryology. For the last 20 years Dr Dolnikov is developing gene therapy for leukaemia and solid tumours.

Grants:

Dr Dolnikov has demonstrated productivity in attracting independent grants including 10 project grants as a CIA, 2 grants as CIB and 3-year Project Grant from the Cancer Council NSW as a single CI. During the last 10 years Dr Dolnikov alone or in the partnership with Dr O’Brien has attracted more than $1,250,000 of external funding for group’s research.

Current grants:

Kids Cancer Project Grant (2016-2019)
Inner Wheel Foundation Project Grant (2017)

Research

Research activities:

Dr Dolnikov’s team is involved in the pre-clinical development of the novel immune therapies for cancer including adoptive T cell therapy and checkpoint inhibitors. Dr Dolnikov’s team is conducting the collaborative research with the clinicians from SCH and Westmead hospitals. Additionally, Dr Dolnikov collaborates with the scientists from CCIA developing novel mouse models for the testing of novel experimental immunotherapies and small molecule drugs. These “humanised” immune competent mice are generated using human stem cells reconstituting fully functional human immune system in immune compromised mice. Dr Dolnikov’s team is also testing the combinations of targeted therapies and immune therapies to prolong anti-tumour responses.

Dr Dolnikov has established collaboration with Dr Kenneth Micklethwaite and Dr David Gottlieb, both from Westmead Hospital, Sydney, who are the experts in adoptive T cell therapy. Established collaborations with Prof Luca Dotti and Prof Malcolm Brenner from Baylor College of Medicine both of whom are internationally recognised experts in genetic modification of haematopoietic stem cells and T cells and pioneers in immunotherapy for cancer using chimeric antigen receptor (CAR)-modified T cells. In addition, I established novel collaboration with Dr Clemenceau from INSERM CRCNA, France, known for her expertise in genetic modification of human leukocytes.

Publications: Over 47 publications in international peer reviewed journals including Blood, Stem Cells, Cancer Research, Leukaemia, Oncogene, Current Medicinal Chemistry, Experimental haematology, Stem Cells & Development.
Published 4 invited review articles and 3 book chapters.
H-index 18

Field of Research (FOR) Tag:

Haematological Tumours

Tumour Immunology

Transplantation Immunology

Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

Dr Dolnikov successfully supervised 2 MSc, 4 PhD and 3 Honours students to date. One PhD student, Guy Klamer, became a NSW finalist of AusBiotech-GlaxoSmith Kline Student Excellence Award (2011), obtained scholarship from Financial Markets for Children Foundation (2010-2011) as well as the UNSW Post-graduate Research Support Scheme Conference Travel Grant. Another PhD student, Tiffany Holmes has also received several conference travel awards.

PhD, Masters:

Novel Immune therapies for cancer

Currently supervising:

At the moment, Dr Dolnikov supervises 2 PhD students.

Media

Facebook:

https://www.facebook.com/UNSWWomensChildrensHealth

Twitter Account:

https://twitter.com/UNSWObGyn_Paeds

Publications related to this Person

Book Chapters

Ko KH; Nordon R; O Brien TA; Symonds G; Dolnikov A, 2017, 'Ex vivo expansion of hematopoietic stem cells to improve engraftment in stem cell transplantation', in Methods in Molecular Biology, pp. 301 - 311, http://dx.doi.org/10.1007/978-1-4939-6603-5_19

Dolnikov A; O'Brien TA; Xu N; Shen S; Klamer G, 2014, 'Strategies to improve immune reconstitution after haematopoeitic stem cell transplantation.', in Rahman A; Anjum S (ed.), Frontiers in Stem Cell and Regenerative Medicine Research, vol. 1, Bentham Science, pp. 30 - 64, http://dx.doi.org/10.2174/97816080599421150101

Ko K; Nordon R; O Brien T; Symonds G; Dolnikov A, 2011, 'Ex Vivo Expansion of Haematopoietic Stem Cells to Improve Engraftment in Stem Cell Transplantation', in Humana Press (ed.), Cell Cycle Synchronization, Springer, New York, pp. 249 - 260, http://dx.doi.org/10.1007/978-1-61779-182-6_17

Journal articles

Dolnikov A; Xu N; Shen S; Song E; Holmes T; Klamer G; O'Brien TA, 2014, 'GSK-3β inhibition promotes early engraftment of ex vivo-expanded haematopoietic stem cells', Cell Proliferation, vol. 47, pp. 113 - 123, http://dx.doi.org/10.1111/cpr.12092

Shen S; Xu N; Klamer G; O'Brien TA; Dolnikov A, 2013, 'NOVEL APPROACH TO GENERATE CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS USING GENETICALLY MODIFIED T CELL PRECURSORS', CYTOTHERAPY, vol. 15, pp. S54 - S54, http://dx.doi.org/10.1016/j.jcyt.2013.01.211

Klamer G; Shen S; Song E; Rice AM; Knight R; Lindeman R; O'Brien TA; Dolnikov A, 2013, 'GSK3 inhibition prevents lethal GVHD in mice', Experimental Hematology, vol. 41, http://dx.doi.org/10.1016/j.exphem.2012.09.005

Shen S; Xu N; O'Brien TA; Dolnikov A; Klamer G, 2013, 'GSK-3β inhibition preserves naive T cell phenotype in bone marrow reconstituted mice', Experimental Hematology, vol. 41, pp. 1016 - 1027, http://dx.doi.org/10.1016/j.exphem.2013.08.006

Holmes TA; Yan F; Ko K; Nordon RE; Song YE; O Brien T; Dolnikov A, 2012, 'Ex vivo expansion of cord blood progenitors impairs their short-term and long-term repopulating activity associated with transcriptional dysregulation of signalling networks', Cell Proliferation, vol. 45, pp. 266 - 278, http://dx.doi.org/10.1111/j.1365-2184.2012.00813.x

Ko K; Holmes TA; Palladinetti P; Song E; Nordon RE; O Brien T; Dolnikov A, 2011, 'GSK-3β Inhibition Promotes Engraftment of Ex Vivo-Expanded Hematopoietic Stem Cells and Modulates Gene Expression', Stem Cells, vol. 29, pp. 108 - 118, http://dx.doi.org/10.1002/stem.551

Song EY; Palladinetti P; Klamer G; Ko K-H; Lindeman R; O'Brien TA; Dolnikov A, 2010, 'Glycogen synthase kinase−3β inhibitors suppress leukemia cell growth', Experimental Hematology, vol. 38, pp. 908 - 921, http://dx.doi.org/10.1016/j.exphem.2010.06.001

Klamer G; Song EY; Ko K; O Brien T; Dolnikov A, 2010, 'Using Small Molecule GSK3 beta Inhibitors to Treat Inflammation', Current Medicinal Chemistry: Cardiovascular and Hematological Agents, vol. 17, pp. 2873 - 2881, http://dx.doi.org/10.2174/092986710792065090

Choo A; Palladinetti P; Holmes TA; Basu S; Shen S; Lock RB; O Brien T; Symonds GP; Dolnikov A, 2008, 'siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth.', International Journal of Oncology, vol. 33, pp. 175 - 183

Holmes TA; O Brien T; Knight RJ; Lindeman R; Symonds G; Dolnikov A, 2008, 'The role of glycogen synthase kinase-3 beta in normal haematopoiesis, angiogenesis and leukaemia', Current Medicinal Chemistry: Cardiovascular and Hematological Agents, vol. 15, pp. 1493 - 1499, http://dx.doi.org/10.2174/092986708784638834

Holmes TA; O Brien T; Knight RJ; Lindeman R; Shen S; Song YE; Symonds GP; Dolnikov A, 2008, 'Glycogen synthase kinase-3 beta inhibition preserves hematopoietic stem cell activity and inhibits leukemic cell growth', Stem Cells, vol. 26, pp. 1288 - 1297, http://dx.doi.org/10.1634/stemcells.2007-0600

Shen S; Passioura TJ; Symonds GP; Dolnikov A, 2007, 'N-ras oncogene-induced gene expression in human hematopoietic progenitor cells: Upregulation of p16INK4a and p21CIP1/WAF1 correlates with myeloid differentiation', Experimental Hematology, vol. 35, pp. 908 - 919, http://dx.doi.org/10.1016/j.exphem.2007.02.011

Choo A; Palladinetti P; Passioura TJ; Shen S; Symonds GP; Dolnikov A, 2006, 'The role of IRF1 and IRF2 transcription factors in leukaemogenesis', Current Gene Therapy, vol. 6, pp. 543 - 550, http://dx.doi.org/10.2174/156652306778520683

Passioura TJ; Shen S; Symonds GP; Dolnikov A, 2005, 'A retroviral library genetic screen identitifies IRF-2 as an inhabitor of N-ras induced growth suppervision in leukemai cells', Oncogene, vol. 24, pp. 7327 - 7336, http://dx.doi.org/10.1038/sj.onc.1208877

Passioura TJ; Dolnikov A; Shen S; Symonds GP, 2005, 'N-ras induced growth suppression of myeloid cells is mediated by IRF-1', Cancer research, vol. 65, pp. 797 - 804

Shen S; Passioura ; Choo A; Symonds G; Dolnikov A, 2005, 'Targeting the IRF2 transcription factor to inhibit leukaemic cell growth', Journal of Gene Medicine, vol. 7, pp. 1135 - 1135, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231477900071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Shen S; Passioura TJ; Choo A; Symonds GP; Dolnikov A, 2005, 'Mutant N-ras activation in primary human hemaopoietic progenitor cells: biologic, phenotypic and genetic sequelae', EJC Supplements, vol. 3, pp. 285 - 285, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000247564801146&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Wotherspoon S; Dolnikov A; Symonds GP; Nordon RE, 2004, 'Susceptibility of cell populations to transduction by retroviral vectors', Journal of Virology, vol. 78, pp. 5097 - 5102, http://dx.doi.org/10.1128/JVI.78.10.5097-5102.2004

Shen SC; Dolnikov A; Passioura TJ; Millington M; Wotherspoon S; Rice AM; Mackenzie K; Symonds GP, 2004, 'Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid proliferation both in vitro and in the NOd/SCID mouse.', Experimental Hematology, vol. 32, pp. 852 - 860, http://dx.doi.org/10.1016/j.exphem.2004.06.001

Dolnikov A; Wotherspoon S; Millington M; Symonds G, 2003, 'Retrovirus vector production and transduction: Modulation by the cell cycle', Journal of General Virology, vol. 84, pp. 3131 - 3141, http://dx.doi.org/10.1099/vir.0.19099-0

Dolnikov A; Shen S; Millington M; Passioura T; Pedler M; Rasko JEJ; Symonds G, 2003, 'A sensitive dual-fluorescence reporter system enables positive selection of ras suppressors by suppression of ras-induced apoptosis', Cancer Gene Therapy, vol. 10, pp. 745 - 754, http://dx.doi.org/10.1038/sj.cgt.7700603

Dolnikov A; Shen SC; Passioura TJ; Symonds GP, 2003, 'Bone marrow reconstituiton as a relevant model of genetically programmd leukemia', Current Medicinal Chemistry: Cardiovascular and Hematological Agents, vol. 1, pp. 83 - 97, http://dx.doi.org/10.2174/1568016033477531

Dolnikov A; Shen S; Passioura TJ; Symonds GP, 2003, 'Genetic control of hematopoietic stem cell biology and leukemogenesis', Blood, vol. 102, pp. 332A - 332A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000186536701194&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Dolnikov A; Millington M; Beruter E; Shounan Y; Symonds G, 2000, 'The β-galactosidase gene as a marker for hematopoietic reconstitution: Individual cell analysis in a murine bone marrow transplantation model', Journal of Hematotherapy and Stem Cell Research, vol. 9, pp. 659 - 672, http://dx.doi.org/10.1089/15258160050196704

Dolnikov A; Millington M; Sun LQ; Symonds G, 2000, 'Induced p21^(WAF1) expression acts to reverse myc myelomonocytic cell transformation', Cancer Gene Therapy, vol. 7, pp. 1491 - 1503, http://dx.doi.org/10.1038/sj.cgt.7700229

Dolnikov A; Millington M; Sun L; Symonds GP, 2000, 'Induced p21 WAF1 expression acts to reverse myc myelomonocytic cell transformation', Cancer Gene Therapy, pp. 1492 - 1503

Dolnikov A; Millington M; Sun L; Symonds GP, 2000, 'Induced p21 WAFI expression acts to reverse myc myeoomomocytic cell transformation', Cancer Gene Therapy, pp. 1492 - 1503

Dolnikov A; Millington M; Beruter E; Yi S; Symonds GP, 2000, 'The beta-galactosidase gene as a marker for hematopoietic reconstitution: individual cell analysis in a muring bone marrow transplantation', Journal of Hematotherapy and Stem Cell Research, pp. 659 - 672

Dolnikov A; Millington M; Beruter E; Symonds GP; Yi S, 2000, 'The beta-galactosidase gene as a marker for hematopoietic reconstitution: individual cell analysis in a murine bone marrow transplantation', Journal of Hematotherapy and Stem Cell Research, vol. 9, pp. 659 - 672, http://dx.doi.org/10.1089/15258160050196704

Mackenzie K; Dolnikov A; Millington M; Yi S; Symonds GP, 1999, 'Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice', Blood, vol. 93, pp. 2043 - 2056

Dolnikov A; Yi S; Millington M; Mackenzie K; Symonds GP, 1998, 'V-myc in a simple, single gene retroviral vector causes rapid induction of leukemia and concomitant apoptosis following bone marrow transplantation', Leukemia, vol. 12, pp. 542 - 553, http://dx.doi.org/10.1038/sj.leu.2400968

Shounan Y; MacKenzie K; Dolnikov A; Miller M; Symonds G, 1997, 'Myeloproliferative disease and myelodysplastic syndrome induced by transplantation of bone marrow cells expressing mutant p53', Leukemia, vol. 11, pp. 1641 - 1649, http://dx.doi.org/10.1038/sj.leu.2400782

Du ZY; Dolnikov A; Hicks M; Macdonald PS, 1997, 'Enhanced preservation of the rat heart after prolonged hypothermic storage with the21-aminosteriod U74500A', Asia Pacific Heart Journal, vol. 6, pp. 184 - 189, http://dx.doi.org/10.1016/S1328-0163(97)90028-2

Shounan Y; Dolnikov A; MacKenzie KL; Miller M; Chan YY; Symonds G, 1996, 'Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis', Leukemia, vol. 10, pp. 1619 - 1628

Dolnikov A; Ward RL; Hawkins NJ; Symonds G, 1996, 'Apoptosis in v-myc transformation of myelomonocytic cells and its modulation by CSF-1', Oncogene, vol. 12, pp. 1189 - 1198

Dolnikov A; King AD; Luxford C; Symonds G; Sun L, 1996, 'Ribozyme-mediated suppression of v-myc expression abrogates apoptosis in transformed monocytes', Cancer Gene Therapy, vol. 3, pp. 289 - 295, https://www.ncbi.nlm.nih.gov/pubmed/8894247

Yi S; Dolnikov A; MacKenzie KL; Miller M; Symonds G, 1995, 'Mutant p53 transformation of murine bone marrow-derived hematopoietic cells.', BLOOD, vol. 86, pp. 4021 - 4021, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995TH91004021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Yi S; Hawkins NJ; Ward RL; Symonds G, 1995, 'Transformation by v-erb-B: induction of apoptosis is abrogated in a myeloid cell line', International Journal of Oncology, vol. 6, pp. 633 - 638

Walsh D; Li K; Wass J; Dolnikov A; Zeng F; Zhe L; Edwards M, 1993, 'Heat‐shock gene expression and cell cycle changes during mammalian embryonic development', Developmental Genetics, vol. 14, pp. 127 - 136, http://dx.doi.org/10.1002/dvg.1020140207

Conference Papers

Bishop D; Xu N; Shen S; O'Brien T; Gottlieb D; Dolnikov A; Micklethwaite K, 2017, 'Preclinical optimization of a low cost PiggyBac transposase (PB) generated CD19-specific chimeric antigen receptor T cell (CART19) product for a first in man trial using local hospital cell manufacture', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.AM2017-3760

Shen S; Dolnikov A; O'Brien T, 2016, 'Ex vivo expansion of cytolitic natural killer cells in combined immune therapy for relapsed and refractory neuroblastoma', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, pp. 131 - 131, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400262&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Yang S; Shen S; Xu N; O'Brien T, 2016, 'Combined immune and epigenetic therapy for high risk and relapsed leukaemias and lymphomas', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, pp. 118 - 119, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400236&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Shen S; Xu N; Yang S; O'Brien T; Dolnikov A, 2016, 'Haematopoietic stem cells to generate chimeric antigen receptor (CAR)-modified T cells', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, pp. 119 - 119, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610400237&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Xu N; Shen S; O'Brien T; Dolnikov A, 2016, 'Increasing stem cell dose promotes immune reconstitution following stem cell transplant', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, Melbourne, AUSTRALIA, pp. 954 - 954, presented at International Congress of Immunology (ICI), Melbourne, AUSTRALIA, 21 August 2016 - 26 August 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000383610402309&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A, 2016, 'HAEMATOPOIETIC STEM CELL TRANSPLANTS ENHANCE CART CELL EXPANSION AND PERSISTENCE IN XENOGRAFT MOUSE MODEL', in CYTOTHERAPY, ELSEVIER SCI LTD, pp. S61 - S61, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000376222800162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Xu N; Yang S; O'Brien T, 2015, 'DECLINED PRESENTATION T-CELL PRECURSORS TO GENERATE CHIMERIC ANTIGEN RECEPTOR (CAR)-MODIFIED T CELLS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Kyoto, JAPAN, pp. S60 - S60, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, JAPAN, 17 September 2015 - 19 September 2015, http://dx.doi.org/10.1016/j.exphem.2015.06.110

Dolnikov A; Shen S; Xu N; Yang S; O'Brien T, 2015, 'DECLINED PRESENTATION STEM CELL APPROACH TO GENERATE CHIMERIC ANTIGEN RECEPTOR MODIFIED IMMUNE EFFECTOR CELLS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Kyoto, JAPAN, pp. S59 - S59, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, JAPAN, 17 September 2015 - 19 September 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361417400091&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Yang S; Shen S; Xu N; O'Brien T, 2015, 'DECLINED PRESENTATION ONE DOSE OF 5-AZA-2 '-DEOXYCYTIDINE ENHANCES THERAPEUTIC EFFICACY OF CART-CELL THERAPY IN A MURINE MODEL BY IMPROVING T-CELL PERSISTENCE', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Kyoto, JAPAN, pp. S59 - S59, presented at 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, JAPAN, 17 September 2015 - 19 September 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361417400092&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Rossi S; Xu N; Klamer G; Shen S; Micklethwaite KP; Lock RB; O'Brien T, 2014, '5-Aza-2 '-Deoxycytidine Promotes Cytotoxic Effect of CART-Cells on Leukaemia Cells', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2014 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349233806021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Sylvie S; Xu N; O'Brien T, 2014, 'Stem Cell Approach to Generate Chimeric Antigen Receptor Modified Immune Effector Cells to Treat Cancer', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, presented at 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2014 - 09 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349233807213&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Xu N; O'Brien T, 2014, 'STEM CELL APPROACH TO GENERATE MULTIPLE IMMUNE EFFECTOR CELLS TO TREAT CANCER', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 32 - 32, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100081&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Chitranjan A; Shen S; Klamer G; O'Brien T, 2014, 'TESTING CAR-T CELL ACTIVITY IN HUMAN HEMATOCHIMERIC MOUSE MODEL WITH THE NORMAL RANGE OF ANTIGEN EXPRESSION NOT RESCTRICTED TO THE TUMOUR ONLY', in CYTOTHERAPY, ELSEVIER SCI LTD, pp. S23 - S23, http://dx.doi.org/10.1016/j.jcyt.2014.01.072

Dolnikov A; Xu N; Shen S; O'Brien T, 2014, 'INCREASING STEM CELL DOSE PROMOTES THE LONGEVITY OF THE GRAFT IN MICE TRANSPLANTED WITH HUMAN CORD BLOOD STEM CELLS', in CYTOTHERAPY, ELSEVIER SCI LTD, pp. S57 - S57, http://dx.doi.org/10.1016/j.jcyt.2014.01.206

Dolnikov A; Shen S; Klamer G; Xu N; O'Brien TA, 2013, 'GSK-3 beta INHIBITION PROMOTES T CELL RECONSTITUTION AND PRESERVES NAIVE T CELL PHENOTYPE IN MICE TRANSPLANTED WITH HUMAN HAEMATOPOIETIC STEM CELLS', in CYTOTHERAPY, INFORMA HEALTHCARE, pp. S6 - S6, http://dx.doi.org/10.1016/j.jcyt.2013.01.020

Dolnikov A; Holmes T; Xu N; Shen S; Klamer G; O'Brien TA, 2013, 'TRANSIENT INHIBITION OF GSK-3,beta PROMOTES EARLY AND LATE ENGRAFTMENT OF EX VIVO EXPANDED HAEMATOPOIETIC PROGENITOR CELLS IN IMMUNO-COMPROMISED MICE', in CYTOTHERAPY, INFORMA HEALTHCARE, pp. S22 - S22, http://dx.doi.org/10.1016/j.jcyt.2013.01.081

Klamer G; O'Brien TA; Dolnikov A, 2011, 'THE POTENTIAL OF GSK3B INHIBITORS AS NOVEL THERAPEUTICS FOR GVHD', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. S22 - S23, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Klamer G; O'Brien TA, 2011, 'THERAPEUTIC TARGETING OF GSK3B MAY BECOME A STRATEGY IN PATIENTS RECEIVING STEM CELL TRANSPLANTATION FOR HEMATOLOGIC MALIGNANCIES', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. S81 - S82, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Song EY; Palladinetti P; Klamer G; Ko KH; Lindeman R; O'Brien TA; Dolnikov A, 2010, 'GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS SUPPRESS LEUKEMIA CELL GROWTH', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Melbourne, AUSTRALIA, pp. S48 - S48, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne, AUSTRALIA, 15 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Klamer GDH; Dolnikov A; O'Brien T; Palladinetti P; Song E; Ko KH, 2010, 'INVESTIGATING THE POTENTIAL OF PHARMACOCHEMICAL INHIBITION OF GSK3-BETA TO REDUCE THE BURDEN OF GVHD AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Melbourne, AUSTRALIA, pp. S35 - S35, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne, AUSTRALIA, 15 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Ko K-H; Song E; Holmes T; O'Brien TA, 2008, 'GSK-3 beta Inhibition Activates WNT, Delays Division and Preserves the Function in Hematopoietic Stem Cell', in BLOOD, AMER SOC HEMATOLOGY, San Francisco, CA, pp. 230 - 230, presented at 50th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, 06 December 2008 - 09 December 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000262104700617&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Knight RJ; O'Brien TA; Lindeman R; Dolnikov A, 2006, 'Novel role of activated ras in leukaemogenesis: Induction of angiogenesis.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 385A - 385A, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000242440001572&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Knight RJ; O'Brien TA; Lindeman R; Dolnikov A, 2006, 'Mutant Ras-expressing fibroblasts induce expansion of circulating angio- and lymphangiogenic precursor cells: Potential role in tumour vascularisation.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 389A - 389A, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000242440001590&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Holmes T; O'Brien TA, 2006, 'Glycogen synthase kinase-3 beta regulates ex-vivo expansion and engraftment of umbilical cord blood hematopietic stem cells through the activation of wnt signaling.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 105A - 106A, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://dx.doi.org/10.1182/blood.V108.11.340.340

Dolnikov A; Choo A; Palladinetti P; Passioura T; Symonds G; O'Brien TA, 2006, 'Targeting the IRF2 transcription factor to inhibit leukaemic cell growth.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 414A - 414A, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://dx.doi.org/10.1182/blood.V108.11.1425.1425

Dolnikov A; Holmes T; Shen S; Knight R; O'Brien TA, 2006, 'N-ras(m)-transduced fibroblasts facilitate the expansion and engraftment of umbilical cord blood stem cells.', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 912A - 912A, presented at 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 09 December 2006 - 12 December 2006, http://dx.doi.org/10.1182/blood.V108.11.3196.3196

O'Brien TA; Holmes T; Vowels M; Shen S; Symonds G; Dolnikov A, 2006, 'Novel approaches for the ex vivo expansion of the engraftable cord blood derived haematopoietic progenitor cells.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Holmes T; Symonds G; Brien TA, 2006, 'Molecular profile and functional analysis of the molecular factors derived from ras-transduced cells that regulate hematopoiesis.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600259&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Symonds G; Holmes TA; O'Brien TA, 2006, 'Stroma cells support ex vivo expansion of retrovirally transduced haematopoietic progenitor cells.', in CYTOTHERAPY, INFORMA HEALTHCARE, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Holmes T; O'Brien TA; Shen S; Choo A; Symonds G; Vowels M; Dolnikov A, 2006, 'Glycogen synthase kinase-3 regulates ex vivo expansion of human umbilical cord blood progenitor cells.', in CYTOTHERAPY, TAYLOR & FRANCIS AS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239337600054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Symonds G, 2005, 'Using a novel inhibitor of GSK-3 beta to activate the Wnt pathway in human haematopoietic stem cells: Impact on stem cell parameters', in CYTOMETRY PART A, WILEY-LISS, Queensland, AUSTRIA, pp. 415 - 416, presented at 7th Samuel A Latt Conference on Stem Cells in the Age of Fluorescence Technology, Queensland, AUSTRIA, 06 November 2005 - 09 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237187700065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Symonds G, 2005, 'Ras promotes engraftment of human haematopoietic stem cells through the activation of auto/paracrine mechanisms', in CYTOMETRY PART A, WILEY-LISS, Queensland, AUSTRIA, pp. 407 - 407, presented at 7th Samuel A Latt Conference on Stem Cells in the Age of Fluorescence Technology, Queensland, AUSTRIA, 06 November 2005 - 09 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237187700041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Shen S; Symonds G; Dolnikov A, 2005, 'An in vivo assay for retrovirally transduced human haematopoietic stem/progenitor cells (HSC/HPC) using nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice', in JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, Melbourne, AUSTRALIA, pp. 1135 - 1135, presented at 4th Meeting of the Australasian-Gene-Therapy-Society, Melbourne, AUSTRALIA, 27 April 2005 - 29 April 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000231477900072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dolnikov A; Shen S; Passioura T; Symonds G, 2003, 'Differential retroviral transduction of primitive hematopoietic progenitors rather than gene silencing accounts for variation in transgene expression', in JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS LTD, QUEENSLAND INST MED RES BRISBANE, BRISBANE, AUSTRALIA, pp. S13 - S14, presented at 3rd Meeting of the Australasian-Gene-Therapy-Society, QUEENSLAND INST MED RES BRISBANE, BRISBANE, AUSTRALIA, 30 April 2003 - 02 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183493100036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Shen SW; Dolnikov A; Passioura T; Symonds G; Bradstock KF, 2002, 'Mutant N-ras induces myeloid differentiation in human cord blood CD34+ cells', in BLOOD, AMER SOC HEMATOLOGY, PHILADELPHIA, PENNSYLVANIA, pp. 209B - 209B, presented at 44th Annual Meeting of the American-Society-of-Hematology, PHILADELPHIA, PENNSYLVANIA, 06 December 2002 - 10 December 2002, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000179184800888&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Symonds GP; Dolnikov A; Mackenzie K; Millington M; Yi S, 1997, 'Tumor suppressor gene transfer as a therapeutic stratergy for hematopoietic malignancies', in Cancer genetics and tumor supprressor genes conference, Cancer genetics and tumor supprressor genes conference, Frederick, Maryland, pp. 71 - 71, presented at Cancer genetics and tumor supprressor genes conference, Frederick, Maryland, 12 June 1997 - 16 June 1997

Du ZY; Dolnikov A; Rainer SP; Jansz P; Spratt PM; Mundy J; Macdonald PS, 1997, 'Ischemic preconditioning enhances preservation of rat heart during prolonged hypothermic strorage through activation of Katp channels', in Journal of Heart and Lung Transplantation, Elsevier Science Inc, New York, NY, USA, pp. 50, presented at ISHLT: 18th Annual and Scientific meeting of the International Society for Heart and Lung transplant, London, England, 02 April 1997 - 05 April 1997

Dolnikov A; Mackenzie K; Millington M; Yi S; Symonds GP, 1997, 'Tumor suppressor gene transfer as a therapeutic stratergy for hematopoietic malignancies', in Australian Society of Medical research, Australian Society of Medical research, Garvan Institute, Sydney, pp. P-30, presented at Australian Society of Medical research, Garvan Institute, Sydney

School of Women's and Children's Health

Dr Alla Dolnikov

Tabs

Study @ WCH

Research @ WCH

Quick Links

Connect

School of Women's and Children's Health

Dr Alla Dolnikov

Tabs

Publications related to this Person

Book Chapters

Journal articles

Conference Papers

Conference Abstracts

Study @ WCH

Research @ WCH

Quick Links

Connect