Dr Belamy-Bin Cheung

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Contact Category:

Conjoint

Discipline:

Paediatrics

Dr Belamy Cheung, BMed, MSc, PhD

Principal Scientist and Research Manager, Embryonal Cancer Therapy and Prevention
Children’s Cancer Institute Australia
Lowy Cancer Research Centre, University of NSW
PhD Student Supervisor and Senior Lecturer (UNSW)

Dr Belamy Cheung graduated from Sun Yat-Sen University of Medical Science Guangzhou, China in 1983, and obtained her Master and PhD degrees at the Faculty of Medicine, UNSW Sydney in 1994 and 2004, respectively. Currently she is the Principal Scientist and Research Manager at Children's Cancer Institute Australia and a Senior Lecturer at the Faculty of Medicine, UNSW Sydney. Dr Cheung has published 55 original or review articles in the top-ranked journals including Nature Communications, Nature Reviews Cancer, Science Translational Medicine, Oncogene and Cancer Research. Her work has been cited 2062 times, and has an h-index of 27. She has also demonstrated a strong commitment to research supervision and mentoring. Since 2004, she has supervised/mentored 38 Honours, ILP and PhD students in the field of childhood cancer. Dr Cheung directs and drives the research in all three themes in the Embryonal Cancer Therapy and Prevention Group: identification of oncogenic proteins in MYC-driven cancers; developing inhibitors for MYC oncoproteins; and developing childhood cancer prevention strategies.

Contact details:

Dr Belamy Cheung
Children's Cancer Institute Australia.
61 02 9385 2450

bcheung@ccia.unsw.edu.au

School:

Sch Women's&Children's Health

Phone:

(02) 9385 2450

Email:

bcheung@ccia.unsw.edu.au

University role:

Principal Scientist

Qualifications:

Academic and Professional Qualifications:

2004: Doctor of Philosophy, School of Women's and Children's Health, Medicine Faculty, University of New South Wales, Australia. (Awarded on 18/5/2004)
1994: Master of Science, School of Pathology, Medicine Faculty, University of New South Wales, Australia.
1983: Bachelor of Medicine, Sun Yat-Sen University of Medical Science, Guangzhou, P. R. China.

Grants:

Project Grant, the Trustees of the Anthony Rothe Memorial Trust, Application titled “Targeting PA2G4 as a novel treatment strategy for leukaemia and lymphoma" as a Chief Investigator (CI) for two years, $115,000 per annum, 2020–2021.
Project Grant, Kids Cancer Alliance NSW, Application title “Prevention of Child Cancer – Down Syndrome”. Total of $160,000. $ 80,000/year for 2 years from 2018.
NHMRC Project Grant , Application title “Therapeutic targeting of MYCN oncoprotein stability in neuroblastoma”. $590,206.20. from 2017-2019.

UNSW Goldstar Award 2016, APP1101902, Proposal Title: Therapeutic targeting of the MYCN oncogenic signal in childhood neuroblastoma by inhibition of transcriptional elongation complex, FACT”, RG153043, $40,000

Project Grant, CCIA Drug Screening Fund, titled “Identification of novel compounds which enhance the retinoid anti-cancer signal using a high-content TRIM16 translocation assay”. 2012, $10,000

Project Grant, Faculty of Medicine, University of NSW, project title: “Overcoming histone deacetylase inhibitor and retinoid drug resistance through novel combination therapies”, 2011, $11,000

Early Career Development fellowship, ID: 06/ECF/1-04, Cancer Institute New South Wales, 2007-2009, $570, 000

Project grant, Cure Cancer Australia, 2007, $75, 000

Awards:

1. Australia Postgraduate Research Award, 1990-1992
2. Early Career Research Awards, Faculty of Medicine, UNSW, Sydney, 2005
3. Early Career Development fellowship Award, Cancer Institute NSW, 2007
4. The Institute Award for outstanding service, Children’s Cancer Institute Australia, 2010
5. Goldstar Award for a research project, UNSW Sydney, 2016
6. Travel grant, School of Life Sciences and Technology, Shanghai Tongji University, China. 2017.

Research

Research activities:

Current Research Projects:

1. Developing inhibitors for MYC oncoproteins.

2. Identification of co-factors for MYCN oncoprotein.

3. Establishing novel combination therapies of epigenetic drugs for cancer treatment.

4. Developing childhood cancer prevention strategies.

Socio-economic Objective (SEO) tags:

Child Health

Field of Research (FOR) Tag:

Paediatrics

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

ILP, Honours, Masters, PhD

Supervision keywords:

anticancer drugs

nervous system cancers

skin cancer

breast cancer

antineoplastics and immunosuppressives

experimental cancers

Media

Facebook:

https://www.facebook.com/UNSWWomensChildrensHealth/

Publications related to this Person

Journal articles

Stevenson BW; Gorman MA; Koach J; Cheung BB; Marshall GM; Parker MW; Holien JK, 2020, 'A structural view of PA2G4 isoforms with opposing functions in cancer', Journal of Biological Chemistry, vol. 295, pp. 16100 - 16112, http://dx.doi.org/10.1074/jbc.REV120.014293

Tee AE; Ciampa OC; Wong M; Fletcher JI; Kamili A; Chen J; Ho N; Sun Y; Carter DR; Cheung BB; Marshall GM; Liu PY; Liu T, 2020, 'Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN-amplified neuroblastoma', International Journal of Cancer, vol. 147, pp. 1928 - 1938, http://dx.doi.org/10.1002/ijc.32936

Ni J; Cheung BB; Beretov J; Duan W; Bucci J; Malouf D; Graham P; Li Y, 2020, 'CD44 variant 6 is associated with prostate cancer growth and chemo-/radiotherapy response in vivo', Experimental Cell Research, vol. 388, pp. 111850 - 111850, http://dx.doi.org/10.1016/j.yexcr.2020.111850

Bingul M; Arndt GM; Marshall GM; Cheung BB; Kumar N; Black DSC, 2020, 'Synthesis, characterization and biological evaluation of novel dihydropyranoindoles improving the anticancer effects of HDAC inhibitors', Molecules, vol. 25, http://dx.doi.org/10.3390/molecules25061377

Wong M; Sun Y; Xi Z; Milazzo G; Poulos RC; Bartenhagen C; Bell JL; Mayoh C; Ho N; Tee AE; Chen X; Li Y; Ciaccio R; Liu PY; Jiang CC; Lan Q; Jayatilleke N; Cheung BB; Haber M; Norris MD; Zhang XD; Marshall GM; Wang JY; Hüttelmaier S; Fischer M; Wong JWH; Xu H; Perini G; Dong Q; George RE; Liu T, 2019, 'JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma', Nature Communications, vol. 10, pp. 3319, http://dx.doi.org/10.1038/s41467-019-11132-w

Liu PY; Tee AE; Milazzo G; Hannan KM; Maag J; Mondal S; Atmadibrata B; Bartonicek N; Peng H; Ho N; Mayoh C; Ciaccio R; Sun Y; Henderson MJ; Gao J; Everaert C; Hulme AJ; Wong M; Lan Q; Cheung BB; Shi L; Wang JY; Simon T; Fischer M; Zhang XD; Marshall GM; Norris MD; Haber M; Vandesompele J; Li J; Mestdagh P; Hannan RD; Dinger ME; Perini G; Liu T, 2019, 'The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35', Nature Communications, vol. 10, pp. 5026, http://dx.doi.org/10.1038/s41467-019-12971-3

Koach J; Holien JK; Massudi H; Carter DR; Ciampa OC; Herath M; Lim T; Seneviratne JA; Milazzo G; Murray JE; McCarroll JA; Liu B; Mayoh C; Keenan B; Stevenson BW; Gorman MA; Bell JL; Doughty L; Hüttelmaier S; Oberthuer A; Fischer M; Gifford AJ; Liu T; Zhang X; Zhu S; Gustafson WC; Haber M; Norris MD; Fletcher JI; Perini G; Parker MW; Cheung BB; Marshall GM, 2019, 'Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface', Cancer Research, vol. 79, pp. 5652 - 5667, http://dx.doi.org/10.1158/0008-5472.CAN-19-1112

Sutton SK; Cheung BB; Massudi H; Tan O; Koach J; Mayoh C; Carter DR; Marshall GM, 2019, 'Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis', Journal of Cancer Research and Clinical Oncology, vol. 145, pp. 2241 - 2250, http://dx.doi.org/10.1007/s00432-019-02981-5

Gamble LD; Purgato S; Murray J; Xiao L; Yu DMT; Hanssen KM; Giorgi FM; Carter DR; Gifford AJ; Valli E; Milazzo G; Kamili A; Mayoh C; Liu B; Eden G; Sarraf S; Allan S; Giacomo SD; Flemming CL; Russell AJ; Cheung BB; Oberthuer A; London WB; Fischer M; Trahair TN; Fletcher JI; Marshall GM; Ziegler DS; Hogarty MD; Burns MR; Perini G; Norris MD; Haber M, 2019, 'Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma', Science Translational Medicine, vol. 11, http://dx.doi.org/10.1126/scitranslmed.aau1099

Hu X; Zheng W; Zhu Q; Gu L; Du Y; Han Z; Zhang X; Carter DR; Cheung BB; Qiu A; Jiang C, 2019, 'Increase in DNA damage by MYCN knockdown through regulating nucleosome organization and chromatin state in neuroblastoma', Frontiers in Genetics, vol. 10, http://dx.doi.org/10.3389/fgene.2019.00684

Ooi CY; Carter DR; Liu B; Mayoh C; Beckers A; Lalwani A; Nagy Z; De Brouwer S; Decaesteker B; Hung TT; Norris MD; Haber M; Liu T; De Preter K; Speleman F; Cheung BB; Marshall GM, 2018, 'Network modeling of microRNA-mRNA interactions in neuroblastoma tumorigenesis identifies miR-204 as a direct inhibitor of MYCN', Cancer Research, vol. 78, pp. 3122 - 3134, http://dx.doi.org/10.1158/0008-5472.CAN-17-3034

Tang Y; Cheung BB; Atmadibrata B; Marshall GM; Dinger ME; Liu PY; Liu T, 2017, 'The regulatory role of long noncoding RNAs in cancer', Cancer Letters, vol. 391, pp. 12 - 19, http://dx.doi.org/10.1016/j.canlet.2017.01.010

Sutton SK; Carter DR; Kim P; Tan O; Arndt GM; Zhang XD; Baell J; Noll BD; Wang S; Kumar N; McArthur GA; Cheung BB; Marshall GM, 2016, 'A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner', Oncotarget, vol. 7, pp. 52166 - 52178, http://dx.doi.org/10.18632/oncotarget.10700

Bingul M; Tan O; Gardner CR; Sutton SK; Arndt GM; Marshall GM; Cheung BB; Kumar N; Black DSC, 2016, 'Synthesis, characterization and anti-cancer activity of hydrazide derivatives incorporating a quinoline moiety', Molecules, vol. 21, http://dx.doi.org/10.3390/molecules21070916

Carter DR; Sutton SK; Pajic M; Murray J; Sekyere EO; Fletcher J; Beckers A; De Preter K; Speleman F; George RE; Haber M; Norris MD; Cheung BB; Marshall GM, 2016, 'Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis', Molecular Oncology, vol. 10, pp. 866 - 878, http://dx.doi.org/10.1016/j.molonc.2016.02.004

Kim PY; Tan O; Liu B; Trahair T; Liu T; Haber M; Norris MD; Marshall GM; Cheung BB, 2016, 'High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients', Cancer Letters, vol. 374, pp. 315 - 323, http://dx.doi.org/10.1016/j.canlet.2016.02.021

Tee AE; Liu B; Song R; Li J; Pasquier E; Cheung BB; Jiang C; Marshall GM; Haber M; Norris MD; Fletcher JI; Dinger ME; Liu T, 2016, 'The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression', Oncotarget, vol. 7, pp. 8663 - 8675, http://dx.doi.org/10.18632/oncotarget.6675

Xue C; Yu DMT; Gherardi S; Koach J; Milazzo G; Gamble L; Liu B; Valli E; Russell AJ; London WB; Liu T; Cheung BB; Marshall GM; Perini G; Haber M; Norris MD, 2016, 'MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4', Oncotarget, vol. 7, pp. 54937 - 54951, http://dx.doi.org/10.18632/oncotarget.10709

Fabian J; Opitz D; Althoff K; Lodrini M; Hero B; Volland R; Beckers A; Preter KD; Decock A; Patil N; Abba M; Kopp-Schneider A; Astrahantseff K; Wünschel J; Pfeil S; Ercu M; Künkele A; Hu J; Thole T; Schweizer L; Mechtersheimer G; Carter D; Cheung BB; Popanda O; Deimling AV; Koster J; Versteeg R; Schwab M; Marshall GM; Speleman F; Erb U; Zoeller M; Allgayer H; Simon T; Fischer M; Kulozik AE; Eggert A; Witt O; Schulte JH; Deubzer HE, 2016, 'MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma', Oncotarget, vol. 7, pp. 66344 - 66359, http://dx.doi.org/10.18632/oncotarget.11662

Liu PY; Sokolowski N; Guo ST; Siddiqi F; Atmadibrata B; Telfer TJ; Sun Y; Zhang L; Yu D; Mccarroll J; Liu B; Yang RH; Guo XY; Tee AE; Itoh K; Wang J; Kavallaris M; Haber M; Norris MD; Cheung BB; Byrne JA; Ziegler DS; Marshall GM; Dinger ME; Codd R; Zhang XD; Liu T, 2016, 'The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs', Oncotarget, vol. 7, pp. 79217 - 79232, http://dx.doi.org/10.18632/oncotarget.12640

Cheung BB, 2015, 'Combination therapies improve the anticancer activities of retinoids in neuroblastoma', World Journal of Clinical Oncology, vol. 6, pp. 212 - 215, http://dx.doi.org/10.5306/wjco.v6.i6.212

Beckers A; Van Peer G; Carter DR; Gartlgruber M; Herrmann C; Agarwal S; Helsmoortel HH; Althoff K; Molenaar JJ; Cheung BB; Schulte JH; Benoit Y; Shohet JM; Westermann F; Marshall GM; Vandesompele J; De Preter K; Speleman F, 2015, 'MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma', Cancer Letters, vol. 366, pp. 123 - 132, http://dx.doi.org/10.1016/j.canlet.2015.06.015

Cheung BB; Tan O; Koach J; Liu B; Shum MSY; Carter DR; Sutton S; Po'uha ST; Chesler L; Haber M; Norris MD; Kavallaris M; Liu T; O'Neill GM; Marshall GM, 2015, 'Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma', Molecular Oncology, vol. 9, pp. 1484 - 1500, http://dx.doi.org/10.1016/j.molonc.2015.04.005

Lambertz I; Kumps C; Claeys S; Lindner S; Beckers A; Janssens E; Carter DR; Cazes A; Cheung BB; De Mariano M; De Bondt A; De Brouwer S; Delattre O; Gibbons J; Janoueix-Lerosey I; Laureys G; Liang C; Marchall GM; Porcu M; Takita J; Trujillo DC; Van Den Wyngaert I; Van Roy N; Van Goethem A; Van Maerken T; Zabrocki P; Cools J; Schulte JH; Vialard J; Speleman F; De Preter K, 2015, 'Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma: Implications for targeted treatment', Clinical Cancer Research, vol. 21, pp. 3327 - 3339, http://dx.doi.org/10.1158/1078-0432.CCR-14-2024

Beckers A; Peer GV; Carter DR; Mets E; Althoff K; Cheung BB; Schulte JH; Mestdagh P; Vandesompele J; Marshall GM; De Preter KD; Speleman F, 2015, 'MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation', Oncotarget, vol. 6, pp. 5204 - 5216, http://dx.doi.org/10.18632/oncotarget.2477

Carter DR; Murray J; Cheung BB; Gamble L; Koach J; Tsang J; Sutton S; Kalla H; Syed S; Gifford AJ; Issaeva N; Biktasova A; Atmadibrata B; Sun Y; Sokolowski N; Ling D; Kim PY; Webber H; Clark A; Ruhle M; Liu B; Oberthuer A; Fischer M; Byrne J; Saletta F; Thwe LM; Purmal A; Haderski G; Burkhart C; Speleman F; De Preter K; Beckers A; Ziegler DS; Liu T; Gurova KV; Gudkov AV; Norris MD; Haber M; Marshall GM, 2015, 'Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma', Science Translational Medicine, vol. 7, http://dx.doi.org/10.1126/scitranslmed.aab1803

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2015, 'Erratum: Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression (Journal of the National Cancer Institute (2014) 106:7 (dju113) DOI: 10.1093/jnci/dju113)', Journal of the National Cancer Institute, vol. 107, http://dx.doi.org/10.1093/jnci/dju359

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2014, 'Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression', Journal of the National Cancer Institute, vol. 106, http://dx.doi.org/10.1093/jnci/dju113

Tee EL; Ling D; Nelson C; Atmadibrata B; Dinger M; XU N; Mizukami T; Liu PY; Liu B; Cheung B; Pasquier E; Haber M; Norris MD; Suzuki T; Marshall GM; Liu T, 2014, 'The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1', Oncotarget, vol. 5, pp. 1793 - 1804, http://dx.doi.org/10.18632/oncotarget.1785

Kim PY; Tan O; Diakiw SM; Carter D; Sekerye EO; Wasinger VC; Liu T; Kavallaris M; Norris MD; Haber M; Chesler L; Dolnikov A; Trahair TN; Cheung NK; Marshall GM; Cheung BB, 2014, 'Identification of plasma Complement C3 as a potential biomarker for neuroblastoma using a quantitative proteomic approach', Journal of Proteomics, vol. 96, pp. 1 - 12, http://dx.doi.org/10.1016/j.jprot.2013.10.032

Marshall GM; Carter DR; Cheung BB; Liu T; Mateos MK; Meyerowitz JG; Weiss WA, 2014, 'The prenatal origins of cancer', Nature Reviews Cancer, vol. 14, pp. 277 - 289, http://dx.doi.org/10.1038/nrc3679

Sutton SK; Koach J; Tan O; Liu B; Carter DR; Wilmott JS; Yosufi B; Haydu LE; Mann GJ; Thompson JF; Long GV; Liu T; McArthur G; Zhang XD; Scolyer RA; Cheung BB; Marshall GM, 2014, 'TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells', Oncotarget, vol. 5, pp. 10127 - 10139, http://dx.doi.org/10.18632/oncotarget.2466

Bingul M; Cheung BB; Kumar N; Black DSC, 2014, 'Synthesis of symmetrical and unsymmetrical diindolylmethanes via acid-catalysed electrophilic substitution reactions', Tetrahedron, vol. 70, pp. 7363 - 7369, http://dx.doi.org/10.1016/j.tet.2014.06.087

Liu PY; Xu N; Malyukova A; Scarlett CJ; Sun YT; Zhang XD; Ling D; Su SP; Nelson CA; Chang DK; Koach J; Tee AE; Haber M; Norris MD; Rooman I; Toon C; Xue C; Cheung B; Kumar S; Marshall GM; Biankin AV; Liu T, 2013, 'The histone deacetylase SIRT2 stabilizes Myc oncoproteins', Cell Death and Differentiation, vol. 20, pp. 503 - 514, http://dx.doi.org/10.1038/cdd.2012.147

Sekyere E; Thomas WD; Keating J; Calao M; Cui HJ; Chen JB; Raif A; Jankowski K; Cheung B; Davies NP NP; Trahair TN; Liu T; Wainwright BJ; Ding HF; Marshall GM, 2013, 'Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation', Oncogene, vol. 32, pp. 3616 - 3626, http://dx.doi.org/10.1038/onc.2012.368

Bell JL; Malyukova A; Kavallaris M; Marshall GM; Cheung BB, 2013, 'TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization', Cell Cycle, vol. 12, pp. 889 - 898, http://dx.doi.org/10.4161/cc.23825

Kim PY; Rahmanto AS; Tan O; Norris MD; Haber M; Marshall GM; Cheung BB, 2013, 'TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells', Apoptosis, vol. 18, pp. 639 - 651, http://dx.doi.org/10.1007/s10495-013-0813-y

Cheung BB; Koach J; Tan O; Kim P; Bell J; D'andreti C; Sutton S; Malyukova A; Sekyere E; Norris MD; Haber M; Kavallaris M; Cunningham AM; Proby C; Leigh I; Wilmott J; Cooper C; Halliday GM; Scolyer RA; Marshall GM, 2012, 'The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro', Journal of Pathology, vol. 226, pp. 451 - 462, http://dx.doi.org/10.1002/path.2986

Bell J; Malyukova A; Holien J; Koach J; Parker M; Kavallaris M; Marshall GM; Cheung BB, 2012, 'TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members', PLoS One, vol. 7, pp. Article number e37470, http://dx.doi.org/10.1371/journal.pone.0037470

Gardner C; Cheung BB; Koach J; Black D; Marshall GM; Kumar NSS, 2012, 'Synthesis of retinoid enhancers based on 2-aminobenzothiazoles for anti-cancer therapy', Bioorganic and Medicinal Chemistry, vol. 20, pp. 6877 - 6884, http://dx.doi.org/10.1016/j.bmc.2012.09.035

Cheung BB; Marshall GM, 2011, 'Targeting ATP7A to increase the sensitivity of neuroblastoma cells to retinoid therapy', Current Cancer Drug Targets, vol. 11, pp. 826 - 836, http://dx.doi.org/10.2174/156800911796798968

Liu T, 2010, 'TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells', Oncogene, vol. 29, pp. 6172 - 6183, http://dx.doi.org/10.1038/onc.2010.340

Raif A; Marshall GM; Bell J; Koach J; Tan O; D'andreti C; Thomas WD; Sekyere E; Norris MD; Haber M; Kavallaris M; Cheung BB, 2009, 'The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation', Cancer Letters, vol. 277, pp. 82 - 90, http://dx.doi.org/10.1016/j.canlet.2008.11.030

Thomas WD; Chen J; Gao YR; Cheung BB; Koach J; Sekyere E; Norris MD; Haber M; Ellis T; Wainwright B; Marshall GM, 2009, 'Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression', Oncogene, vol. 28, pp. 1605 - 1615, http://dx.doi.org/10.1038/onc.2009.3

Bohlken A; Cheung B; Bell J; Koach J; Smith S; Sekyere E; Thomas WD; Norris MD; Haber M; Lovejoy DB; Richardson DR; Marshall GM, 2009, 'ATP7A is a novel target of retinoic acid receptor beta(2) in neuroblastoma cells', British Journal of Cancer, vol. 100, pp. 96 - 105, http://dx.doi.org/10.1038/sj.bjc.6604833

Cheung BB; Bell J; Raif A; Bohlken A; Yan J; Poljak A; Smith S; Lee M; Thomas WD; Kavallaris M; Norris MD; Haber M; Liu H; Zajchowski D; Marshall GM; bell , 2006, 'The estrogen-responsive B box protein is a novel regulator of the retinoid signal', The Journal of Biological Chemistry, vol. 281, pp. 18246 - 18256, http://dx.doi.org/10.1074/jbc.M600879200

Liu T, 2005, 'The retinoid anticancer signal: mechanisms of target gene regulation', British Journal of Cancer, vol. 93, pp. 310 - 318, http://dx.doi.org/10.1038/sj.bjc.6602700

Cheung BB; Yan JX; Smith SA; Nguyen TG; Lee M; Kavallaris M; Norris MD; Haber M; Marshall GM, 2003, 'Growth inhibitory retinoid effects after recruitment of retinoid X receptor B to the retinoic acid receptor B promoter', International Journal of Cancer, vol. 105, pp. 856 - 867, http://dx.doi.org/10.1002/ijc.11153

Hansford LM; Smith S; Haber M; Norris MD; Cheung BB; Marshall GM, 2003, 'Cloning and characterisation of the human neural cell adhesion molecule, (CNTN4) ( alias BIG-2)', Cytogenetic and Genome Research, vol. 101, pp. 1 - 17, http://dx.doi.org/10.1159/000073412

Nguyen TG; Hocker JE; Thomas WD; Smith SA; Norris MD; Haber M; Cheung BB; Marshall GM, 2003, 'Combined RAR and RXr-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells', Biochemical and Biophysical Research Communications, vol. 302, pp. 462 - 468, http://dx.doi.org/10.1016/S0006-291X(03)00177-3

Kavallaris M; Gardaneh M; Cheung BB; Camacho M; Hocker JE; Norris MD; Haber M; Marshall GM, 1998, 'In Vitro effects of MYCN sense and antisense expression in MYCN-amplified human neuroblastoma cells', Anticancer Research, vol. 18, pp. 1793 - 1798

Cheung BB; Hocker JE; Smith S; Norris MD; Haber M; Marshall GM, 1998, 'Favorable prognostic signifiance of high-level retinoic acid receptor B expression in neuroblastoma mediated by effects on cell cycle regulation', Oncogene, vol. 17, pp. 751 - 759, http://dx.doi.org/10.1038/sj.onc.1201982

Cheung BB; Hocker JE; Smith SA; Reichert U; Norris MD; Haber M; Stewart BW; Marshall GM, 1996, 'Retinoic acid receptors B and g distinguish retinoid signals for growth inhibition and neuritogenesis in human neuroblastoma cells', Biochemical and Biophysical Research Communications, vol. 229, pp. 349 - 354, http://dx.doi.org/10.1006/bbrc.1996.1804

Marshall GM; Cheung BB; Stacey KP; Camacho M; Simpson AM; Kwan EN; Smith S; Haber M; Norris MD, 1995, 'Increased retinoic acid receptor gamma expression suppresses the malignant phenotype and alters the differentiation potential of human neuroblastoma cells', Oncogene, vol. 11, pp. 485 - 491

Bordow SB; Haber M; Madaflglio J; Cheung B; Marshall GM; Norris MD, 1994, 'Expression of the Multidrug Resistance-associated Protein (MRP) Gene Correlates with Amplification and Overexpression of the N-myc Oncogene in Childhood Neuroblastoma', Cancer Research, vol. 54, pp. 5036 - 5040

MARSHALL GM; CHEUNG B; STACEY KP; NORRIS MD; HABER M, 1994, 'REGULATION OF RETINOIC ACID RECEPTOR-ALPHA EXPRESSION IN HUMAN NEUROBLASTOMA CELL-LINES AND TUMOR-TISSUE', ANTICANCER RESEARCH, vol. 14, pp. 437 - 441, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994NR46300017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Haber M; Madafiglio J; Bordow SB; Gilbert J; Cheung B; Marshall GM; Norris MD, 1994, 'Expression of retinoic acid-responsive genes in primary neuroblastomas.', Progress in clinical and biological research, vol. 385, pp. 245 - 251

Marshall GM; Cheung B; Stacey KP; Norris MD; Haber M, 1994, 'Regulation of retinoic acid receptor alpha expression in human neuroblastoma cell lines and tumor tissue', Anticancer Research, vol. 14, pp. 437 - 441

Conference Papers

Cheung BB; Sutton SK; Tan O; Koach J; Liu B; Liu T; Scolyer RA; Zhang XD; Marshall GM, 2013, 'TRIM16 is a prognostic marker for patients with lymph node metastatic melanoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Washington, DC, presented at 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC, 06 April 2013 - 10 April 2013, http://dx.doi.org/10.1158/1538-7445.AM2013-3876

Thomas W; Chen J; Gao Y; Koach J; Cheung B; Ellis T; Norris M; Haber M; Wainwright B; Marshall G, 2008, 'STABILIZATION OF THE MYCN ONCOPROTEIN AS A MECHANISM OF INITIATION AND PROGRESSION IN MEDULLOBLASTOMA RESULTING FROM SONIC HEDGEHOG PATHWAY ACTIVATION', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Las Vegas, NV, pp. 870 - 870, presented at 13th Annual Meeting of the Society-for-Neuro-Oncology (SNO), Las Vegas, NV, 20 November 2008 - 23 November 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000259854500409&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bell JL; Cheung BB; D'Andreti C; Koach J; Raif A; Thomas WD; Norris M; Haber M; Kavallaris M; Marshall GM, 2008, 'The role of the estrogen-responsive B box protein (EBBP) in cancer cell cycle progression', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Lyon, FRANCE, pp. 95 - 95, presented at 20th Meeting of the European-Association-for-Cancer-Research, Lyon, FRANCE, 05 July 2008 - 08 July 2008, http://dx.doi.org/10.1016/S1359-6349(08)71542-8

Thomas WD; Keating J; Cheung B; Armatai P; Weiss W; Norris M; Haber M; Marshall GM, 2006, 'Neuroblastoma tumor initiation: MYCN mediated mechanisms of resistance to cell death', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606201380&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cheung BB; Bell J; Raif A; Yan J; Roediger B; Smith S; Lee M; Thomas WD; Kavallaris M; Norris M; Haber M; Liu H-L; Zajchowski D; Marshall GM, 2006, 'Characterization of a novel regulator of the retinoid signal: The estrogen-responsive B box protein.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454608804357&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Yuan X; Du S; Seneviratne J; Xu Y; Cheung B; Marshall G; Carter D; Zhang C, 2019, 'Single-Cell RNA-SEQ Identifies that Adrenergic Neuroblasts Possess a BI-FATE Differentiation Potential in Peripheral Neuroblastictumors', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 66, pp. S345 - S346, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488458004050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Deubzer H; Fabian J; Opitz D; Althoff K; Lodrini M; Astrahantseff K; Hero B; Volland R; Beckers A; De Preter K; Patil N; Abba M; Wuenchel J; Thole T; Hu J; Schweitzer L; Mechtersheimer G; Carter D; Cheung B; Popanda O; von Deimling A; Henrich KO; Westermann F; Schwab M; Koster J; Versteeg R; Marshall G; Speleman F; Zoeller M; Allgayer H; Fischer M; Berthold F; Kulozik A; Witt O; Schulte J; Eggert A, 2015, 'MYCN TRANSCRIPTIONALLY REPRESSES CD9 TO TRIGGER AN INVASION-METASTASIS CASCADE IN NEUROBLASTOMA', in PEDIATRIC BLOOD & CANCER, WILEY-BLACKWELL, Vol. 62, pp. S150 - S150, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361247200022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

School of Women's and Children's Health

Dr Belamy-Bin Cheung

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