Dr Duohui Jing

Tabs

Main

Contact Category:

Conjoint

Discipline:

Paediatrics

Dr Duohui Jing graduated from Tsinghua University, China in 2004, and undertook doctoral study on Internal Medicine at Technische Universität Dresden, Germany. In 2011, he relocated from Germany to Australia and started his research on molecular mechanisms of chemo-resistance in acute lymphoblastic leukaemia (ALL). He has established several cutting-edge techniques such as ChIP-seq, ATAC-seq, CRISPR/Cas9, 3C/HiC and more, in ALL patient-derived xenografts. This led to the development of a novel platform that integrated multiple whole-genome approaches with glucocorticoid-based chemotherapy (Blood, first author, 2015; Cancer Cell, first & co-corresponding author, 2018). His work has been featured as the cover story of Cancer Cell and the subject of commentaries in Blood and Cancer Cell, which indicates a substantial recognition in the field. Furthermore, Dr Jing has established an ex vivo co-culture system for maintaining human primary hematopoietic stem cells (Haematologica, first author, 2010 & 2012), and provided technical support for assessing drug efficacy in vivo using bioluminescence imaging (Clin Cancer Res 2017) and single cell profiling (Cancer Cell 2019). His publications have received >900 citations at an average of over 50/article. Over the past 5 years (2015-2019), Dr Jing, as Chief Investigator A, has been awarded 6 grants of a total $1.66M in Australia, including the Australia National Health and Medical Research Council (NHMRC) Idea Grant and Cancer Institute NSW Early Career Fellowship.

School:

Sch Women's&Children's Health

Email:

jdh12262@rjh.com.cn

University role:

Conjoint Senior Lecturer

Qualifications:

08/2010, Doctor rerum Medicinalium, Internal Medicine, Technische Universität Dresden, Germany

08/2006, Master of Science, Molecular Bioengineering, Technische Universität Dresden, Germany

08/2004 , Bachelor of Science, Biological Science, Tsinghua University, China

Awards:

2019 UNSW publication award (Promoting High Quality Research Papers Scheme – Key Incentive 1)

2018 Research Excellence Award, Australian Association for Chinese Biomedical Scientists, October

2017 Service Excellence Award, Australian Association for Chinese Biomedical Scientists, November

2016 Balnaves Foundation and Children’s Cancer Institute Travel Grant

2016 Roche New Investigator Travel Grant, at the New Directions in Leukaemia Research Conference, Noosa, March

2015 Illumina Early Career Researcher Speaker Awards – second place, at Epigenetics Conference, Hobart, November

Research

Field of Research (FOR) Tag:

Paediatrics

Cancer Cell Biology

Haematological Tumours

Haematology

Teaching & Supervision

Areas of supervision:

Media

LinkedIn:

http://au.linkedin.com/in/duohuijing

Publications related to this Person

Journal articles

Jing D; Bhadri VA; Beck D; Thoms JAI; Yakob NA; Wong JWH; Knezevic K; Pimanda JE; Lock RB, 2015, 'Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells', Blood, vol. 125, pp. 273 - 283, http://dx.doi.org/10.1182/blood-2014-05-576470

Jamieson SMF; Gu Y; Manesh DM; El-Hoss J; Jing D; Mackenzie KL; Guise CP; Foehrenbacher A; Pullen SM; Benito J, 2014, 'A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells', Biochemical Pharmacology, vol. 88, pp. 36 - 45, http://dx.doi.org/10.1016/j.bcp.2013.12.019

Jing D; Wobus M; Poitz DM; Bornhäuser M; Ehninger G; Ordemann R, 2012, 'Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro', Haematologica, vol. 97, pp. 331 - 339, http://dx.doi.org/10.3324/haematol.2011.050815

Jing R, 2012, 'Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro', Haematologica, vol. 97, pp. 331 - 339, http://www.scopus.com/inward/record.url?eid=2-s2.0-84857707368&partnerID=40&md5=9598a81796d65821a6301e02c766cd27

Jing D; Fonseca AV; Alakel N; Fierro FA; Muller K; Bornhauser M; Ehninger G; Corbeil D; Ordemann R, 2010, 'Hematopoietic stem cells in co-culture with mesenchymal stromal cells -modeling the niche compartments in vitro', Haematologica, vol. 95, pp. 542 - 550, http://dx.doi.org/10.3324/haematol.2009.010736

Jing D; Oelschlaegel U; Ordemann R; Hölig K; Ehninger G; Reichmann H; Ziemssen T; Bornhäuser M, 2010, 'CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function', Bone Marrow Transplantation, vol. 45, pp. 1489 - 1496, http://dx.doi.org/10.1038/bmt.2009.381

Jing D; Alakel N; Bornhäuser M; Ehninger G; Ordemann R, 2010, 'SDF-1/CXCR4 blockade to mobilize hematopoietic progenitor cells from the placenta', Bone Marrow Transplantation, vol. 45, pp. 1661 - 1662, http://dx.doi.org/10.1038/bmt.2010.22

Jing R, 2010, 'Hematopoietic stem cells in co-culture with mesenchymal stromal cells -modeling the niche compartments in vitro', Haematologica, vol. 95, pp. 542 - 550, http://www.scopus.com/inward/record.url?eid=2-s2.0-77950639113&partnerID=40&md5=b8af85bbecb1fcdc633fff4b801438ce

Jing M, 2010, 'CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function', Bone Marrow Transplantation, vol. 45, pp. 1489 - 1496, http://www.scopus.com/inward/record.url?eid=2-s2.0-77957947043&partnerID=40&md5=f17d4c8800fec7cbf55a65cde0e9ebc7

Jing R, 2010, 'SDF-1/CXCR4 blockade to mobilize hematopoietic progenitor cells from the placenta', Bone Marrow Transplantation, vol. 45, pp. 1661 - 1662, http://www.scopus.com/inward/record.url?eid=2-s2.0-78149465286&partnerID=40&md5=2d6f880997130dbcecb201845bb34aad

Seib FP; Franke M; Jing D; Werner C; Bornhäuser M, 2009, 'Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells', European Journal of Cell Biology, vol. 88, pp. 257 - 271, http://dx.doi.org/10.1016/j.ejcb.2009.01.003

Alakel N; Jing D; Muller K; Bornhauser M; Ehninger G; Ordemann R, 2009, 'Direct contact with mesenchymal stromal cells affects migratory behavior and gene expression profile of CD133⁺ hematopoietic stem cells during ex vivo expansion', Experimental Hematology, vol. 37, pp. 504 - 513, http://dx.doi.org/10.1016/j.exphem.2008.12.005

Alakel R, 2009, 'Direct contact with mesenchymal stromal cells affects migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex vivo expansion', Experimental Hematology, vol. 37, pp. 504 - 513, http://www.scopus.com/inward/record.url?eid=2-s2.0-62149144443&partnerID=40&md5=edc533e2c6d48d5c6b034d78498addc4

Seib M, 2009, 'Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells', European Journal of Cell Biology, vol. 88, pp. 257 - 271, http://www.scopus.com/inward/record.url?eid=2-s2.0-62649173542&partnerID=40&md5=312e598afe98bb24adf2af3f5eb39b31

Fierro F; Illmer T; Jing D; Schleyer E; Ehninger G; Boxberger S; Bornhäuser M, 2007, 'Inhibition of platelet-derived growth factor receptorβ by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitro', Cell Proliferation, vol. 40, pp. 355 - 366, http://dx.doi.org/10.1111/j.1365-2184.2007.00438.x

Fierro M, 2007, 'Inhibition of platelet-derived growth factor receptorβ by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitro', Cell Proliferation, vol. 40, pp. 355 - 366, http://www.scopus.com/inward/record.url?eid=2-s2.0-34249025381&partnerID=40&md5=e85212fd34bb2f9a462cdea0c9ba016a

Cao W; Wang A; Jing D; Gong Y; Zhao N; Zhang X, 2005, 'Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)', Journal of Biomaterials Science, Polymer Edition, vol. 16, pp. 1379 - 1394, http://dx.doi.org/10.1163/156856205774472308

Cao W; Jing D; Li J; Gong Y; Zhao N; Zhang X, 2005, 'Effects of the degree of deacetylation on the physicochemical properties and Schwann cell affinity of chitosan films', Journal of Biomaterials Applications, vol. 20, pp. 157 - 177, http://dx.doi.org/10.1177/0885328205049897

Cao X, 2005, 'Influence of irradiation sterilization on mechanical properties and biodegradability of chitosan conduits', He Jishu/Nuclear Techniques, vol. 28, pp. 187 - 191, http://www.scopus.com/inward/record.url?eid=2-s2.0-16644369194&partnerID=40&md5=4529c1267efaba1ec2e3f61cbf059fbb

Cao X, 2005, 'Effects of the degree of deacetylation on the physicochemical properties and Schwann cell affinity of chitosan films', Journal of Biomaterials Applications, vol. 20, pp. 157 - 177, http://www.scopus.com/inward/record.url?eid=2-s2.0-27144549738&partnerID=40&md5=7786d8d7640840521138af5389ce2d5d

Cao X, 2005, 'Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)', Journal of Biomaterials Science, Polymer Edition, vol. 16, pp. 1379 - 1394, http://www.scopus.com/inward/record.url?eid=2-s2.0-33644824069&partnerID=40&md5=6f9ad88290668401813de4fd36e02173

Conference Papers

Lock RB; Toscan CE; Jing D; Mayoh C, 2019, 'Reversal of glucocorticoid resistance in pediatric acute lymphoblastic leukemia is dependent on restoring BIM expression', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1535-7163.TARG-19-A123

Jing D; Huang Y; Liu X; Sia K; Poulos RC; Span M; Zhang C; Mi J; Wong JWH; Beck D, 2018, 'Lymphocyte-specific chromatin accessibility predetermines glucocorticoid resistance in acute lymphoblastic leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Chicago, IL, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, 14 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-3173

Cao WL; Jing DH; Gong YD; Zhao NM; Zhang XF, 2004, 'Surface crosslinked chitosan tube with HDI: A promising guide for peripheral nerve regeneration', in Transactions - 7th World Biomaterials Congress, pp. 1562

Cao XF, 2004, 'Surface crosslinked chitosan tube with HDI: A promising guide for peripheral nerve regeneration', pp. 1562 - 1562, http://www.scopus.com/inward/record.url?eid=2-s2.0-13844271996&partnerID=40&md5=dbce102334e84cb16fa361362f361473

Other

Horton T, 2015, Yin and yang of glucocorticoid receptors in apoptosis, American Society of Hematology, http://dx.doi.org/10.1182/blood-2014-11-609206

School of Women's and Children's Health

Dr Duohui Jing

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