Dr Toby Trahair

Tabs

Main

Contact Category:

Conjoint

Discipline:

Paediatrics

Dr Toby Trahair is a Conjoint Lecturer in the School of Women’s & Children’s Health, Faculty of Medicine, UNSW. He has appointments as a staff specialist in paediatric haematology and oncology at the Kids Cancer Centre, Sydney Children’s Hospital and a Clinical Research Fellow at the Children’s Cancer Institute.

Dr Toby Trahair is a paediatric haematologist & oncologist who has practiced as a Staff Specialist at the Kids Cancer Centre since 2006. In addition, Toby is a clinical research fellow at Children's Cancer Institute with 15 years of postdoctoral experience, commencing with a post-doctoral fellowship at the Stem Cell Research Laboratory, Peter MacCallum Cancer Centre before moving to CCI in 2006.

Toby is involved in clinical trials research as the lead Australian investigator on the international SIOPEN trial for high risk neuroblastoma and an investigator on the early phase I/II Ceritinib trial for children and teenagers with ALK-rearranged malignancies. Dr Trahair has served as executive treasurer on the Executive Council of the Australian and New Zealand Children's Haematology and Oncology Group (ANZCHOG) since 2010.

Toby has active research interests in the management of acute lymphoblastic leukaemia including techniques of minimal residual disease detection, mechanisms and models of drug resistance in ALL, haematopoietic stem cell transplantation, ALK rearranged tumours and personalised therapy for high risk tumours. He currently supervises PhD students, the ERASE project which is identifying clinical and genetic risk factors for treatment-related side effects in ALL patients.

Current research projects include:

Predictive clinical and genetic factors for the side effects of chemotherapy in children treated for acute lymphoblastic leukaemia (The ERASE and ASSET projects). A collaborative project with Prof G Marshall, Dr L Dalla-Pozza & Dr Marion Mateos. A project funded by the Kids Cancer Alliance and supported by the Australian and New Zealand Children’s Haematology & Oncology Group.
Finding new treatments for ALK+ve inflammatory myofibroblastic tumours. A collaborative project with Dr Karen MacKenzie at the Children’s Cancer Institute. A project supported by the Rory Williams Fund.
Developing xenograft models of high risk neuroblastoma. A project in collaboration with Dr Jamie Fletcher, Children’s Cancer Institute and funded by the Kids Cancer Alliance.

School:

Sch Women's&Children's Health

Phone:

+612 9382 2970

Email:

Toby.Trahair@health.nsw.gov.au

University role:

Conjoint Lecturer

Qualifications:

BSc(Med) Hons I MBBS Hons I PhD FRACP

Grants:

Grants & Fellowship Support

2005 National Health and Medical Research Council Australian Biomedical (Peter Doherty) Training Fellowship, “Ex vivo expansion of human umbilical cord blood stem and progenitor cells”, Amount awarded $264,000
2007 Sylvia and Charles Viertel Charitable Foundation Clinical Investigatorship, “Differentiation trapping to identify mutations in cellular genes which contribute to the development of the children’s cancer neuroblastoma”. Amount awarded $60,000
2007 Clive and Vera Ramciotti Foundation Establishment Gift, “Identification of mutations in cellular genes which contribute to the development of neuroblastoma using retroviral gene trap mutagenesis in mouse embryonic stem cells”. Amount awarded $30,000
2007 Cancer Institute NSW Clinical Research Fellowship, “Gene trapping to identify mutations in cellular genes which contribute to the development of embryonal cancers in children”. Amount awarded $323,289
2007 Sydney Children’s Hospital Foundation Grant, “Gene trap mutagenesis to identify mutations in cellular genes which contribute to the development of acute lymphoblastic leukaemia”. Amount awarded $50,000
2012 Kids Cancer Alliance. Project Grant “Predictive clinical and genetic risk factors for the side-effects of chemotherapy in children treated for acute lymphoblastic leukaermia”. Amount awarded $380,000. Role: Chief Investigator A
2014 Kids Cancer Alliance. Project Grant “Establishment of patient-derived xenograft (PDX) models for high risk neuroblastoma” Amount Awarded: $300,000. Role Chief Investigator B
2016 National Health & Medical Research Council Project Grant APP1102172 “A Phase I Study of PiggyBac CD19 Specific Chimeric Antigen Receptor T-cells for Therapy of Persistent and Relapsed B-cell Leukaemia and Lymphoma Post Allogeneic Stem Cell Transplantation (The CARTELL Study)”. Amount awarded: $357,589.80. Role Chief Investigator F.

Research

Research activities:

Current Research

2008-13 Functional mutagenesis to identify genes associated with glucocorticoid resistance in acute lymphoblastic leukaemia
2010- Coordinating clinical investigator for SIOPEN high risk neuroblastoma clinical trial (SIOPEN HR NBL-1)
2010- High density microarrays to identify targets for minimal residual disease detection
2014- Finding new treatments for ALK+ve inflammatory myofibroblastic tumours
2014- Establishment of patient-derived xenograft (PDX) models for high risk neuroblastoma
2013- The ASSET (Acute Lymphoblastic Leukaemia Subtype and Side-Effects from Treatment) study
2014- Personalised Medicine Program, Kids Cancer Centre & Children’s Cancer Institute

Socio-economic Objective (SEO) tags:

Clinical Health (Organs, Diseases and Abnormal Conditions)

Field of Research (FOR) Tag:

Cancer Therapy (excl. Chemotherapy and Radiation Therapy)

Solid Tumours

Haematological Tumours

Molecular Targets

Teaching & Supervision

I am available to supervise:

Yes

Currently supervising:

Current PhD Students under supervision

2013- Dr Marion Mateos. Project title: ERASE: Evaluation of Risk of ALL Treatment-related Side-Effects. Children’s Cancer Institute & School of Women’s and Children’s Health, University of New South Wales.
2016- Ms Ashleigh Fordham. Project title: “New treatments for paediatric ALK-rearranged inflammatory myofibroblastic tumours” Children’s Cancer Institute, Lowy Cancer Centre, University of New South Wales

Media

Facebook:

https://www.facebook.com/UNSWWomensChildrensHealth/

LinkedIn:

https://www.linkedin.com/in/toby-trahair-1b2528126?trk=hp-identity-name

Publications related to this Person

Journal articles

Berlanga P; Pasqualini C; Pötschger U; Sangüesa C; Castellani MR; Cañete A; Luksch R; Elliot M; Schreier G; Kropf M; Morgenstern D; Papadakis V; Ash S; Ruud E; Brock P; Wieczorek A; Kogner P; Trahair T; Ambros P; Boterberg T; Castel V; Valteau-Couanet D; Ladenstein R, 2021, 'Central nervous system relapse in high-risk stage 4 neuroblastoma: The HR-NBL1/SIOPEN trial experience', European Journal of Cancer, vol. 144, pp. 1 - 8, http://dx.doi.org/10.1016/j.ejca.2020.10.020

Putra V; Hulme AJ; Tee AE; Sun JQJ; Atmadibrata B; Ho N; Chen J; Gao J; Norris MD; Haber M; Kavallaris M; Henderson MJ; McCarroll J; Trahair T; Liu T; Liu PY, 2021, 'The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma', Molecular Oncology, http://dx.doi.org/10.1002/1878-0261.12906

Wong M; Mayoh C; Lau LMS; Khuong-Quang DA; Pinese M; Kumar A; Barahona P; Wilkie EE; Sullivan P; Bowen-James R; Syed M; Martincorena I; Abascal F; Sherstyuk A; Bolanos NA; Baber J; Priestley P; Dolman MEM; Fleuren EDG; Gauthier ME; Mould EVA; Gayevskiy V; Gifford AJ; Grebert-Wade D; Strong PA; Manouvrier E; Warby M; Thomas DM; Kirk J; Tucker K; O’Brien T; Alvaro F; McCowage GB; Dalla-Pozza L; Gottardo NG; Tapp H; Wood P; Khaw SL; Hansford JR; Moore AS; Norris MD; Trahair TN; Lock RB; Tyrrell V; Haber M; Marshall GM; Ziegler DS; Ekert PG; Cowley MJ, 2020, 'Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer', Nature Medicine, vol. 26, pp. 1742 - 1753, http://dx.doi.org/10.1038/s41591-020-1072-4

Fordham AM; Xie J; Gifford AJ; Wadham C; Morgan LT; Mould EVA; Fadia M; Zhai L; Massudi H; Ali ZS; Marshall GM; Lukeis RE; Fletcher JI; MacKenzie KL; Trahair TN, 2020, 'CD30 and ALK combination therapy has high therapeutic potency in RANBP2-ALK-rearranged epithelioid inflammatory myofibroblastic sarcoma', British Journal of Cancer, vol. 123, pp. 1101 - 1113, http://dx.doi.org/10.1038/s41416-020-0996-2

Lee S; Nath CE; Balzer BWR; Lewis CR; Trahair TN; Anazodo AC; Shaw PJ, 2020, 'An HPLC-PDA Method for Determination of Alectinib Concentrations in the Plasma of an Adolescent', Acta Chromatographica, vol. 32, pp. 166 - 169, http://dx.doi.org/10.1556/1326.2019.00578

Salik B; Yi H; Hassan N; Santiappillai N; Vick B; Connerty P; Duly A; Trahair T; Woo AJ; Beck D; Liu T; Spiekermann K; Jeremias I; Wang J; Kavallaris M; Haber M; Norris MD; Liebermann DA; D'Andrea RJ; Murriel C; Wang JY, 2020, 'Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia', Cancer Cell, vol. 38, pp. 263 - 278.e6, http://dx.doi.org/10.1016/j.ccell.2020.05.014

Mateos MK; Tulstrup M; Quinn MCJ; Tuckuviene R; Marshall GM; Gupta R; Mayoh C; Wolthers BO; Barbaro PM; Ruud E; Sutton R; Huttunen P; Revesz T; Trakymiene SS; Barbaric D; Tedgård U; Giles JE; Alvaro F; Jonsson OG; Mechinaud F; Saks K; Catchpoole D; Kotecha RS; Dalla-Pozza L; Chenevix-Trench G; Trahair TN; Macgregor S; Schmiegelow K, 2020, 'Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children', Cancers, vol. 12, http://dx.doi.org/10.3390/cancers12051285

Mckenna JE; Trahair T, 2020, 'Bronchial carcinoid tumour identified as the cause for recurrent pneumonia in a 10-year-old boy', Journal of Paediatrics and Child Health, vol. 56, pp. 642 - 644, http://dx.doi.org/10.1111/jpc.14623

Xie J; Span M; van Maarseveen E; Langenhorst J; Boddy AV; Sia KCS; Sutton R; Venn N; Punt AM; Tyrrell V; Haber M; Trahair T; Lau L; Marshall GM; Lock RB, 2020, 'Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia', Pediatric Blood and Cancer, vol. 67, pp. e28133, http://dx.doi.org/10.1002/pbc.28133

Berry NK; Scott RJ; Sutton R; Law T; Trahair TN; Dalla-Pozza L; Ritchie P; Barbaric D; Enjeti AK, 2020, 'Enrichment of atypical hyperdiploidy and IKZF1 deletions detected by SNP-microarray in high-risk Australian AIEOP-BFM B-cell acute lymphoblastic leukaemia cohort', Cancer Genetics, vol. 242, pp. 8 - 14, http://dx.doi.org/10.1016/j.cancergen.2020.01.051

Ladenstein R; Pötschgerulrike.poetschger@ccri.at U; Valteau-couanet D; Luksch R; Castel V; Ash S; Laureys G; Brock P; Michon JM; Owenscormac.owens@olchc.ie C; Trahair T; Chan GCF; Ruud E; Schroeder H; Beck-popovic M; Schreier G; Loibner H; Ambros P; Holmes K; Castellani MR; Gaze MN; Garaventa A; Pearson ADJ; Lode HN, 2020, 'Investigation of the role of dinutuximab beta-based immunotherapy in the siopen high-risk neuroblastoma 1 trial (HR-NBL1)', Cancers, vol. 12, http://dx.doi.org/10.3390/cancers12020309

Kamili A; Atkinson C; Trahair TN; Fletcher JI, 2020, 'Mouse models of high-risk neuroblastoma', Cancer and Metastasis Reviews, http://dx.doi.org/10.1007/s10555-020-09855-0

Kamili A; Gifford AJ; Li N; Mayoh C; Chow S-O; Failes TW; Eden GL; Cadiz R; Xie J; Lukeis RE; Norris MD; Haber M; McCowage GB; Arndt GM; Trahair TN; Fletcher JI, 2020, 'Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy', British Journal of Cancer, http://dx.doi.org/10.1038/s41416-019-0682-4

Holmes K; Pötschger U; Pearson ADJ; Sarnacki S; Cecchetto G; Gomez-Chacon J; Squire R; Freud E; Bysiek A; Matthyssens LE; Metzelder M; Monclair T; Stenman J; Rygl M; Rasmussen L; Joseph JM; Irtan S; Avanzini S; Godzinski J; Björnland K; Elliott M; Luksch R; Castel V; Ash S; Balwierz W; Laureys G; Ruud E; Papadakis V; Malis J; Owens C; Schroeder H; Beck-Popovic M; Trahair T; de Lacerda AF; Ambros PF; Gaze MN; McHugh K; Valteau-Couanet D; Ladenstein RL, 2020, 'Influence of Surgical Excision on the Survival of Patients with Stage 4 High-Risk Neuroblastoma: A Report from the HR-NBL1/SIOPEN Study', Journal of Clinical Oncology, vol. 38, pp. 2902 - 2915, http://dx.doi.org/10.1200/JCO.19.03117

Lynch JR; Salik B; Connerty P; Vick B; Leung H; Pijning A; Jeremias I; Spiekermann K; Trahair T; Liu T; Haber M; Norris MD; Woo AJ; Hogg P; Wang J; Wang JY, 2019, 'JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis', Leukemia, vol. 33, pp. 1400 - 1410, http://dx.doi.org/10.1038/s41375-018-0354-z

Mateos MK; Trahair TN; Mayoh C; Barbaro PM; Sutton R; Revesz T; Barbaric D; Giles JE; Alvaro F; Mechinaud F; Catchpoole D; Kotecha RS; Dalla-Pozza L; Quinn MCJ; MacGregor S; Chenevix-Trench G; Marshall GM, 2019, 'Risk factors for symptomatic venous thromboembolism during therapy for childhood acute lymphoblastic leukemia', Thrombosis Research, vol. 178, pp. 132 - 138, http://dx.doi.org/10.1016/j.thromres.2019.04.011

Boutros R; Catchpoole D; Collins K; Cross S; Downie P; Drinkwater C; Fletcher J; Gottardo N; Hunter S; Kirby M; Ludlow L; MacNish M; Maybury M; Moore A; Morrin H; Purdy S; Revesz T; Saffery R; Strong R; Trahair T; Wood A; Byrne J, 2019, 'The Australian and New Zealand Children's Haematology/Oncology Group Biobanking Network', Biopreservation and Biobanking, vol. 17, pp. 95 - 97, http://dx.doi.org/10.1089/bio.2019.0013

Gamble LD; Purgato S; Murray J; Xiao L; Yu DMT; Hanssen KM; Giorgi FM; Carter DR; Gifford AJ; Valli E; Milazzo G; Kamili A; Mayoh C; Liu B; Eden G; Sarraf S; Allan S; Giacomo SD; Flemming CL; Russell AJ; Cheung BB; Oberthuer A; London WB; Fischer M; Trahair TN; Fletcher JI; Marshall GM; Ziegler DS; Hogarty MD; Burns MR; Perini G; Norris MD; Haber M, 2019, 'Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma', Science Translational Medicine, vol. 11, http://dx.doi.org/10.1126/scitranslmed.aau1099

Trahair T; Gifford AJ; Fordham A; Mayoh C; Fadia M; Lukeis R; Wood AC; Valvi S; Walker RD; Blackburn J; Heyer EE; Mercer TR; Barbaric D; Marshall GM; MacKenzie KL, 2019, 'Crizotinib and surgery for long-term disease control in children and adolescents with ALK-positive inflammatory myofibroblastic tumors', JCO Precision Oncology, vol. 3, pp. 1 - 11, http://dx.doi.org/10.1200/PO.18.00297

Balzer B; Loo C; Wegner E; Nath C; Lee S; Smith C; Lewis C; Trahair T; Anazodo A, 2018, 'Alectinib is effective, safe and tolerable in an adolescent with stage IVB ALK-rearranged adenocarcinoma of the lung.', Pediatric Hematology-Oncology, pp. 1 - 7, http://dx.doi.org/10.1080/08880018.2018.1541492

Tsoli M; Wadham C; Pinese M; Failes T; Joshi S; Mould E; Yin JX; Gayevskiy V; Kumar A; Kaplan W; Ekert PG; Saletta F; Franshaw L; Liu J; Gifford A; Weber MA; Rodriguez M; Cohn RJ; Arndt G; Tyrrell V; Haber M; Trahair T; Marshall GM; McDonald K; Cowley MJ; Ziegler DS, 2018, 'Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer', Cancer Biology and Therapy, vol. 19, pp. 1078 - 1087, http://dx.doi.org/10.1080/15384047.2018.1491498

Ladenstein R; Pötschger U; Valteau-Couanet D; Luksch R; Castel V; Yaniv I; Laureys G; Brock P; Michon JM; Owens C; Trahair T; Chan GCF; Ruud E; Schroeder H; Beck Popovic M; Schreier G; Loibner H; Ambros P; Holmes K; Castellani MR; Gaze MN; Garaventa A; Pearson ADJ; Lode HN, 2018, 'Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial', The Lancet Oncology, vol. 19, pp. 1617 - 1629, http://dx.doi.org/10.1016/S1470-2045(18)30578-3

Vedi A; Mitchell R; Shanmuganathan S; Oswald C; Marshall GM; Trahair T; Sivarajasingam S; Ziegler DS, 2018, 'Increased Survival for Children with Acute Myeloid Leukemia Results from Improved Postrelapse Treatment', Journal of Pediatric Hematology/Oncology, vol. 40, pp. 541 - 547, http://dx.doi.org/10.1097/MPH.0000000000001215

Balzer BW; Loo C; Lewis CR; Trahair TN; Anazodo A, 2018, 'Adenocarcinoma of the Lung in Childhood and Adolescence: a systematic review.', J Thorac Oncol., vol. 18, pp. 33035 - 33035, http://dx.doi.org/10.1016/j.jtho.2018.08.2020.

Matsuno R; Gifford AJ; Fang J; Warren M; Lukeis RE; Trahair T; Sugimoto T; Marachelian A; Asgharzadeh S; Maris JM; Ikegaki N; Shimada H, 2018, 'Rare MYC-amplified Neuroblastoma With Large Cell Histology', Pediatric and Developmental Pathology, vol. 21, pp. 461 - 466, http://dx.doi.org/10.1177/1093526617749670

Fletcher JI; Ziegler DS; Trahair TN; Marshall GM; Haber M; Norris MD, 2018, 'Too many targets, not enough patients: Rethinking neuroblastoma clinical trials', Nature Reviews Cancer, vol. 18, pp. 389 - 400, http://dx.doi.org/10.1038/s41568-018-0003-x

Vetsch J; Wakefield CE; Robertson EG; Trahair TN; Mateos MK; Grootenhuis M; Marshall GM; Cohn RJ; Fardell JE, 2018, 'Health-related quality of life of survivors of childhood acute lymphoblastic leukemia: a systematic review', Quality of Life Research, vol. 27, pp. 1431 - 1443, http://dx.doi.org/10.1007/s11136-018-1788-5

Sutton R; Venn NC; Law T; Boer JM; Trahair TN; Ng A; Den Boer ML; Dissanayake A; Giles JE; Dalzell P; Mayoh C; Barbaric D; Revesz T; Alvaro F; Pieters R; Haber M; Norris MD; Schrappe M; Dalla Pozza L; Marshall GM, 2018, 'A risk score including microdeletions improves relapse prediction for standard and medium risk precursor B-cell acute lymphoblastic leukaemia in children', British Journal of Haematology, vol. 180, pp. 550 - 562, http://dx.doi.org/10.1111/bjh.15056

Afrin S; Zhang CRC; Meyer C; Stinson CL; Pham T; Bruxner TJC; Venn NC; Trahair TN; Sutton R; Marschalek R; Lynn Fink J; Moore AS, 2018, 'Targeted Next-Generation Sequencing for Detecting MLL Gene Fusions in Leukemia', Molecular Cancer Research, vol. 16, pp. 279 - 285, http://dx.doi.org/10.1158/1541-7786.MCR-17-0569

Balzer BWR; Loo C; Lewis CR; Trahair TN; Anazodo AC, 2018, 'Adenocarcinoma of the Lung in Childhood and Adolescence: A Systematic Review', Journal of Thoracic Oncology, http://dx.doi.org/10.1016/j.jtho.2018.08.2020

Norman M; David C; Wainstein B; Ziegler JB; Cohn R; Mitchell R; O'Brien T; Russell S; Trahair T; Trickett A; Frith K; Gray P, 2017, 'Haematopoietic stem cell transplantation for primary immunodeficiency syndromes: A 5-year single-centre experience', Journal of Paediatrics and Child Health, vol. 53, pp. 988 - 994, http://dx.doi.org/10.1111/jpc.13643

Fardell JE; Vetsch J; Trahair T; Mateos MK; Grootenhuis MA; Touyz LM; Marshall GM; Wakefield CE, 2017, 'Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review', Pediatric Blood and Cancer, vol. 64, http://dx.doi.org/10.1002/pbc.26489

Trahair T; Sorrentino S; Russell SJ; Sampaio H; Selek L; Plantaz D; Freycon C; Simon T; Kraal K; Beck-Popovic M; Haupt R; Ash S; De Bernardi B, 2017, 'Spinal Canal Involvement in Neuroblastoma', Journal of Pediatrics, vol. 188, pp. 294 - 298, http://dx.doi.org/10.1016/j.jpeds.2017.05.051

Ng M; Forsyth V; Trahair T; Carrington N; Anazodo A, 2017, 'Adolescents, young adults and cancer: What GPs need to know.', Medicine Today, vol. 18(8):, pp. 14 - 22, https://medicinetoday.com.au/2017/august/feature-article/adolescents-young-adults-and-cancer-what-gps-need-know

Ladenstein R; Pötschger U; Pearson ADJ; Brock P; Luksch R; Castel V; Yaniv I; Papadakis V; Laureys G; Malis J; Balwierz W; Ruud E; Kogner P; Schroeder H; de Lacerda AF; Beck-Popovic M; Bician P; Garami M; Trahair T; Canete A; Ambros PF; Holmes K; Gaze M; Schreier G; Garaventa A; Vassal G; Michon J; Valteau-Couanet D, 2017, 'Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial', The Lancet Oncology, vol. 18, pp. 500 - 514, http://dx.doi.org/10.1016/S1470-2045(17)30070-0

Shadur B; Trahair TN; O'Brien T; Russell SJ; Ziegler JB, 2017, 'Desensitisation to liposomal amphotericin B', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, vol. 5, pp. 181 - 183, http://dx.doi.org/10.1016/j.jaip.2016.08.006

Trahair TN; Lock RB; Sutton R; Sia KCS; Evans K; Richmond J; Law T; Venn NC; Irving JA; Moore S; Nievergall E; Dang P; Heatley SL; White DL; Revesz T, 2016, 'Xenograft-directed personalized therapy for a patient with post-transplant relapse of ALL', Bone Marrow Transplantation, vol. 51, pp. 1279 - 1282, http://dx.doi.org/10.1038/bmt.2016.122

Chang W; Brohl AS; Patidar R; Sindiri S; Shern JF; Wei JS; Song YK; Yohe ME; Gryder B; Zhang S; Calzone KA; Shivaprasad N; Wen X; Badgett TC; Miettinen M; Hartman KR; League-Pascual JC; Trahair TN; Widemann BC; Merchant MS; Kaplan RN; Lin JC; Khan J, 2016, 'Multidimensional clinomics for precision therapy of children and adolescent young adults with relapsed and refractory cancer: A report from the center for cancer research', Clinical Cancer Research, vol. 22, pp. 3810 - 3820, http://dx.doi.org/10.1158/1078-0432.CCR-15-2717

Kim PY; Tan O; Liu B; Trahair T; Liu T; Haber M; Norris MD; Marshall GM; Cheung BB, 2016, 'High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients', Cancer Letters, vol. 374, pp. 315 - 323, http://dx.doi.org/10.1016/j.canlet.2016.02.021

Sun Y; Bell JL; Carter D; Gherardi S; Poulos RC; Milazzo G; Wong JWH; Al-Awar R; Tee AE; Liu PY; Liu B; Atmadibrata B; Wong M; Trahair T; Zhao Q; Shohet JM; Haupt Y; Schulte JH; Brown PJ; Arrowsmith CH; Vedadi M; MacKenzie KL; Hüttelmaier S; Perini G; Marshall GM; Braithwaite A; Liu T, 2015, 'WDR5 supports an N-myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma', Cancer Research, vol. 75, pp. 5143 - 5154, http://dx.doi.org/10.1158/0008-5472.CAN-15-0423

Sutton R; Shaw PJ; Venn NC; Law T; Dissanayake A; Kilo T; Haber M; Norris MD; Fraser C; Alvaro F; Revesz T; Trahair TN; Dalla-Pozza L; Marshall GM; O'Brien TA, 2015, 'Persistent MRD before and after allogeneic BMT predicts relapse in children with acute lymphoblastic leukaemia', British Journal of Haematology, vol. 168, pp. 395 - 404, http://dx.doi.org/10.1111/bjh.13142

Bartlett A; Goeman E; Vedi A; Mostaghim M; Trahair T; O’Brien TA; Palasanthiran P; McMullan B, 2015, 'A pilot study of a computerized decision support system to detect invasive fungal infection in pediatric hematology/oncology patients', Infection Control and Hospital Epidemiology, vol. 36, pp. 1313 - 1317, http://dx.doi.org/10.1017/ice.2015.179

Kim PY; Tan O; Diakiw SM; Carter D; Sekerye EO; Wasinger VC; Liu T; Kavallaris M; Norris MD; Haber M; Chesler L; Dolnikov A; Trahair TN; Cheung NK; Marshall GM; Cheung BB, 2014, 'Identification of plasma Complement C3 as a potential biomarker for neuroblastoma using a quantitative proteomic approach', Journal of Proteomics, vol. 96, pp. 1 - 12, http://dx.doi.org/10.1016/j.jprot.2013.10.032

Pasquier E; Trahair T; Kavallaris M; Andre N, 2013, 'Reply: Comment on 'beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma'-β- blockers are potent anti-angiogenic and chemo-sensitising agents, rather than cytotoxic drugs', British Journal of Cancer, vol. 109, pp. 2024 - 2025, http://dx.doi.org/10.1038/bjc.2013.498

Pasquier E; Street J; Pouchy C; Carre M; Gifford AJ; Murray J; Norris MD; Trahair T; Andre N; Kavallaris M, 2013, 'B-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma', British Journal of Cancer, vol. 108, pp. 2485 - 2494, http://dx.doi.org/10.1038/bjc.2013.205

Sekyere E; Thomas WD; Keating J; Calao M; Cui HJ; Chen JB; Raif A; Jankowski K; Cheung B; Davies NP NP; Trahair TN; Liu T; Wainwright BJ; Ding HF; Marshall GM, 2013, 'Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation', Oncogene, vol. 32, pp. 3616 - 3626, http://dx.doi.org/10.1038/onc.2012.368

Malyukova A; Papa R; O'Brien R; Giles JE; Trahair TN; Pozza LD; Sutton R; Liu T; Haber M; Norris MD; Lock RB; Marshall GM; Giles J, 2013, 'FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation', Leukemia, vol. 27, pp. 1053 - 1062, http://dx.doi.org/10.1038/leu.2012.361

Mateos MK; O'Brien TA; Oswald C; Ziegler DS; Cohn RJ; Russell SJ; Barbaric D; Marshall GM; Trahair TN; Gabriel M, 2013, 'Transplant-related mortality following allogeneic hematopoeitic stem cell transplantation for pediatric acute lymphoblastic leukemia: 25-year retrospective review', Pediatric Blood and Cancer, vol. 60, pp. 1520 - 1527, http://dx.doi.org/10.1002/pbc.24559

Elahi MM; Houng C; Trahair T; Ravindranathan H; Grant PW, 2012, 'Extracorporeal Membrane Oxygenation Support in a Situation of Diagnostic Dilemma', Heart Lung and Circulation, vol. 21, pp. 821 - 823, http://dx.doi.org/10.1016/j.hlc.2012.04.014

Bhadri V; Trahair TN; Lock RB; bhadri , 2012, 'Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia', Journal of Paediatrics and Child Health, vol. 48, pp. 634 - 640, http://dx.doi.org/10.1111/j.1440-1754.2011.02212.x

Marsh DJ; Trahair TN; Kirk EP, 2011, 'Mutant AKT1 in Proteus Syndrome', New England Journal of Medicine, vol. 365, pp. 2141 - 2142, http://dx.doi.org/10.1056/NEJMc1111367

Bhadri VA; Satharasinghe K; Sugo E; Barbaric D; Trahair TN, 2011, 'Excellent response to dasatinib of childhood Philadelphia positive intracranial acute lymphoblastic leukaemia tumours', British Journal of Haematology, vol. 152, pp. 347 - 349, http://dx.doi.org/10.1111/j.1365-2141.2010.08465.x

Bhadri V; Cowley MJ; Kaplan W; Trahair TN; Lock RB, 2011, 'Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia', BMC Genomics, vol. 12, pp. 1 - 13, http://dx.doi.org/10.1186/1471-2164-12-565

Marshall GM; Liu PY; Gherardi S; Scarlett CJ; Bedalov A; Xu N; Iraci N; Valli E; Ling D; Thomas W; Van bekkum M; Sekyere E; Jankowski K; Trahair T; Mackenzie K; Haber M; Norris MD; Biankin AV; Perini G; Liu T, 2011, 'SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability', PLOS Genetics, vol. 7, pp. e1 - e14, http://dx.doi.org/10.1371/journal.pgen.1002135

Marshall GM; Gherardi S; Xu N; Neiron Z; Trahair TN; Scarlett CJ; Chang DK; Liu PY; Jankowski K; Iraci N; Haber M; Norris MD; Keating J; Sekyere E; Jonquieres G; Biankin AV; Stossi F; Katzenellenbogen BS; Perini G; Liu T, 2010, 'Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects', Oncogene, vol. 29, pp. 5957 - 5968, http://dx.doi.org/10.1038/onc.2010.332

Satharasinghe K; Trahair TN; Barbaric D; O'Brien TA; Russell SJ; Cohn RJ; Marshall GM; Ziegler DS, 2009, 'False-positive MIBG scans with normal computed tomography imaging in patients with high-risk neuroblastoma', Journal of Clinical Oncology, vol. 27, http://dx.doi.org/10.1200/JCO.2009.24.0036

Trahair TN; Wainstein B; Manton N; Bourne A; Ziegler JB; Rice M; Russell SJ, 2008, 'Rituximab for lymphoproliferative disease prior to haematopoietic stem cell transplantation for X-linked severe combined immunodeficiency', Pediatric Blood and Cancer, vol. 50, pp. 366 - 369, http://dx.doi.org/10.1002/pbc.20887

Marsh DJ; Trahair TN; Martin J; Chee W; Walker JL; Kirk EP; Baxter RC; Marshall GM, 2008, 'Rapamycin treatment for a child with germline PTEN mutation', Nature Clinical Practice Oncology, vol. 5, pp. 357 - 361, http://dx.doi.org/10.1038/ncponc1112

Trahair TN; Vowels MR; Johnston K; Cohn RJ; Russell SJ; Neville KA; Carroll S; Marshall GM, 2007, 'Long-term outcomes in children with high-risk neuroblastoma treated with autologous stem cell transplantation', Bone Marrow Transplantation, vol. 40, pp. 741 - 746, http://dx.doi.org/10.1038/sj.bmt.1705809

Trahair TN; Andrews L; Cohn RJ, 2007, 'Recognition of Li Fraumeni syndrome at diagnosis of a locally advance extremity rhabdomyosarcoma', Pediatric Blood and Cancer, vol. 48, pp. 345 - 348, http://dx.doi.org/10.1002/pbc.20795

Ziegler DS; Russell SJ; Rozenberg G; James CA; Trahair TN; O'Brien TA, 2005, 'Goats' milk quackery', Journal of Paediatrics and Child Health, vol. 41, pp. 569 - 571, http://dx.doi.org/10.1111/j.1440-1754.2005.00723.x

Trahair T; Cohn R; Russell S; Marshall GM; Pokorny CS, 2004, 'Investigation of the child with easy bruising', Medicine Today, vol. 5, pp. 61 - 69

Fleming J; Ginn SL; Weinberger RP; Trahair TN; Smythe JA; Alexander IE, 2001, 'Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons', Human Gene Therapy, vol. 12, pp. 77 - 86, http://dx.doi.org/10.1089/104303401450997

Trahair TN; Alexander IE; Rowe PB; Smythe JA, 2000, 'The adenovirus E4 ORF6 and E1b 55 kDa proteins cooperate in a p53-independent manner to enhance transduction by recombinant adeno-associated virus vectors', Journal of General Virology, vol. 81, pp. 2983 - 2991, http://dx.doi.org/10.1099/0022-1317-81-12-2983

Dos Remedios CG; Berry DA; Carter LK; Coumans JV; Heinke MY; Kiessling PC; Seeto RK; Thorvaldson T; Trahair T; Yeoh T; Gunning PW; Hardeman E; Humphery-Smith I; Naidoo D; Keogh A, 1996, 'Different electrophoretic techniques produce conflicting data in the analysis of myocardial samples from dilated cardiomyopathy patients: protein levels do not necessarily reflect mRNA levels', Electrophoresis, vol. 17, pp. 235 - 238, http://dx.doi.org/10.1002/elps.1150170140

Trahair T; Yeoh T; Cartmill T; Keogh A; Spratt P; Chang V; dos Remedios CG; Gunning P, 1993, 'Myosin Light Chain Gene Expression Associated with Disease States of the Human Heart', Journal of Molecular and Cellular Cardiology, vol. 25, pp. 577 - 585, http://dx.doi.org/10.1006/jmcc.1993.1067

Conference Papers

Robertson EG; Mitchell R; Wakefield CE; Lewis P; Cousens N; Marshall GM; Russell SJ; Ziegler DS; Anazodo AC; Trahair TN; Barbaric D; Cohn RJ; Alvaro F; O'Brien T, 2018, 'Enrolment in early phase paediatric oncology clinical trials: the healthcare professionals’ perspective (poster)', in Enrolment in early phase paediatric oncology clinical trials: the healthcare professionals’ perspective (poster), Australian and New Zealand Children’s Haematology and Oncology Group (ANZCHOG), Sydney, presented at Australian and New Zealand Children’s Haematology and Oncology Group (ANZCHOG), Sydney, 14 June 2018 - 16 June 2018

Namasivayam M; Zaunders J; Ip S; Scott GM; Shaw P; Trahair TN; O''brien T; Rawlinson WD; Walls T; Kelleher AD; Ziegler JB, 2011, 'Performance of quantiferon-cmv (r) and whole-blood cd4(+)cd25(+)cd134(+) assays in identification of human cytomegalovirus-specific t-cells in children post-haematopoietic stem cell transplantation', in Internal Medicine Journal, Blackwell Publishing Asia, pp. 12 - 12, http://dx.doi.org/10.1111/%28ISSN%291445-5994

Conference Posters

Shadur B; Trahair TN; O'Brien T; Russell SJ; Ziegler JB, 2017, 'Desensitisation to liposomal amphotericin B', in Journal of Allergy and Clinical Immunology: In Practice, Vol. 5, pp. 181 - 183, http://dx.doi.org/10.1016/j.jaip.2016.08.006

Conference Presentations

White V; Anazodo AC; Bibby H; Orme L; Conyers R; Nicholls W; Pinkerton R; Harrup R; Osborn M; Philips M; Trahair T; Thompson K; Green M; Coory M, 2015, 'Management of Bone Cancers in Australian Adolescents and Young Adults (AYAs).', in Management of Bone Cancers in Australian Adolescents and Young Adults (AYAs)., Clinical Oncology Society of Australia’s Annual Scientific meeting, Hobart, Australia., Hobart Australia, presented at Clinical Oncology Society of Australia’s Annual Scientific meeting, Hobart, Australia., Hobart Australia, 17 November 2015 - 19 November 2015

Conference Abstracts

Lin B; Kennedy B; McBride J; Dalla-Pozza L; Trahair T; McCowage G; Coward E; Plush L; Robinson PD; Hardaker K; Widger J; Ng A; Jaffe A; Selvadurai H, 2019, 'Long-term morbidity of respiratory viral infections during chemotherapy in children with leukaemia', in Pediatric Pulmonology, WILEY, Vol. 54, pp. 1821 - 1829, http://dx.doi.org/10.1002/ppul.24456

Afrin S; Zhang CRC; Meyer C; Maybury M; Pham T; Venn N; Trahair TN; Sutton R; Marschalek R; Fink L; Moore AS, 2018, 'Quantitative Analysis of MLL Fusion Transcripts By Droplet Digital PCR to Monitor Minimal Residual Disease in MLL-Rearranged Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, Vol. 132, presented at 60th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego, CA, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-117761

Wakefield CE; Vetsch J; Tucker KM; Warby M; O'Brien T; Techakesari P; Glenn M; Trahair TN; Marron JM; Lau L; Tyrell V; Ziegler D, 2018, 'Families' and Healthcare Professionals' Hopes and Expectations Participating in a Precision Medicine Trial for Children with High-Risk Cancer: The PRISM-Impact Study', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 65, pp. S62 - S62, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445195000120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Robertson EG; Mitchell R; Wakefield CE; Lewis P; Cousens N; Marshall GM; Russell SJ; Ziegler DS; Anazodo A; Trahair TN; Barbaric D; Cohn RJ; Alvaro F; O'Brien TA, 2018, 'Enrolment in early phase paediatric oncology clinical trials: the healthcare professionals’ perspective.', in PSYCHO-ONCOLOGY, WILEY, Hong Kong, Vol. 27, pp. 56 - 57, presented at International Psycho-Oncology Society, Hong Kong, 31 October 2018 - 02 November 2018, http://dx.doi.org/10.1111/jpc.14248

Vetsch J; Wakefield CE; Tucker K; Warby M; Techakesari P; Marshall G; Trahair TN; O'Brien T; Marron JM; Lau L; Tyrell V; Ziegler D, 2018, 'The PRISM-IMPACT study: What are the hopes and expectations of families and health care professionals enrolling in a personalised medicine trial for high risk childhood cancers?', in EUROPEAN JOURNAL OF HUMAN GENETICS, NATURE PUBLISHING GROUP, Milan, ITALY, Vol. 27, pp. 690 - 691, presented at 51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG), Milan, ITALY, 16 June 2018 - 19 June 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489313105140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Robertson EG; Mitchell R; Wakefield CE; Lewis P; Cousens N; Marshall GM; Russell SJ; Ziegler DS; Anazodo A; Trahair TN; Barbaric D; Cohn RJ; Alvaro F; O'Brien TA, 2018, 'Enrolment in early phase paediatric oncology clinical trials: the healthcare professionals’ perspective.', in Journal of Paediatrics and Child Health, Hong Kong, presented at International Psycho-Oncology Society, Hong Kong, 31 October 2018 - 02 November 2018, http://dx.doi.org/10.1111/jpc.14248

Mateos MK; Trahair TN; Mayoh C; Barbaro PM; George C; Sutton R; Revesz T; Barbaric D; Giles J; Alvaro F; Mechinaud FM; Catchpoole DR; Kotecha RS; Quinn MCJ; Chenevix-Trench G; MacGregor S; Dalla-Pozza L; Marshall GM, 2017, 'Clinical and Germline Risk Factors for the Occurrence of Multiple Treatment Toxicities during Childhood Acute Lymphoblastic Leukemia (ALL) Therapy', in BLOOD, AMER SOC HEMATOLOGY, Atlanta, GA, Vol. 130, presented at 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA, 09 December 2017 - 12 December 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432419405157&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mateos MK; Trahair TN; Mayoh C; Barbaro PM; Sutton R; Revesz T; Barbaric D; Giles J; Alvaro F; Mechinaud F; Catchpoole D; Kotecha RS; Dalla-Pozza L; Marshall GM, 2016, 'Clinical Predictors of Venous Thromboembolism during Therapy for Childhood Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, Vol. 128, presented at 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego, CA, 03 December 2016 - 06 December 2016, http://dx.doi.org/10.1182/blood.V128.22.1182.1182

Afrin S; Meyer C; Stinson CL; Thy P; Bruxner TJC; Venn NC; Trahair TN; Sutton R; Marschalek R; Fink L; Moore AS, 2016, 'Identification of Multiple, Patient-Specific MLL Fusion Transcript Isoforms in Childhood Leukemia Using Anchored Multiplex PCR-Based Enrichment (AMP-E)', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, Vol. 128, presented at 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego, CA, 03 December 2016 - 06 December 2016, http://dx.doi.org/10.1182/blood.V128.22.2908.2908

Sartor M; Barbaric D; Law T; Dissanayake A; Venn NC; Karsa M; Wong SWJ; Norris MD; Revesz T; Ritchie P; Shaw PJ; Bradstock KF; Pozza LD; Trahair TN; Sutton R, 2015, 'Improved Concordance of Minimal Residual Disease Measurements By Quantitative PCR and 10-Color Flow Cytometry in Pediatric Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, Vol. 126, presented at 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368020102126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

School of Women's and Children's Health

Dr Toby Trahair

Tabs

Current Research

Study @ WCH

Research @ WCH

Quick Links

Connect