Dr Usha Krishnan

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Discipline:

Paediatrics

Dr Usha Krishnan is a Senior Lecturer with the School of Women's & Children's Health. She is also the director of the only paediatric motility service and dedicated multidisciplinary oesophageal atresia-tracheoesophageal fistula clinic in the state. Her research interests lies in childhood motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease and reflux aspiration, growth and nutrition, eosinophilic esophagitis, gut microbiome and oesophageal atresia.

School:

Sch Women's&Children's Health

University role:

Senior Staff Specialist in Paediatric Gastroenterology, Director of Motility Services, Director of Oesophageal Atresia-Tracheoesophageal Fistula Clinic

Qualifications:

MBBS; FRACP

Grants:

European Society for Pediatric Gastroenterology Hepatology and Nutrition Networking Grant 2017

Research

Research activities:

1. Eosinophilic esophagitis in Esophageal Atresia

2. Gastrointestinal and nutritional complications in children with Oesophageal Atresia

3. Oesophageal microbiome and risk for Barretts Esophagua in Oesophageal Atresia

4. Stool microbiome in Oesophageal Atresia

5. Role of multichannel impedance monitoring in children with gastroesophageal reflux disease

5. Gastric function in Oesophageal Atresia.

6. Role of pepsin as a biomarker of reflux aspiration

Socio-economic Objective (SEO) tags:

Child Health

Field of Research (FOR) Tag:

Paediatrics

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

ILP and ILP (Honours) Students in 2019

Research Areas of interest:

•1.Gastrointestinal motility disorders

•2. Oesophageal Atresia

•3. Eosinophilic oesophagitis

•4. Gastroesophageal reflux disease and reflux aspiration

•5. Growth and nutrition

Projects Available / Research Areas :

Effect of Ketogenic diet on gastroesophageal reflux, gastric and colonic function, growth and nutrition and quality of life in patients with seizure disorders
. Predictive factors for the prevalence of fungal oesophagitis in children
Increased risk for anaesthetic complications in children with oesophageal atresia
Radiation exposure risk in infants and children with oesophageal atresia
Dietary intake and predictors of malnutrition in children with oesophageal atresia
Effect of blenderised diet on gastric function and microbiome
Nature of Projects / Methodology:

• Quantitative research /Prospective study using symptom questionnaire and hands on clinical motility studies

–Effect of Ketogenic diet on gastroesophageal reflux, gastric and colonic function, growth and nutrition and quality of life in patients with seizure disorders

–

• Quantitative research /Prospective study using symptom questionnaire and hands on laboratory work

–Effect of blenderised diet on gastric function and microbiome

•Prospective study with patient contact and using validated questionnaires

–Dietary intake and predictors of malnutrition in children with oesophageal atresia

•Retrospective chart reviews

–Predictive factors for the prevalence of fungal oesophagitis in children

–Increased risk for anaesthetic complications in children with oesophageal atresia

–Radiation exposure risk in infants and children with oesophageal atresia

Clinical Exposure

–Students will be invited to attend clinics with the supervisor and take part in departmental journal club, academic meetings, histopathology and radiology meeting, observing endoscopy procedures in operating theatres

–Students will be encouraged to write up their ILP project for publication in a peer reviewed journal and presentation in national and international conferences
Location of projects:

Sydney Children’s Hospital

Contact Details:

Dr Usha Krishnan

Usha.krishnan@health.nsw.gov.au

(02) 93821752

Currently supervising:

ILP Projects:

1. Does reflux monitoring with multichannel intraluminal impedance affect clinical outcomes in children with gastroesophageal reflux disease (GORD)?

2. Biliary Atresia and Neonatal Cholestasis in neonates

Publications related to this Person

Journal articles

Mousa H; Krishnan U; Hassan M; Dall’Oglio L; Rosen R; Gottrand F; Faure C, 2017, 'How to Care for Patients with EA-TEF: The Known and the Unknown', Current Gastroenterology Reports, vol. 19, http://dx.doi.org/10.1007/s11894-017-0605-6

Pilli S; Jiwane A; Krishnan U, 2017, 'Quality of life in children who have undergone fundoplication surgery for the treatment of gastroesophageal reflux disease: A review of literature', Diseases of the Esophagus, vol. 30, http://dx.doi.org/10.1093/dote/dow017

Lopez RN; Krishnan U; Ooi CY, 2017, 'Enteritis with pneumatosis intestinalis following rotavirus immunisation in an infant with short bowel syndrome', BMJ Case Reports, vol. 2017, http://dx.doi.org/10.1136/bcr-2017-219482

Lopez RN; Ooi CY; Krishnan U, 2017, 'Early and Peri-operative Prognostic Indicators in Infants Undergoing Hepatic Portoenterostomy for Biliary Atresia: a Review', Current Gastroenterology Reports, vol. 19, http://dx.doi.org/10.1007/s11894-017-0555-z

Wanaguru D; Langusch C; Krishnan U; Varjavandi V; Jiwane A; Adams S; Henry G, 2017, 'Is fundoplication required after the Foker procedure for long gap esophageal atresia?', Journal of Pediatric Surgery, vol. 52, pp. 1117 - 1120, http://dx.doi.org/10.1016/j.jpedsurg.2016.12.014

Bowden MR; Ee LC; Krishnan U; O'Loughlin EV; Hardikar W; Carmody D; Hainsworth C; Jermyn V; Lee MM; Sawyer J, 2017, 'Family impact and infant emotional outcomes following diagnosis of serious liver disease or transplantation in infancy', Journal of Pediatric Gastroenterology and Nutrition, vol. 64, pp. 528 - 532, http://dx.doi.org/10.1097/MPG.0000000000001404

Menzies J; Hughes J; Leach S; Belessis Y; Krishnan U, 2017, 'Prevalence of malnutrition and feeding difficulties in children with esophageal atresia', Journal of Pediatric Gastroenterology and Nutrition, vol. 64, pp. e100 - e105, http://dx.doi.org/10.1097/MPG.0000000000001436

Webb NL; Jiwane A; Ooi CY; Nightinghale S; Adams SE; Krishnan U, 2017, 'Clinical significance of liver histology on outcomes in biliary atresia', Journal of Paediatrics and Child Health, vol. 53, pp. 252 - 256, http://dx.doi.org/10.1111/jpc.13371

Alhagamhmad MH; Lemberg DA; Day AS; Tan LZ; Ooi CY; Krishnan U; Gupta N; Munday JS; Leach ST, 2017, 'Advancing nutritional therapy: A novel polymeric formulation attenuates intestinal inflammation in a murine colitis model and suppresses pro-inflammatory cytokine production in ex-vivo cultured inflam', Clinical Nutrition, vol. 36, pp. 497 - 505, http://dx.doi.org/10.1016/j.clnu.2016.01.010

Chan LJ; Tan L; Dhaliwal J; Briglia F; Clarkson C; Krishnan U, 2016, 'Treatment outcomes for eosinophilic esophagitis in children with esophageal atresia', Diseases of the Esophagus, vol. 29, pp. 563 - 571, http://dx.doi.org/10.1111/dote.12368

Krishnan U; Mousa H; Dall'Oglio L; Homaira N; Rosen R; Faure C; Gottrand F, 2016, 'ESPGHAN-NASPGHAN guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with esophageal atresia-tracheoesophageal fistula', Journal of Pediatric Gastroenterology and Nutrition, vol. 63, pp. 550 - 570, http://dx.doi.org/10.1097/MPG.0000000000001401

Safe M; Cho J; Krishnan U, 2016, 'Combined multichannel intraluminal impedance and pH measurement in detecting gastroesophageal reflux disease in children', Journal of Pediatric Gastroenterology and Nutrition, vol. 63, pp. e98 - e106, http://dx.doi.org/10.1097/MPG.0000000000001396

Ooi CY; Jeyaruban C; Lau J; Katz T; Matson A; Bell SC; Adams SE; Krishnan U, 2016, 'High ambient temperature and risk of intestinal obstruction in cystic fibrosis', Journal of Paediatrics and Child Health, vol. 52, pp. 430 - 435, http://dx.doi.org/10.1111/jpc.13096

Pascoe E; Falvey T; Jiwane A; Henry G; Krishnan U, 2016, 'Outcomes of fundoplication for paediatric gastroesophageal reflux disease', Pediatric Surgery International, vol. 32, pp. 353 - 361, http://dx.doi.org/10.1007/s00383-015-3843-4

Tong S; Mallitt KA; Krishnan U, 2016, 'Evaluation of Gastroesophageal Reflux by Combined Multichannel Intraluminal Impedance and pH Monitoring and Esophageal Motility Patterns in Children with Esophageal Atresia', European Journal of Pediatric Surgery, vol. 26, pp. 322 - 331, http://dx.doi.org/10.1055/s-0035-1564715

Pascoe E; Falvey T; Jiwane A; Henry G; Krishnan U, 2015, 'Outcomes of fundoplication for paediatric gastroesophageal reflux disease', Pediatric Surgery International, pp. 1 - 9, http://dx.doi.org/10.1007/s00383-015-3843-4

Bowden MR; Stormon M; Hardikar W; Ee LC; Krishnan U; Carmody D; Jermyn V; Lee MM; O'Loughlin EV; Sawyer J, 2015, 'Family adjustment and parenting stress when an infant has serious liver disease: The Australian experience', Journal of Pediatric Gastroenterology and Nutrition, vol. 60, pp. 717 - 722, http://dx.doi.org/10.1097/MPG.0000000000000742

Tan LZ; Gifford AJ; Clarkson CM; Henry GM; Krishnan U, 2015, 'Barrett's esophagus and eosinophilic esophagitis in a young pediatric patient with esophageal atresia', Journal of Pediatric Surgery Case Reports, vol. 3, pp. 272 - 275, http://dx.doi.org/10.1016/j.epsc.2015.05.004

Krishnan U; Paul S; Messina I; Soma M, 2015, 'Correlation between laryngobronchoscopy and pepsin in the diagnosis of extra-oesophageal reflux', Journal of Laryngology and Otology, vol. 129, pp. 572 - 579, http://dx.doi.org/10.1017/S0022215115001164

Chan LJ; Tan L; Dhaliwal J; Briglia F; Clarkson C; Krishnan U, 2015, 'Treatment outcomes for eosinophilic esophagitis in children with esophageal atresia', Diseases of the Esophagus, http://dx.doi.org/10.1111/dote.12368

Shah R; Varjavandi V; Krishnan U, 2015, 'Predictive factors for complications in children with esophageal atresia and tracheoesophageal fistula', Diseases of the Esophagus, vol. 28, pp. 216 - 223, http://dx.doi.org/10.1111/dote.12177

Dhaliwal J; Tobias V; Sugo E; Varjavandi V; Lemberg D; Day A; Bohane T; Ledder O; Jiwane A; Adams S, 2014, 'Eosinophilic esophagitis in children with esophageal atresia', Diseases of the Esophagus, vol. 27, pp. 340 - 347, http://dx.doi.org/10.1111/dote.12119

Dhaliwal J; Lemberg D; Day A; Bohane T; Ledder O; Krishnan U; Tobias V; Sugo E; Shi E; Varjavandi V, 2013, 'Eosinophilic esophagitis in children with eosophageal atresia', Diseases of the Esophagus, http://dx.doi.org/10.1111/dote.12119

Liu R; Jiwane A; Varjavandi A; Kennedy A; Henry G; Dilley A; Currie B; Adams S; Krishnan U, 2013, 'Comparison of percutaneous endoscopic, laparoscopic and open gastrostomy insertion in children', Pediatric Surgery International, vol. 29, pp. 613 - 621, http://dx.doi.org/10.1007/s00383-013-3313-9

Doumit M; Krishnan U; Jaffé A; Belessis Y, 2012, 'Acid and non-acid reflux during physiotherapy in young children with cystic fibrosis', Pediatric Pulmonology, vol. 47, pp. 119 - 124, http://dx.doi.org/10.1002/ppul.21524

Krishnan U; Mitchell JD; Messina I; Day AS; Bohane TD, 2002, 'Assay of tracheal pepsin as a marker of reflux aspiration', JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol. 35, pp. 303 - 308, http://dx.doi.org/10.1097/01.MPG.0000025386.13337.DB

Krishnan U; Mitchell JD; Tobias V; Day AS; Bohane TD, 2002, 'Fat laden macrophages in tracheal aspirates as a marker of reflux aspiration: A negative report', JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol. 35, pp. 309 - 313, http://dx.doi.org/10.1097/01.MPG.0000025358.04164.61

Krishnan U; Mitchell JD; Messina I; Day AS; Bohane TD, 2002, 'Assay of tracheal pepsin as a marker of reflux aspiration', Journal of Pediatric Gastroenterology and Nutrition, vol. 35, pp. 303 - 308, http://dx.doi.org/10.1097/00005176-200209000-00012

Krishnan U; Mitchell JD; Tobias V; Day AS; Bohane TD, 2002, 'Fat laden macrophages in tracheal aspirates as a marker of reflux aspiration: A negative report', Journal of Pediatric Gastroenterology and Nutrition, vol. 35, pp. 309 - 313, http://dx.doi.org/10.1097/00005176-200209000-00013

Conference Papers

Webb N; Jiwane A; Oei K; Nightinghale S; Adams S; Krishnan U, 2015, 'Clinical significance of liver histology on outcomes in biliary atresia', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, pp. 171 - 171, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900328&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Pascoe E; Falvey T; Jiwane A; Henry G; Krishnan U, 2015, 'Outcomes of Fundoplication for Paediatric Gastro-Oesophageal Reflux Disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, pp. 168 - 169, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900324&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Presentations

Ooi CY; Jeyaruban C; Katz T; Matson A; Bell SC; Adams SE; Krishnan U, 2014, 'HIGH AMBIENT TEMPERATURE IS A RISK FACTOR FOR DISTAL INTESTINAL OBSTRUCTIVE SYNDROME AND CONSTIPATION IN CHILDREN WITH CYSTIC FIBROSIS', in PEDIATRIC PULMONOLOGY, WILEY-BLACKWELL, Vol. 49, pp. 410 - 410, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342926000613&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

School of Women's and Children's Health

Dr Usha Krishnan

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