Dr Usha Krishnan

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Discipline:

Paediatrics

Dr Usha Krishnan is a Senior Lecturer with the School of Women's & Children's Health. She is also the director of the only paediatric motility service and dedicated multidisciplinary oesophageal atresia-tracheoesophageal fistula clinic in the state. Her research interests lies in childhood motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease and reflux aspiration, growth and nutrition, eosinophilic esophagitis, gut microbiome and oesophageal atresia.

School:

Sch Women's&Children's Health

University role:

Senior Staff Specialist in Paediatric Gastroenterology, Director of Motility Services, Director of Oesophageal Atresia-Tracheoesophageal Fistula Clinic

Qualifications:

MBBS; FRACP

Grants:

European Society for Pediatric Gastroenterology Hepatology and Nutrition Networking Grant 2017

Research

Research activities:

1. Eosinophilic esophagitis in Esophageal Atresia

2. Gastrointestinal and nutritional complications in children with Oesophageal Atresia

3. Oesophageal microbiome and risk for Barretts Esophagua in Oesophageal Atresia

4. Stool microbiome in Oesophageal Atresia

5. Role of multichannel impedance monitoring in children with gastroesophageal reflux disease

5. Gastric function in Oesophageal Atresia.

6. Role of pepsin as a biomarker of reflux aspiration

Socio-economic Objective (SEO) tags:

Child Health

Field of Research (FOR) Tag:

Paediatrics

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

ILP and ILP (Honours) Students in 2019

Research Areas of interest:

•1.Gastrointestinal motility disorders

•2. Oesophageal Atresia

•3. Eosinophilic oesophagitis

•4. Gastroesophageal reflux disease and reflux aspiration

•5. Growth and nutrition

Projects Available / Research Areas :

Effect of Ketogenic diet on gastroesophageal reflux, gastric and colonic function, growth and nutrition and quality of life in patients with seizure disorders
. Predictive factors for the prevalence of fungal oesophagitis in children
Increased risk for anaesthetic complications in children with oesophageal atresia
Radiation exposure risk in infants and children with oesophageal atresia
Dietary intake and predictors of malnutrition in children with oesophageal atresia
Effect of blenderised diet on gastric function and microbiome
Nature of Projects / Methodology:

• Quantitative research /Prospective study using symptom questionnaire and hands on clinical motility studies

–Effect of Ketogenic diet on gastroesophageal reflux, gastric and colonic function, growth and nutrition and quality of life in patients with seizure disorders

–

• Quantitative research /Prospective study using symptom questionnaire and hands on laboratory work

–Effect of blenderised diet on gastric function and microbiome

•Prospective study with patient contact and using validated questionnaires

–Dietary intake and predictors of malnutrition in children with oesophageal atresia

•Retrospective chart reviews

–Predictive factors for the prevalence of fungal oesophagitis in children

–Increased risk for anaesthetic complications in children with oesophageal atresia

–Radiation exposure risk in infants and children with oesophageal atresia

Clinical Exposure

–Students will be invited to attend clinics with the supervisor and take part in departmental journal club, academic meetings, histopathology and radiology meeting, observing endoscopy procedures in operating theatres

–Students will be encouraged to write up their ILP project for publication in a peer reviewed journal and presentation in national and international conferences
Location of projects:

Sydney Children’s Hospital

Contact Details:

Dr Usha Krishnan

Usha.krishnan@health.nsw.gov.au

(02) 93821752

Currently supervising:

ILP Projects:

1. Does reflux monitoring with multichannel intraluminal impedance affect clinical outcomes in children with gastroesophageal reflux disease (GORD)?

2. Biliary Atresia and Neonatal Cholestasis in neonates

Publications related to this Person

Journal articles

Omari TI; Krishnan U, 2020, 'What is the role of high-resolution oesophageal manometry in paediatrics?', Journal of Paediatrics and Child Health, vol. 56, pp. 1754 - 1759, http://dx.doi.org/10.1111/jpc.15057

Ledder O; Duvoisin G; Lekar M; Lopez RN; Singh H; Dehlsen K; Lev-Tzion R; Orlanski-Meyer E; Shteyer E; Krishnan U; Gupta N; Lemberg DA; Cohen S; Ooi CY, 2020, 'Early feeding in acute pancreatitis in children: A randomized controlled trial', Pediatrics, vol. 146, http://dx.doi.org/10.1542/PEDS.2020-1149

Ting A; Katz T; Sutherland R; Liu V; Tong CW; Gao Y; Lemberg DA; Krishnan U; Gupta N; Coffey MJ; Ooi CY, 2020, 'Evaluating the Dietary Intakes of Energy, Macronutrients, Sugar, Fiber, and Micronutrients in Children With Celiac Disease', Journal of pediatric gastroenterology and nutrition, vol. 71, pp. 246 - 251, http://dx.doi.org/10.1097/MPG.0000000000002743

Zeevenhooven J; Rexwinkel R; Van Berge Henegouwen VWA; Krishnan U; Vandenplas Y; Strisciuglio C; Staiano A; Devanarayana NM; Rajindrajith S; Benninga MA; Tabbers MM, 2020, 'A Core Outcome Set for Clinical Trials in Pediatric Functional Abdominal Pain Disorders', Journal of Pediatrics, vol. 221, pp. 115 - 122.e5, http://dx.doi.org/10.1016/j.jpeds.2020.02.032

Traini I; Menzies J; Hughes J; Leach ST; Krishnan U, 2020, 'Oesophageal atresia: The growth gap', World Journal of Gastroenterology, vol. 26, pp. 1262 - 1272, http://dx.doi.org/10.3748/WJG.V26.I12.1262

Upendran Y; Leach ST; Singh H; McBride J; Thomas PS; Belessis Y; Krishnan U, 2020, 'Pepsin as a Marker of Reflux Aspiration in Children With Esophageal Atresia: A Pilot Study', Frontiers in Pediatrics, vol. 8, http://dx.doi.org/10.3389/fped.2020.00094

Chandrasekar N; Dehlsen K; Leach ST; Krishnan U, 2020, 'Exploring Clinical Outcomes and Feasibility of Blended Tube Feeds in Children', Journal of Parenteral and Enteral Nutrition, http://dx.doi.org/10.1002/jpen.2062

Krishnan U, 2019, 'Eosinophilic Esophagitis in Esophageal Atresia', Frontiers in Pediatrics, vol. 7, http://dx.doi.org/10.3389/fped.2019.00497

Singh H; Weber MA; Low J; Krishnan U, 2019, 'Sarcina in an Adolescent with Repaired Esophageal Atresia: A Pathogen or a Benign Commensal?', Journal of Pediatric Gastroenterology and Nutrition, vol. 69, pp. e57, http://dx.doi.org/10.1097/MPG.0000000000002339

Rosen RL; Krishnan U; Mousa H; Dall'oglio L; Faure C; Gottrand F, 2018, 'The case for thoughtful prescribing of proton pump inhibitors in infants', Journal of Pediatric Gastroenterology and Nutrition, vol. 66, pp. e26 - e27, http://dx.doi.org/10.1097/MPG.0000000000001794

Krishnan U; Lijuan C; Gifford A; Rothenberg ME; Wen T, 2018, 'Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia', Journal of Allergy and Clinical Immunology, http://dx.doi.org/10.1016/j.jaci.2018.08.040

Mousa H; Krishnan U; Hassan M; Dall’Oglio L; Rosen R; Gottrand F; Faure C, 2017, 'How to Care for Patients with EA-TEF: The Known and the Unknown', Current Gastroenterology Reports, vol. 19, http://dx.doi.org/10.1007/s11894-017-0605-6

Krishnan U; Faure C, 2017, 'Editorial: Oesophageal atresia-tracheoesophageal fistula', Frontiers in Pediatrics, vol. 5, http://dx.doi.org/10.3389/fped.2017.00190

Wanaguru D; Langusch C; Krishnan U; Varjavandi V; Jiwane A; Adams S; Henry G, 2017, 'Is fundoplication required after the Foker procedure for long gap esophageal atresia?', Journal of Pediatric Surgery, vol. 52, pp. 1117 - 1120, http://dx.doi.org/10.1016/j.jpedsurg.2016.12.014

Pilli S; Jiwane A; Krishnan U, 2017, 'Quality of life in children who have undergone fundoplication surgery for the treatment of gastroesophageal reflux disease: A review of literature', Diseases of the Esophagus, vol. 30, http://dx.doi.org/10.1093/dote/dow017

Duvoisin G; Krishnan U, 2017, 'Gastric function in children with oesophageal atresia and tracheoesophageal fistula', Frontiers in Pediatrics, vol. 5, http://dx.doi.org/10.3389/fped.2017.00076

Alhagamhmad MH; Lemberg DA; Day AS; Tan LZ; Ooi CY; Krishnan U; Gupta N; Munday JS; Leach ST, 2017, 'Advancing nutritional therapy: A novel polymeric formulation attenuates intestinal inflammation in a murine colitis model and suppresses pro-inflammatory cytokine production in ex-vivo cultured inflamed colonic biopsies', Clinical Nutrition, vol. 36, pp. 497 - 505, http://dx.doi.org/10.1016/j.clnu.2016.01.010

Menzies J; Hughes J; Leach S; Belessis Y; Krishnan U, 2017, 'Prevalence of malnutrition and feeding difficulties in children with esophageal atresia', Journal of Pediatric Gastroenterology and Nutrition, vol. 64, pp. e100 - e105, http://dx.doi.org/10.1097/MPG.0000000000001436

Bowden MR; Ee LC; Krishnan U; O'Loughlin EV; Hardikar W; Carmody D; Hainsworth C; Jermyn V; Lee MM; Sawyer J; Stormon M; Holmes K; Lemberg DA; Day AS; Paul C; Hazell P, 2017, 'Family impact and infant emotional outcomes following diagnosis of serious liver disease or transplantation in infancy', Journal of Pediatric Gastroenterology and Nutrition, vol. 64, pp. 528 - 532, http://dx.doi.org/10.1097/MPG.0000000000001404

Lopez RN; Ooi CY; Krishnan U, 2017, 'Early and Peri-operative Prognostic Indicators in Infants Undergoing Hepatic Portoenterostomy for Biliary Atresia: a Review', Current Gastroenterology Reports, vol. 19, http://dx.doi.org/10.1007/s11894-017-0555-z

Webb NL; Jiwane A; Ooi CY; Nightinghale S; Adams SE; Krishnan U, 2017, 'Clinical significance of liver histology on outcomes in biliary atresia', Journal of Paediatrics and Child Health, vol. 53, pp. 252 - 256, http://dx.doi.org/10.1111/jpc.13371

Lopez RN; Krishnan U; Ooi CY, 2017, 'Enteritis with pneumatosis intestinalis following rotavirus immunisation in an infant with short bowel syndrome', BMJ Case Reports, vol. 2017, http://dx.doi.org/10.1136/bcr-2017-219482

Tong S; Mallitt KA; Krishnan U, 2016, 'Evaluation of Gastroesophageal Reflux by Combined Multichannel Intraluminal Impedance and pH Monitoring and Esophageal Motility Patterns in Children with Esophageal Atresia', European Journal of Pediatric Surgery, vol. 26, pp. 322 - 331, http://dx.doi.org/10.1055/s-0035-1564715

Chan LJ; Tan L; Dhaliwal J; Briglia F; Clarkson C; Krishnan U, 2016, 'Treatment outcomes for eosinophilic esophagitis in children with esophageal atresia', Diseases of the Esophagus, vol. 29, pp. 563 - 571, http://dx.doi.org/10.1111/dote.12368

Pascoe E; Falvey T; Jiwane A; Henry G; Krishnan U, 2016, 'Outcomes of fundoplication for paediatric gastroesophageal reflux disease', Pediatric Surgery International, vol. 32, pp. 353 - 361, http://dx.doi.org/10.1007/s00383-015-3843-4

Ooi CY; Jeyaruban C; Lau J; Katz T; Matson A; Bell SC; Adams SE; Krishnan U, 2016, 'High ambient temperature and risk of intestinal obstruction in cystic fibrosis', Journal of Paediatrics and Child Health, vol. 52, pp. 430 - 435, http://dx.doi.org/10.1111/jpc.13096

Safe M; Cho J; Krishnan U, 2016, 'Combined multichannel intraluminal impedance and pH measurement in detecting gastroesophageal reflux disease in children', Journal of Pediatric Gastroenterology and Nutrition, vol. 63, pp. e98 - e106, http://dx.doi.org/10.1097/MPG.0000000000001396

Krishnan U; Mousa H; Dall'Oglio L; Homaira N; Rosen R; Faure C; Gottrand F, 2016, 'ESPGHAN-NASPGHAN guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with esophageal atresia-tracheoesophageal fistula', Journal of Pediatric Gastroenterology and Nutrition, vol. 63, pp. 550 - 570, http://dx.doi.org/10.1097/MPG.0000000000001401

Pascoe E; Falvey T; Jiwane A; Henry G; Krishnan U, 2015, 'Outcomes of fundoplication for paediatric gastroesophageal reflux disease', Pediatric Surgery International, pp. 1 - 9, http://dx.doi.org/10.1007/s00383-015-3843-4

Tan LZ; Gifford AJ; Clarkson CM; Henry GM; Krishnan U, 2015, 'Barrett's esophagus and eosinophilic esophagitis in a young pediatric patient with esophageal atresia', Journal of Pediatric Surgery Case Reports, vol. 3, pp. 272 - 275, http://dx.doi.org/10.1016/j.epsc.2015.05.004

Shah R; Varjavandi V; Krishnan U, 2015, 'Predictive factors for complications in children with esophageal atresia and tracheoesophageal fistula', Diseases of the Esophagus, vol. 28, pp. 216 - 223, http://dx.doi.org/10.1111/dote.12177

Chan LJ; Tan L; Dhaliwal J; Briglia F; Clarkson C; Krishnan U, 2015, 'Treatment outcomes for eosinophilic esophagitis in children with esophageal atresia', Diseases of the Esophagus, http://dx.doi.org/10.1111/dote.12368

Krishnan U; Paul S; Messina I; Soma M, 2015, 'Correlation between laryngobronchoscopy and pepsin in the diagnosis of extra-oesophageal reflux', Journal of Laryngology and Otology, vol. 129, pp. 572 - 579, http://dx.doi.org/10.1017/S0022215115001164

Bowden MR; Stormon M; Hardikar W; Ee LC; Krishnan U; Carmody D; Jermyn V; Lee MM; O'Loughlin EV; Sawyer J; Beyerle K; Lemberg DA; Day AS; Paul C; Hazell P, 2015, 'Family adjustment and parenting stress when an infant has serious liver disease: The Australian experience', Journal of Pediatric Gastroenterology and Nutrition, vol. 60, pp. 717 - 722, http://dx.doi.org/10.1097/MPG.0000000000000742

Dhaliwal J; Tobias V; Sugo E; Varjavandi V; Lemberg D; Day A; Bohane T; Ledder O; Jiwane A; Adams S; Henry G; Dilley A; Shi E; Krishnan U, 2014, 'Eosinophilic esophagitis in children with esophageal atresia', Diseases of the Esophagus, vol. 27, pp. 340 - 347, http://dx.doi.org/10.1111/dote.12119

Liu R; Jiwane A; Varjavandi A; Kennedy A; Henry G; Dilley A; Currie B; Adams S; Krishnan U, 2013, 'Comparison of percutaneous endoscopic, laparoscopic and open gastrostomy insertion in children', Pediatric Surgery International, vol. 29, pp. 613 - 621, http://dx.doi.org/10.1007/s00383-013-3313-9

Dhaliwal J; Lemberg D; Day A; Bohane T; Ledder O; Krishnan U; Tobias V; Sugo E; Shi E; Varjavandi V; Jiwane A; Adams S; Henry G; Dilley A, 2013, 'Eosinophilic esophagitis in children with eosophageal atresia', Diseases of the Esophagus, http://dx.doi.org/10.1111/dote.12119

Doumit M; Krishnan U; Jaffe A; Belessis Y, 2012, 'Acid and non-acid reflux during physiotherapy in young children with cystic fibrosis', Pediatric Pulmonology, vol. 47, pp. 119 - 124, http://dx.doi.org/10.1002/ppul.21524

Krishnan U; Mitchell JD; Tobias V; Day AS; Bohane TD, 2002, 'Fat laden macrophages in tracheal aspirates as a marker of reflux aspiration: A negative report', JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol. 35, pp. 309 - 313, http://dx.doi.org/10.1097/00005176-200209000-00013

Krishnan U; Mitchell JD; Messina I; Day AS; Bohane TD, 2002, 'Assay of tracheal pepsin as a marker of reflux aspiration', JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol. 35, pp. 303 - 308, http://dx.doi.org/10.1097/00005176-200209000-00012

Krisnan U; mitchell JD; Tobias VH; Day AS; Bohane TD, 2002, 'Fat Laden Macrophages in Tracheal Aspirates as a Marker of Reflux Aspiration: A Negative Report', Journal of Pediatric Gastroenterology and Nutrition, vol. 35, pp. 309 - 313, http://dx.doi.org/10.1097/00005176-200209000-00013

Krisnan U; mitchell JD; Messina I; Day AS; Bohane TD, 2002, 'Assay of Tracheal Pepsin as a Marker of Reflux Aspiration', Journal of Pediatric Gastroenterology and Nutrition, vol. 35, pp. 303 - 308, http://dx.doi.org/10.1097/00005176-200209000-00012

Conference Papers

Pascoe E; Falvey T; Jiwane A; Henry G; Krishnan U, 2015, 'Outcomes of Fundoplication for Paediatric Gastro-Oesophageal Reflux Disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, pp. 168 - 169, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900324&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Webb N; Jiwane A; Oei K; Nightinghale S; Adams S; Krishnan U, 2015, 'Clinical significance of liver histology on outcomes in biliary atresia', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, pp. 171 - 171, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364505900328&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Presentations

Ooi CY; Jeyaruban C; Katz T; Matson A; Bell SC; Adams SE; Krishnan U, 2014, 'HIGH AMBIENT TEMPERATURE IS A RISK FACTOR FOR DISTAL INTESTINAL OBSTRUCTIVE SYNDROME AND CONSTIPATION IN CHILDREN WITH CYSTIC FIBROSIS', in PEDIATRIC PULMONOLOGY, WILEY-BLACKWELL, Vol. 49, pp. 410 - 410, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342926000613&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

O'Donnell JEM; Purcell M; Mousa H; Dall'oglio L; Rosen R; Faure C; Gottrand F; Krishnan U, 2020, 'Clinician awareness and understanding of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition-North American Society for Pediatric Gastroenterology, Hepatology and Nutrition guidelines on management of gastrointestinal complications in esophageal atresia', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 35, pp. 196 - 196, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589476200291&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Traini I; Menzies J; Hughes J; Katz T; Coffey MJ; Ooi CY; Leach ST; Krishnan U, 2020, 'LOOKING BEYOND THE ESOPHAGUS: INVESTIGATING THE INTESTINAL MICROBIOTA AND INFLAMMATION IN CHILDREN WITH REPAIRED ESOPHAGEAL ATRESIA', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Austin, TX, Vol. 158, pp. S1507 - S1508, presented at Crohn's and Colitis Congress, Austin, TX, 23 January 2020 - 25 January 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000540349505031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Traini I; Menzies J; Hughes J; Katz T; Coffey MJ; Ooi CY; Leach ST; Krishnan U, 2020, 'FOOD FOR THOUGHT: DIET, DYSPHAGIA AND GROWTH IN CHILDREN WITH REPAIRED ESOPHAGEAL ATRESIA', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Austin, TX, Vol. 158, pp. S1575 - S1575, presented at Crohn's and Colitis Congress, Austin, TX, 23 January 2020 - 25 January 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000540349505211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yadhavan Upendran Y; Leach S; Thomas P; Dettmer P; Duvoisin G; McBride J; Belessis Y; Krishnan U, 2016, 'Exhaled breath condensate & salivary pepsin as non-invasive markers of reflux aspiration in children with oesophageal atresia and tracheo-oesophageal fistula', in Exhaled breath condensate & salivary pepsin as non-invasive markers of reflux aspiration in children with oesophageal atresia and tracheo-oesophageal fistula, · Diseases of the Esophagus, Sydney, Australia, presented at 4th International Conference on Oesophageal Atresia, Sydney, Australia, 15 September 2016, http://dx.doi.org/10.3389/conf.FPED.2017.01.000013

School of Women's and Children's Health

Dr Usha Krishnan

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