Professor Robert Gilchrist

Tabs

Main

Contact Category:

Academic

Discipline:

Obstetrics & Gynaecology

Qualifications: B.Rur.Sc. (Hons), M.Sc.Agr, D.Sc.Agr.(Gott), FSRB

Professor Robert Gilchrist is an NHMRC Senior Research Fellow and Director of Research in the School of Women's & Children's Health. He is a translational research scientist, specialising in oocyte and reproductive biology and is an international leader in oocyte-somatic cell communication, with prominent clinical and commercial activities.

Background: Dr Gilchrist completed his D.Sc.Agr. (Magna cum laude) in 1996 on oocyte maturation at the University of Göttingen in Germany, and then returned to Australia to take up a post-doctoral position at the University of Adelaide. In 2014 he was recruited to UNSW through the Vice Chancellor’s Strategic Priority Fund (SPF01) and is currently the Director of the Oocyte Biology Research Unit.

Discovery Research: Prof Gilchrist’s research underpins a new paradigm in ovarian biology: the oocyte is not passive, but instead actively regulates the differentiation of its neighbouring somatic cells through the secretion of paracrine growth factors; GDF9 and BMP15. These growth factors are unusual within the TGFb superfamily and Dr Gilchrist has pioneered the cell biology of this paracrine signalling axis. This axis impacts on oocyte developmental competence and later embryo/fetal growth, ovarian disease and fertility. His second major area of discovery research relates to somatic (cumulus) cell control of oocyte function. This encompasses understanding cumulus cell-oocyte gap junctional communication and somatic cell control of oocyte function through the exchange of small regulatory molecules such as cAMP. This profoundly impacts oocyte meiosis and subsequent embryo developmental potential.

Translational Research: Dr Gilchrist is passionate about translating his research into clinical practice and industry. He is recognised internationally for novel approaches to the treatment of infertility, particularly in the area of oocyte in vitro maturation (IVM), which is an approach that reduces/eliminates drugs from IVF. Prof Gilchrist has generated considerable know-how and intellectual property; notably he is a lead inventor on a family of patents that have been awarded or are in final examination phase in 23 countries, and which have been licensed to Cook Medical, an international manufacturer of products for human assisted reproduction. One of these inventions is undergoing submission to the FDA in August 2014 and other patented technologies are in current international pre-clinical trials which he leads scientifically. In 2009 he co-established a business unit: Prof Gilchrist was the Co-Director of IVF Vet Solutions, a University of Adelaide business unit servicing the human and animal assisted reproductive technology sectors. He was also contracted by the NZ Ministry of Health to report on “The Safety & Efficacy of IVM”.

Publications: Prof Gilchrist currently has 113 peer-reviewed publications, including 21 invited reviews/chapters, plus 1 government commissioned report and 151 abstracts. He currently has an H-index of 39 [Scopus] or 46 [Google Scholar] with >5,200 [Scopus] or >7,700 [Google Scholar] total citations. He has a Field weighted citation impact (FWCI) of 2.35 (SciVal). He publishes in the top-ranking journals in the disciplines of Reproductive Biology and Reproductive Medicine; Human Reproduction Update (3 reviews), Biology of Reproduction (20 papers), Human Reproduction (8 papers), as well as in cross-discipline journals such as in the Proceedings of the National Academy of Science (1 paper), Endocrinology group (9 papers), Journal of Cell Science (3 papers) and Developmental Biology (4 papers), Journal of Biological Chemistry (1 paper).

International & National Profile: Dr Gilchrist is a prominent international and national speaker having received 60 invitations to give plenary/symposia/keynote presentations; at 21 national and 39 international conferences. In addition he has given 22 conference oral presentations (11 overseas, 11 Australia) and 17 guest lectures at institutes (10 overseas, 7 Australia). In 2006 he won the European Society for Human Reproduction and Embryology’s Established Scientist Award and in 2009 the Award for Excellence in Reproductive Biology from the Society for Reproductive Biology. In 2013 he was made a Fellow of the Society for Reproductive Biology.

Funding: Prof Gilchrist has a strong track record of category 1 competitive grant funding: $4.6 million as CIA, plus commercial funding worth $1.4 million as CIA/B. These include: five NHMRC Project Grants as CIA, two NHMRC Development Project Grants as CIA, six Project Grants as Co-CI, an investigator on two NHMRC Program Grants and a NIH Grant, and an ARC Linkage Grant as CIA. As an early career researcher, Prof Gilchrist was awarded the University of Adelaide’s FTT Fricker Medical Research Associateship and then a NHMRC Career Development Award (RD Wright Fellowship). Current grants:

1. NHMRC Senior Research Fellowship APP1023210; RB Gilchrist. Oocyte biology informing new clinical practice. 2012-16.
2. NHMRC Project Grant GNT1062762; RB Gilchrist, J Smitz, JG Thompson, DG Mottershead. EGF peptide signalling improves oocyte maturation and quality. 2014-16.
3. NHMRC Development Grant GNT1076004; RB Gilchrist, J Smitz, JG Thompson, DG Mottershead. Integration of IVM technologies for hormone-free infertility treatment. 2014-16.
4. NHMRC Project Grant APP1024358; C Harrison, D Robertson, KP McNatty, RB Gilchrist. Activation of GDF9 regulates human folliculogenesis. 2012-14.
5. NHMRC Project Grant GNT1067079; DL Russell, RB Gilchrist, Robker R. Manipulating ovarian follicle-oocyte communication to control reproductive outcomes. 2014-16
6. NHMRC Project Grant APP1078134; H Homer, RB Gilchrist, J Carroll, WL Ledger. A BubR1-centred network for non-invasively measuring human oocyte quality. 2015-2017

Training: Over his career he has supervised; 14 research Honours students, 16 PhD/Masters students to completion, and 15 early/senior research fellows. In 2012 he was awarded the School of Paediatrics and Reproductive Health’s (University of Adelaide) Excellence in Post-Graduate Supervision (HDR/Honours) Award.

Professional Contributions: Prof Gilchrist currently sits on the NHMRC Career Development Fellowship Peer Review Panel. He was on the Scientific Advisory Board (2004-10) of the ARC Centre of Excellence in Biotechnology and Development, the Repromed Scientific Advisory Board (2007-12), the Scientific Advisory Board for Fertility SA (2012-13), the executive of the Australian Centre for Perinatal Science (2014-15), and is currently on the Scientific Advisory Board for IVF Australia (2015-curr). Prof Gilchrist was an Associate Editor of Molecular Human Reproduction in 2012. He is a past Council member and Secretary of the Society for Reproductive Biology, and was Chair of the society’s Local Organising Committee for the annual national scientific conference (2009).

Student and Visiting Scientist Mentoring: Prof Gilchrist and his team of scientists welcome Honours, ILP, PhD and overseas Visiting Scholars and will supervise projects in the following areas:

Oocyte-Cumulus Cell Interactions
A principal interest is understanding the dynamic cellular interactions between the oocyte and its neighbouring somatic cells the cumulus cells, and the significance of this interaction on the quality of the oocyte and resultant embryo. His research has contributed significantly to the concept that the oocyte actively regulates the differentiation and function of cumulus cells through the secretion of soluble paracrine factors. Conversely, cumulus cells nurture the growth and maturation of the oocyte by various means including via gap-junctions. He is interested in mechanisms regulating oocyte-cumulus cell gap-junctional communication.

Oocyte GDF9 and BMP15 Paracrine Signalling
Dr Gilchrist’s group investigates the molecular nature of the key oocyte paracrine signalling molecules GDF9 and BMP15. This includes; production of novel forms of recombinant GDF9/BMP15, cellular mechanism regulating oocyte secretion of these growth factors, and intracellular consequences in cumulus cells (SMAD and MAPK signalling).

Regulation of Oocyte Meiosis
His group is actively investigating the cellular mechanisms regulating oocyte meiotic arrest and resumption. This work focuses on the roles of cAMP and phosphodiesterases in the oocyte and cumulus cells and their regulation of oocyte maturation, particularly in an in vitro maturation (IVM) context.

Oocyte In Vitro Maturation (IVM) Systems for Novel Reproductive Technologies
Dr Gilchrist is particularly active in the application of knowledge of cumulus-oocyte biology in the development of new oocyte IVM systems. The objective of this applied research program is to improve the developmental potential of IVM oocytes to provide new opportunities in human infertility treatment and in domestic animal advanced artificial breeding programs. New IVM systems in development include the use of exogenous GDF9/BMP15 during IVM and the on-going refinement of a new approach to IVM called SPOM (Simulated Physiological Oocyte Maturation). Human and veterinary pre-clinical trials are currently being conducted with end-user partners.

School:

Discip Obstetrics&Gynaecology

Phone:

(02) 9385 2562

Email:

r.gilchrist@unsw.edu.au

University role:

Professor & NHMRC Senior Research Fellow

Research

Socio-economic Objective (SEO) tags:

Women's Health

Reproductive System and Disorders

Field of Research (FOR) Tag:

Obstetrics and Gynaecology

Reproduction

Fertility

Media

Twitter Account:

https://twitter.com/RG_EggLab

Publications related to this Person

Book Chapters

Findlay J; Dunning K; Gilchrist R; Hutt K; Russell D; Walters K, 2018, 'Follicle selection in mammalian ovaries', in The Ovary, Academic Press, London, England, pp. 3 - 21, https://www.elsevier.com/books/the-ovary/leung/978-0-12-813209-8

Thompson JT; Gilchrist RB; Sutton--McDowall ML, 2014, 'The metabolism of the ruminant cumulus-oocyte complex revisited', in Juengel JL; Miyamoto A; Price C (ed.), Reproduction in Domestic Ruminants VIII Proceedings of the Ninth International Symposium on Reproduction in Domestic Ruminants, Context Products, Leicestershire, UK, pp. 311 - 326

Thompson JG; Gilchrist RB, 2013, 'Improving oocyte maturation in vitro', in Trounson A; Gosden R; Eichenlaub-Ritter U (ed.), Biology and Pathology of the Oocyte, Cambridge University Press, pp. 212 - 223, http://dx.doi.org/10.1017/CBO9781139135030.019

Thompson JG; Mottershead DG; Gilchrist RB, 2013, 'Oocyte-secreted factors in domestic animals', in Krisher R (ed.), Oocyte Physiology and Development in Domestic Animals, John Wiley & Sons, pp. 55 - 70

Gilchrist RB; Smitz JEJ; Thompson JG, 2011, 'Current status and future trends of the clinical practice of human oocyte in vitro maturation', in Gardner DK; Rizk BRMB; Falcone T (ed.), Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice, Cambridge University Press, pp. 186 - 198, http://dx.doi.org/10.1017/CBO9780511734755.018

Journal articles

Stocker WA; Walton KL; Richani D; Chan KL; Beilby KH; Finger BJ; Green MP; Gilchrist RB; Harrison CA, 2020, 'A variant of human growth differentiation factor-9 that improves oocyte developmental competence', Journal of Biological Chemistry, vol. 295, pp. 7981 - 7991, http://dx.doi.org/10.1074/JBC.RA120.013050

Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD⁺ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, vol. 30, pp. 1670 - 1681.e7, http://dx.doi.org/10.1016/j.celrep.2020.01.058

Vuong LN; Le AH; Ho VNA; Pham TD; Sanchez F; Romero S; De Vos M; Ho TM; Gilchrist RB; Smitz J, 2020, 'Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome', Journal of Assisted Reproduction and Genetics, vol. 37, pp. 347 - 357, http://dx.doi.org/10.1007/s10815-019-01677-6

Zhao Y; Liao X; Krysta AE; Bertoldo MJ; Richani D; Gilchrist RB, 2020, 'Capacitation IVM improves cumulus function and oocyte quality in minimally stimulated mice', Journal of Assisted Reproduction and Genetics, vol. 37, pp. 77 - 88, http://dx.doi.org/10.1007/s10815-019-01610-x

Anderson RA; Gilchrist RB, 2020, 'Autoimmune ovarian insufficiency: broadening indications for in vitro maturation', Fertility and Sterility, http://dx.doi.org/10.1016/j.fertnstert.2020.05.024

Richani D; Lavea CF; Kanakkaparambil R; Riepsamen AH; Bertoldo MJ; Bustamante S; Gilchrist RB, 2019, 'Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism', Scientific Reports, vol. 9, pp. 18395, http://dx.doi.org/10.1038/s41598-019-54693-y

Sanchez F; Le AH; Ho VNA; Romero S; Van Ranst H; De Vos M; Gilchrist RB; Ho TM; Vuong LN; Smitz J, 2019, 'Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles', Journal of Assisted Reproduction and Genetics, vol. 36, pp. 2135 - 2144, http://dx.doi.org/10.1007/s10815-019-01551-5

Riepsamen AH; Chan K; Lien S; Sweeten P; Donoghoe MW; Walker G; Fraison EHJ; Stocker WA; Walton KL; Harrison CA; Ledger WL; Robertson DM; Gilchrist RB, 2019, 'Serum Concentrations of Oocyte-Secreted Factors BMP15 and GDF9 during IVF and in Women with Reproductive Pathologies', Endocrinology, vol. 160, pp. 2298 - 2313, http://dx.doi.org/10.1210/en.2019-00264

Bertoldo MJ; Cheung MY; Sia ZK; Agapiou D; Corley SM; Wilkins MR; Richani D; Harrison CA; Gilchrist RB, 2019, 'Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells', Molecular and Cellular Endocrinology, vol. 490, pp. 37 - 46, http://dx.doi.org/10.1016/j.mce.2019.04.003

Bertoldo MJ; Caldwell ASL; Riepsamen AH; Lin D; Gonzalez MB; Robker RL; Ledger WL; Gilchrist RB; Handelsman DJ; Walters KA, 2019, 'A hyperandrogenic environment causes intrinsic defects that are detrimental to follicular dynamics in a PCOS mouse model', Endocrinology, vol. 160, pp. 699 - 715, http://dx.doi.org/10.1210/en.2018-00966

Richani D; Constance K; Lien S; Agapiou D; Stocker WA; Hedger MP; Ledger WL; Thompson JG; Robertson DM; Mottershead DG; Walton KL; Harrison CA; Gilchrist RB, 2019, 'Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro', Endocrinology, vol. 160, pp. 853 - 862, http://dx.doi.org/10.1210/en.2018-01026

Vuong LN; Ho TM; Gilchrist RB; Smitz J, 2019, 'The Place of In Vitro Maturation in Assisted Reproductive Technology', Fertility & Reproduction, vol. 01, pp. 11 - 15, http://dx.doi.org/10.1142/s2661318219300022

Walters KA; Gilchrist RB; Ledger WL; Teede HJ; Handelsman DJ; Campbell RE, 2018, 'New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins', Trends in Endocrinology and Metabolism, vol. 29, pp. 841 - 852, http://dx.doi.org/10.1016/j.tem.2018.08.005

Vuong LN; Ho VNA; Ho TM; Dang VQ; Phung TH; Giang NH; Le AH; Pham TD; Wang R; Norman RJ; Smitz J; Gilchrist RB; Mol BW, 2018, 'Effectiveness and safety of in vitro maturation of oocytes versus in vitro fertilisation in women with high antral follicle count: Study protocol for a randomised controlled trial', BMJ Open, vol. 8, http://dx.doi.org/10.1136/bmjopen-2018-023413

Bertoldo MJ; Walters KA; Ledger WL; Gilchrist RB; Mermillod P; Locatelli Y, 2018, 'In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies', Reproductive BioMedicine Online, vol. 36, pp. 491 - 499, http://dx.doi.org/10.1016/j.rbmo.2018.01.014

Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, vol. 14, http://dx.doi.org/10.1007/s11306-017-1310-z

Richani D; Gilchrist RB, 2018, 'The epidermal growth factor network: Role in oocyte growth, maturation and developmental competence', Human Reproduction Update, vol. 24, pp. 1 - 14, http://dx.doi.org/10.1093/humupd/dmx029

Sugimura S; Yamanouchi T; Palmerini MG; Hashiyada Y; Imai K; Gilchrist RB, 2018, 'Effect of pre-in vitro maturation with cAMP modulators on the acquisition of oocyte developmental competence in cattle', Journal of Reproduction and Development, vol. 64, pp. 233 - 241, http://dx.doi.org/10.1262/jrd.2018-009

Bertoldo MJ; Uddin GM; Youngson NA; Agapiou D; Walters KA; Sinclair DA; Morris MJ; Gilchrist RB, 2018, 'Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.', Hum Reprod Open, vol. 2018, pp. hoy010 - hoy010, http://dx.doi.org/10.1093/hropen/hoy010

Sugimura S; Kobayashi N; Okae H; Yamanouchi T; Matsuda H; Kojima T; Yajima A; Hashiyada Y; Kaneda M; Sato K; Imai K; Tanemura K; Arima T; Gilchrist RB, 2017, 'Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/s41598-017-07039-5

Bustamante S; Gilchrist RB; Richani D, 2017, 'A sensitive method for the separation and quantification of low-level adenine nucleotides using porous graphitic carbon-based liquid chromatography and tandem mass spectrometry', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1061-1062, pp. 445 - 451, http://dx.doi.org/10.1016/j.jchromb.2017.07.044

Rodgers RJ; Reid GD; Koch J; Deans R; Ledger WL; Friedlander M; Gilchrist RB; Walters KA; Abbott JA, 2017, 'The safety and efficacy of controlled ovarian hyperstimulation for fertility preservation in women with early breast cancer: A systematic review', Human Reproduction, vol. 32, pp. 1033 - 1045, http://dx.doi.org/10.1093/humrep/dex027

Caldwell ASL; Edwards MC; Desai R; Jimenez M; Gilchrist RB; Handelsman DJ; Walters KA, 2017, 'Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. E3334 - E3343, http://dx.doi.org/10.1073/pnas.1616467114

Patino LC; Walton KL; Mueller TD; Johnson KE; Stocker W; Richani D; Agapiou D; Gilchrist RB; Laissue P; Harrison CA, 2017, 'BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with gdf9', Journal of Clinical Endocrinology and Metabolism, vol. 102, pp. 1009 - 1019, http://dx.doi.org/10.1210/jc.2016-3503

Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, vol. 7, http://dx.doi.org/10.1038/srep40159

Brown HM; Dunning KR; Sutton-McDowall M; Gilchrist RB; Thompson JG; Russell DL, 2017, 'Failure to launch: Aberrant cumulus gene expression during oocyte in vitro maturation', Reproduction, vol. 153, pp. R109 - R120, http://dx.doi.org/10.1530/REP-16-0426

Smitz JEJ; Gilchrist RB, 2016, 'Are human oocytes from stem cells next?', Nature Biotechnology, vol. 34, pp. 1247 - 1248, http://dx.doi.org/10.1038/nbt.3742

De Vos M; Smitz J; Thompson JG; Gilchrist RB, 2016, 'The definition of IVM is clear - Variations need defining', Human Reproduction, vol. 31, pp. 2411 - 2415, http://dx.doi.org/10.1093/humrep/dew208

Russell DL; Gilchrist RB; Brown HM; Thompson JG, 2016, 'Bidirectional communication between cumulus cells and the oocyte: Old hands and new players?', Theriogenology, vol. 86, pp. 62 - 68, http://dx.doi.org/10.1016/j.theriogenology.2016.04.019

Wang X; Gook DA; Walters KA; Anazodo A; Ledger WL; Gilchrist RB, 2016, 'Improving fertility preservation for girls and women by coupling oocyte in vitro maturation with existing strategies', Women's Health, vol. 12, pp. 275 - 278, http://dx.doi.org/10.2217/whe-2016-0019

Robertson DM; Gilchrist RB; Ledger WL; Baerwald A, 2016, 'Random start or emergency IVF/in vitro maturation: A new rapid approach to fertility preservation', Women's Health, vol. 12, pp. 339 - 349, http://dx.doi.org/10.2217/whe-2015-0001

Li HJ; Sutton-Mcdowall ML; Wang X; Sugimura S; Thompson JG; Gilchrist RB, 2016, 'Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions', Human Reproduction, vol. 31, pp. 810 - 821, http://dx.doi.org/10.1093/humrep/dew020

Reader KL; Mottershead DG; Martin GA; Gilchrist RB; Heath DA; McNatty KP; Juengel JL, 2016, 'Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15', Reproduction, Fertility and Development, vol. 28, pp. 491 - 498, http://dx.doi.org/10.1071/RD14099

Gilchrist RB; Luciano AM; Richani D; Zeng HT; Wang X; De Vos M; Sugimura S; Smitz J; Richard FJ; Thompson JG, 2016, 'Oocyte maturation and quality: Role of cyclic nucleotides', Reproduction, vol. 152, pp. R143 - R157, http://dx.doi.org/10.1530/REP-15-0606

Mottershead DG; Sugimura S; Al-Musawi SL; Li JJ; Richani D; White MA; Martin GA; Trotta AP; Ritter LJ; Shi J; Mueller TD; Harrison CA; Gilchrist RB, 2015, 'Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-β family, is a potent activator of granulosa cells and improves oocyte quality', Journal of Biological Chemistry, vol. 290, pp. 24007 - 24020, http://dx.doi.org/10.1074/jbc.M115.671487

Sugimura S; Ritter LJ; Rose RD; Thompson JG; Smitz J; Mottershead DG; Gilchrist RB, 2015, 'Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes', Developmental Biology, vol. 403, pp. 139 - 149, http://dx.doi.org/10.1016/j.ydbio.2015.05.008

Ritter LJ; Sugimura S; Gilchrist RB, 2015, 'Oocyte induction of EGF responsiveness in somatic cells is associated with the acquisition of porcine oocyte developmental competence', Endocrinology, vol. 156, pp. 2299 - 2312, http://dx.doi.org/10.1210/en.2014-1884

Sutton-Mcdowall ML; Purdey M; Brown HM; Abell AD; Mottershead DG; Cetica PD; Dalvit GC; Goldys EM; Gilchrist RB; Gardner DK; Thompson JG, 2015, 'REDOX and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone', Molecular Reproduction and Development, vol. 82, pp. 281 - 294, http://dx.doi.org/10.1002/mrd.22470

Li JJ; Sugimura S; Mueller TD; White MA; Martin GA; Ritter LJ; Liang XY; Gilchrist RB; Mottershead DG, 2015, 'Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes', Molecular Endocrinology, vol. 29, pp. 40 - 52, http://dx.doi.org/10.1210/me.2014-1173

Machado MF; Caixeta ES; Sudiman J; Gilchrist RB; Thompson JG; Lima PF; Price CA; Buratini J, 2015, 'Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro-produced embryos in cattle', Theriogenology, vol. 84, pp. 390 - 398, http://dx.doi.org/10.1016/j.theriogenology.2015.03.031

Brown HM; Anastasi MR; Frank LA; Kind KL; Richani D; Robker RL; Russell DL; Gilchrist RB; Thompson JG, 2015, 'Hemoglobin: A gas transport molecule that is hormonally regulated in the ovarian follicle in mice and humans', Biology of Reproduction, vol. 92, http://dx.doi.org/10.1095/biolreprod.114.124594

Gilchrist RB; Zeng HT; Wang X; Richani D; Smitz J; Thompson JG, 2015, 'Reevaluation and evolution of the simulated physiological oocyte maturation system', Theriogenology, vol. 84, pp. 656 - 657, http://dx.doi.org/10.1016/j.theriogenology.2015.03.032

Spits C; Guzman L; Mertzanidou A; Jacobs K; Ortega-Hrepich C; Gilchrist RB; Thompson JG; De Vos M; Smitz J; Sermon K, 2015, 'Chromosome constitution of human embryos generated after in vitro maturation including 3-isobutyl-1-methylxanthine in the oocyte collection medium', Human Reproduction, vol. 30, pp. 653 - 663, http://dx.doi.org/10.1093/humrep/deu329

Mester B; Ritter LJ; Pitman JL; Bibby AH; Gilchrist RB; McNatty KP; Juengel JL; McIntosh CJ, 2015, 'Oocyte expression, secretion and somatic cell interaction of mouse bone morphogenetic protein 15 during the peri-ovulatory period', Reproduction, Fertility and Development, vol. 27, pp. 801 - 811, http://dx.doi.org/10.1071/RD13336

Gilchrist RB; Zeng HT; Wang X; Richani D; Smitz J; Thompson JG, 2015, 'Reevaluation and evolution of the simulated physiological oocyte maturation system', Theriogenology, http://dx.doi.org/10.1016/j.theriogenology.2015.03.032

Sudiman J; Sutton-McDowall ML; Ritter LJ; White MA; Mottershead DG; Thompson JG; Gilchrist RB, 2014, 'Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0103563

Simpson CM; Robertson DM; Al-Musawi SL; Heath DA; McNatty KP; Ritter LJ; Mottershead DG; Gilchrist RB; Harrison CA; Stanton PG, 2014, 'Aberrant GDF9 expression and activation are associated with common human ovarian disorders', Journal of Clinical Endocrinology and Metabolism, vol. 99, http://dx.doi.org/10.1210/jc.2013-3949

Richani D; Sutton-McDowall ML; Frank LA; Gilchrist RB; Thompson JG, 2014, 'Effect of epidermal growth factor-like peptides on the metabolism of in vitro-matured mouse oocytes and cumulus cells', Biology of Reproduction, vol. 90, http://dx.doi.org/10.1095/biolreprod.113.115311

Sugimura S; Ritter LJ; Sutton-McDowall ML; Mottershead DG; Thompson JG; Gilchrist RB, 2014, 'Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: Effects on gap junction-mediated metabolite supply', Molecular Human Reproduction, vol. 20, pp. 499 - 513, http://dx.doi.org/10.1093/molehr/gau013

Frank LA; Sutton-Mcdowall ML; Brown HM; Russell DL; Gilchrist RB; Thompson JG, 2014, 'Hyperglycaemic conditions perturb mouse oocyte in vitro developmental competence via beta-O-linked glycosylation of Heat shock protein 90', Human Reproduction, vol. 29, pp. 1292 - 1303, http://dx.doi.org/10.1093/humrep/deu066

Frank LA; Sutton-Mcdowall ML; Gilchrist RB; Thompson JG, 2014, 'The effect of peri-conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence', Molecular Reproduction and Development, vol. 81, pp. 391 - 408, http://dx.doi.org/10.1002/mrd.22299

Richani D; Wang X; Zeng HT; Smitz J; Thompson JG; Gilchrist RB, 2014, 'Pre-maturation with cAMP modulators in conjunction with EGF-like peptides during in vitro maturation enhances mouse oocyte developmental competence', Molecular Reproduction and Development, vol. 81, pp. 422 - 435, http://dx.doi.org/10.1002/mrd.22307

Sudiman J; Ritter LJ; Feil DK; Wang X; Chan K; Mottershead DG; Robertson DM; Thompson JG; Gilchrist RB, 2014, 'Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development', Journal of Assisted Reproduction and Genetics, vol. 31, pp. 295 - 306, http://dx.doi.org/10.1007/s10815-013-0152-5

Zeng HT; Richani D; Sutton-McDowall ML; Ren Z; Smitz JEJ; Stokes Y; Gilchrist RB; Thompson JG, 2014, 'Prematuration with cyclic adenosine monophosphate modulators alters cumulus cell and oocyte metabolism and enhances developmental competence of in vitro- matured mouse oocytes', Biology of Reproduction, vol. 91, http://dx.doi.org/10.1095/biolreprod.114.118471

Santiquet N; Sasseville M; Laforest M; Guillemette C; Gilchrist RB; Richard FJ, 2014, 'Activation of 5' adenosine monophosphate-activated protein kinase blocks cumulus cell expansion through inhibition of protein synthesis during in vitro maturation in swine', Biology of Reproduction, vol. 91, http://dx.doi.org/10.1095/biolreprod.113.116764

Machado MF; Nogueira MF; Gilchrist RB; Sutton-McDowall ML; Mottershead DG; White MA; Thompson JG, 2014, '236 effect of cyclic adenosine monophosphate modulator regulators in association with bmp15 on bovine embryo development in vitro.', Reprod Fertil Dev, vol. 27, pp. 207 - 208, http://dx.doi.org/10.1071/RDv27n1Ab236

Gilchrist RB; Richani D, 2013, 'Somatic guidance for the oocyte', Developmental Cell, vol. 27, pp. 603 - 605, http://dx.doi.org/10.1016/j.devcel.2013.12.006

Thompson JG; Gilchrist RB, 2013, 'Pioneering contributions by Robert Edwards to oocyte in vitro maturation (IVM)', Molecular Human Reproduction, vol. 19, pp. 794 - 798, http://dx.doi.org/10.1093/molehr/gat075

Frank LA; Sutton-Mcdowall ML; Russell DL; Wang X; Feil DK; Gilchrist RB; Thompson JG, 2013, 'Effect of varying glucose and glucosamine concentration in vitro on mouse oocyte maturation and developmental competence', Reproduction, Fertility and Development, vol. 25, pp. 1095 - 1104, http://dx.doi.org/10.1071/RD12275

Richani D; Ritter LJ; Thompson JG; Gilchrist RB, 2013, 'Mode of oocyte maturation affects EGF-like peptide function and oocyte competence', Molecular Human Reproduction, vol. 19, pp. 500 - 509, http://dx.doi.org/10.1093/molehr/gat028

Caixeta ES; Sutton-McDowall ML; Gilchrist RB; Thompson JG; Price CA; Machado MF; Lima PF; Buratini J, 2013, 'Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus-oocyte complexes', Reproduction, vol. 146, pp. 27 - 35, http://dx.doi.org/10.1530/REP-13-0079

Mottershead DG; Harrison CA; Mueller TD; Stanton PG; Gilchrist RB; McNatty KP, 2013, 'Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, http://dx.doi.org/10.1073/pnas.1303459110

Thompson JG; Mottershead DG; Gilchrist RB, 2013, 'Oocyte-Secreted Factors in Domestic Animals', Oocyte Physiology and Development in Domestic Animals, pp. 55 - 70, http://dx.doi.org/10.1002/9781118538074.ch4

Zeng HT; Ren Z; Guzman L; Wang X; Sutton-Mcdowall ML; Ritter LJ; De Vos M; Smitz J; Thompson JG; Gilchrist RB, 2013, 'Heparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence', Human Reproduction, vol. 28, pp. 1536 - 1545, http://dx.doi.org/10.1093/humrep/det086

Rose RD; Gilchrist RB; Kelly JM; Thompson JG; Sutton-McDowall ML, 2013, 'Regulation of sheep oocyte maturation using cAMP modulators', Theriogenology, vol. 79, pp. 142 - 148, http://dx.doi.org/10.1016/j.theriogenology.2012.09.020

Sutton-Mcdowall ML; Mottershead DG; Gardner DK; Gilchrist RB; Thompson JG, 2012, 'Metabolic differences in bovine cumulus-oocyte complexes matured in vitro in the presence or absence of follicle-stimulating hormone and bone morphogenetic protein 15', Biology of Reproduction, vol. 87, http://dx.doi.org/10.1095/biolreprod.112.102061

Watson LN; Mottershead DG; Dunning KR; Robker RL; Gilchrist RB; Russell DL, 2012, 'Heparan sulfate proteoglycans regulate responses to oocyte paracrine signals in ovarian follicle morphogenesis', Endocrinology, vol. 153, pp. 4544 - 4555, http://dx.doi.org/10.1210/en.2012-1181

Sharkey DJ; Macpherson AM; Tremellen KP; Mottershead DG; Gilchrist RB; Robertson SA, 2012, 'TGF-β mediates proinflammatory seminal fluid signaling in human cervical epithelial cells', Journal of Immunology, vol. 189, pp. 1024 - 1035, http://dx.doi.org/10.4049/jimmunol.1200005

Mottershead DG; Ritter LJ; Gilchrist RB, 2012, 'Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15', Molecular Human Reproduction, vol. 18, pp. 121 - 128, http://dx.doi.org/10.1093/molehr/gar056

Simpson CM; Stanton PG; Walton KL; Chan KL; Ritter LJ; Gilchrist RB; Harrison CA, 2012, 'Activation of latent human GDF9 by a single residue change (Gly ³⁹¹Arg) in the mature domain', Endocrinology, vol. 153, pp. 1301 - 1310, http://dx.doi.org/10.1210/en.2011-1632

Gilchrist RB; Ritter LJ, 2011, 'Differences in the participation of TGFB superfamily signalling pathways mediating porcine and murine cumulus cell expansion', Reproduction, vol. 142, pp. 647 - 657, http://dx.doi.org/10.1530/REP-11-0196

Gilchrist RB; De Vos M; Smitz J; Thompson JG, 2011, 'IVM media are designed specifically to support immature cumulus-oocyte complexes not denuded oocytes that have failed to respond to hyperstimulation', Fertility and Sterility, vol. 96, http://dx.doi.org/10.1016/j.fertnstert.2011.06.012

Scaramuzzi RJ; Baird DT; Campbell BK; Driancourt MA; Dupont J; Fortune JE; Gilchrist RB; Martin GB; McNatty KP; McNeilly AS; Monget P; Monniaux D; Viñoles C; Webb R, 2011, 'Regulation of folliculogenesis and the determination of ovulation rate in ruminants', Reproduction, Fertility and Development, vol. 23, pp. 444 - 467, http://dx.doi.org/10.1071/RD09161

Hussein TS; Sutton-Mcdowall ML; Gilchrist RB; Thompson JG, 2011, 'Temporal effects of exogenous oocyte-secreted factors on bovine oocyte developmental competence during IVM', Reproduction, Fertility and Development, vol. 23, pp. 576 - 584, http://dx.doi.org/10.1071/RD10323

Smitz JEJ; Thompson JG; Gilchrist RB, 2011, 'The promise of in vitro maturation in assisted reproduction and fertility preservation', Seminars in Reproductive Medicine, vol. 29, pp. 24 - 37, http://dx.doi.org/10.1055/s-0030-1268701

Gilchrist RB, 2011, 'Recent insights into oocytefollicle cell interactions provide opportunities for the development of new approaches to in vitro maturation', Reproduction, Fertility and Development, vol. 23, pp. 23 - 31, http://dx.doi.org/10.1071/RD10225

Sasseville M; Ritter LJ; Nguyen TM; Liu F; Mottershead DG; Russell DL; Gilchrist RB, 2010, 'Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells', Journal of Cell Science, vol. 123, pp. 3166 - 3176, http://dx.doi.org/10.1242/jcs.063834

Sutton-McDowall ML; Gilchrist RB; Thompson JG, 2010, 'The pivotal role of glucose metabolism in determining oocyte developmental competence', Reproduction, vol. 139, pp. 685 - 695, http://dx.doi.org/10.1530/REP-09-0345

Albuz FK; Sasseville M; Lane M; Armstrong DT; Thompson JG; Gilchrist RB, 2010, 'Simulated physiological oocyte maturation (SPOM): A novel in vitro maturation system that substantially improves embryo yield and pregnancy outcomes', Human Reproduction, vol. 25, pp. 2999 - 3011, http://dx.doi.org/10.1093/humrep/deq246

Wang Y; Nicholls PK; Stanton PG; Harrison CA; Sarraj M; Gilchrist RB; Findlay JK; Farnworth PG, 2009, 'Extra-ovarian expression and activity of growth differentiation factor 9', Journal of Endocrinology, vol. 202, pp. 419 - 430, http://dx.doi.org/10.1677/JOE-08-0563

Sasseville M; Albuz FK; Côté N; Guillemette C; Gilchrist RB; Richard FJ, 2009, 'Characterization of novel phosphodiesterases in the bovine ovarian follicle', Biology of Reproduction, vol. 81, pp. 415 - 425, http://dx.doi.org/10.1095/biolreprod.108.074450

Nicholls PK; Harrison CA; Gilchrist RB; Farnworth PG; Stanton PG, 2009, 'Growth differentiation factor 9 is a germ cell regulator of sertoli cell function', Endocrinology, vol. 150, pp. 2481 - 2490, http://dx.doi.org/10.1210/en.2008-1048

Sasseville M; Gagnon MC; Guillemette C; Sullivan R; Gilchrist RB; Richard FJ, 2009, 'Regulation of gap junctions in porcine cumulus-oocyte complexes: contributions of granulosa cell contact, gonadotropins, and lipid rafts', Molecular Endocrinology, vol. 23, pp. 700 - 710, http://dx.doi.org/10.1210/me.2008-0320

Yeo CX; Gilchrist RB; Lane M, 2009, 'Disruption of bidirectional oocyte-cumulus paracrine signaling during in vitro maturation reduces subsequent mouse oocyte developmental competence', Biology of Reproduction, vol. 80, pp. 1072 - 1080, http://dx.doi.org/10.1095/biolreprod.108.073908

Gilchrist RB; Lane M; Thompson JG, 2008, 'Oocyte-secreted factors: Regulators of cumulus cell function and oocyte quality', Human Reproduction Update, vol. 14, pp. 159 - 177, http://dx.doi.org/10.1093/humupd/dmm040

Lekamge DN; Lane M; Gilchrist RB; Tremellen KP, 2008, 'Increased gonadotrophin stimulation does not improve IVF outcomes in patients with predicted poor ovarian reserve', Journal of Assisted Reproduction and Genetics, vol. 25, pp. 515 - 521, http://dx.doi.org/10.1007/s10815-008-9266-6

Yeo CX; Gilchrist RB; Thompson JG; Lane M, 2008, 'Exogenous growth differentiation factor 9 in oocyte maturation media enhances subsequent embryo development and fetal viability in mice', Human Reproduction, vol. 23, pp. 67 - 73, http://dx.doi.org/10.1093/humrep/dem140

Grupen CG; Gilchrist RB; Nayudu PL; Barry MF; Schulz SJ; Ritter LJ; Armstrong DT, 2007, 'Effects of ovarian stimulation, with and without human chorionic gonadotrophin, on oocyte meiotic and developmental competence in the marmoset monkey (Callithrix jacchus)', Theriogenology, vol. 68, pp. 861 - 872, http://dx.doi.org/10.1016/j.theriogenology.2007.07.009

Dragovic RA; Ritter LJ; Schulz SJ; Amato F; Thompson JG; Armstrong DT; Gilchrist RB, 2007, 'Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion', Biology of Reproduction, vol. 76, pp. 848 - 857, http://dx.doi.org/10.1095/biolreprod.106.057471

Mayes MA; Laforest MF; Guillemette C; Gilchrist RB; Richard FJ, 2007, 'Adenosine 5′-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes', Biology of Reproduction, vol. 76, pp. 589 - 597, http://dx.doi.org/10.1095/biolreprod.106.057828

Prasad S; Humphreys I; Kireta S; Gilchrist RB; Bardy P; Russ GR; Coates PTH, 2007, 'The common marmoset as a novel preclinical transplant model: Identification of new MHC class II DRB alleles and prediction of in vitro alloreactivity', Tissue Antigens, vol. 69, pp. 72 - 75, http://dx.doi.org/10.1111/j.1399-0039.2006.760_7.x

Thompson JG; Lane M; Gilchrist RB, 2007, 'Metabolism of the bovine cumulus-oocyte complex and influence on subsequent developmental competence.', Society of Reproduction and Fertility supplement, vol. 64, pp. 179 - 190

Lekamge DN; Barry M; Kolo M; Lane M; Gilchrist RB; Tremellen KP, 2007, 'Anti-Müllerian hormone as a predictor of IVF outcome', Reproductive BioMedicine Online, vol. 14, pp. 602 - 610, http://dx.doi.org/10.1016/S1472-6483(10)61053-X

Gilchrist RB; Thompson JG, 2007, 'Oocyte maturation: Emerging concepts and technologies to improve developmental potential in vitro', Theriogenology, vol. 67, pp. 6 - 15, http://dx.doi.org/10.1016/j.theriogenology.2006.09.027

Gilchrist RB; Ritter LJ; Myllymaa S; Kaivo-Oja N; Dragovic RA; Hickey TE; Ritvos O; Mottershead DG, 2006, 'Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation', Journal of Cell Science, vol. 119, pp. 3811 - 3821, http://dx.doi.org/10.1242/jcs.03105

Hussein TS; Thompson JG; Gilchrist RB, 2006, 'Oocyte-secreted factors enhance oocyte developmental competence', Developmental Biology, vol. 296, pp. 514 - 521, http://dx.doi.org/10.1016/j.ydbio.2006.06.026

Prasad S; Humphreys I; Kireta S; Gilchrist RB; Bardy P; Russ GR; Coates PTH, 2006, 'MHC Class II DRB genotyping is highly predictive of in-vitro alloreactivity in the common marmoset', Journal of Immunological Methods, vol. 314, pp. 153 - 163, http://dx.doi.org/10.1016/j.jim.2006.06.009

Sutton-McDowall ML; Mitchell M; Cetica P; Dalvit G; Pantaleon M; Lane M; Gilchrist RB; Thompson JG, 2006, 'Glucosamine supplementation during in vitro maturation inhibits subsequent embryo development: Possible role of the hexosamine pathway as a regulator of developmental competence', Biology of Reproduction, vol. 74, pp. 881 - 888, http://dx.doi.org/10.1095/biolreprod.105.048553

Hussein TS; Froiland DA; Amato F; Thompson JG; Gilchrist RB, 2005, 'Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins', Journal of Cell Science, vol. 118, pp. 5257 - 5268, http://dx.doi.org/10.1242/jcs.02644

Hickey TE; Marrocco DL; Amato F; Ritter LJ; Norman RJ; Gilchrist RB; Armstrong DT, 2005, 'Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells', Biology of Reproduction, vol. 73, pp. 825 - 832, http://dx.doi.org/10.1095/biolreprod.104.039362

Kireta S; Zola H; Gilchrist RB; Coates PTH, 2005, 'Cross-reactivity of anti-human chemokine receptor and anti-TNF family antibodies with common marmoset (Callithrix jacchus) leukocytes', Cellular Immunology, vol. 236, pp. 115 - 122, http://dx.doi.org/10.1016/j.cellimm.2005.08.017

Sutton-McDowall ML; Gilchrist RB; Thompson JG, 2005, 'Effect of hexoses and gonadotrophin supplementation on bovine oocyte nuclear maturation during in vitro maturation in a synthetic follicle fluid medium', Reproduction, Fertility and Development, vol. 17, pp. 407 - 415, http://dx.doi.org/10.1071/RD04135

Dragovic RA; Ritter LJ; Schulz SJ; Amato F; Armstrong DT; Gilchrist RB, 2005, 'Role of oocyte-secreted growth differentiation factor 9 in the regulation of mouse cumulus expansion', Endocrinology, vol. 146, pp. 2798 - 2806, http://dx.doi.org/10.1210/en.2005-0098

Kaivo-Oja N; Mottershead DG; Mazerbourg S; Myllymaa S; Duprat S; Gilchrist RB; Groome NP; Hsueh AJ; Ritvos O, 2005, 'Adenoviral gene transfer allows Smad-responsive gene promoter analyses and delineation of type I receptor usage of transforming growth factor-β family ligands in cultured human granulosa luteal cells', Journal of Clinical Endocrinology and Metabolism, vol. 90, pp. 271 - 278, http://dx.doi.org/10.1210/jc.2004-1288

Thomas RE; Thompson JG; Armstrong DT; Gilchrist RB, 2004, 'Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity', Biology of Reproduction, vol. 71, pp. 1142 - 1149, http://dx.doi.org/10.1095/biolreprod.103.024828

Sutton-McDowall ML; Gilchrist RB; Thompson JG, 2004, 'Cumulus expansion and glucose utilisation by bovine cumulus-oocyte complexes during in vitro maturation: The influence of glucosamine and follicle-stimulating hormone', Reproduction, vol. 128, pp. 313 - 319, http://dx.doi.org/10.1530/rep.1.00225

Gilchrist RB; Ritter LJ; Cranfield M; Jeffery LA; Amato F; Scott SJ; Myllymaa S; Kaivo-Oja N; Lankinen H; Mottershead DG; Groome NP; Ritvos O, 2004, 'Immunoneutralization of growth differentiation factor 9 reveals it partially accounts for mouse oocyte mitogenic activity', Biology of Reproduction, vol. 71, pp. 732 - 739, http://dx.doi.org/10.1095/biolreprod.104.028852

Hickey TE; Marrocco DL; Gilchrist RB; Norman RJ; Armstrong DT, 2004, 'Interactions between androgen and growth factors in granulosa cell subtypes of porcine antral follicles', Biology of Reproduction, vol. 71, pp. 45 - 52, http://dx.doi.org/10.1095/biolreprod.103.026484

Gilchrist RB; Ritter LJ; Armstrong DT, 2004, 'Oocyte-somatic cell interactions during follicle development in mammals', Animal Reproduction Science, vol. 82-83, pp. 431 - 446, http://dx.doi.org/10.1016/j.anireprosci.2004.05.017

Thomas RE; Armstrong DT; Gilchrist RB, 2004, 'Bovine Cumulus Cell-Oocyte Gap Junctional Communication during In Vitro Maturation in Response to Manipulation of Cell-Specific Cyclic Adenosine 3′,5′-Monophosophate Levels', Biology of Reproduction, vol. 70, pp. 548 - 556, http://dx.doi.org/10.1095/biolreprod.103.021204

Sutton ML; Cetica PD; Beconi MT; Kind KL; Gilchrist RB; Thompson JG, 2003, 'Influence of oocyte-secreted factors and culture duration on the metabolic activity of bovine cumulus cell complexes', Reproduction, vol. 126, pp. 27 - 34, http://dx.doi.org/10.1530/rep.0.1260027

Gilchrist RB; Morrissey MP; Ritter LJ; Armstrong DT, 2003, 'Comparison of oocyte factors and transforming growth factor-β in the regulation of DNA synthesis in bovine granulosa cells', Molecular and Cellular Endocrinology, vol. 201, pp. 87 - 95, http://dx.doi.org/10.1016/S0303-7207(02)00429-X

Sutton ML; Gilchrist RB; Thompson JG, 2003, 'Effect of in-vivo and in-vitro environments on the metabolism of the cumulus-oocyte complex and its influence on oocyte developmental capacity', Human Reproduction Update, vol. 9, pp. 35 - 48, http://dx.doi.org/10.1093/humupd/dmg009

Thomas RE; Armstrong DT; Gilchrist RB, 2002, 'Differential effects of specific phosphodiesterase isoenzyme inhibitors on bovine oocyte meiotic maturation', Developmental Biology, vol. 244, pp. 215 - 225, http://dx.doi.org/10.1006/dbio.2002.0609

Ryan NK; Woodhouse CM; Van der Hoek KH; Gilchrist RB; Armstrong DT; Norman RJ, 2002, 'Expression of leptin and its receptor in the murine ovary: Possible role in the regulation of oocyte maturation', Biology of Reproduction, vol. 66, pp. 1548 - 1554, http://dx.doi.org/10.1095/biolreprod66.5.1548

Gilchrist RB; Ritter LJ; Armstrong DT, 2001, 'Mouse oocyte mitogenic activity is developmentally coordinated throughout folliculogenesis and meiotic maturation', Developmental Biology, vol. 240, pp. 289 - 298, http://dx.doi.org/10.1006/dbio.2001.0451

Gilchrist RB; Wicherek M; Heistermann M; Nayudu PL; Hodges JK, 2001, 'Changes in follicle-stimulating hormone and follicle populations during the ovarian cycle of the common marmoset', Biology of Reproduction, vol. 64, pp. 127 - 135, http://dx.doi.org/10.1095/biolreprod64.1.127

Gilchrist RB; Rowe DB; Ritter LJ; Robertson SA; Norman RJ; Armstrong DT, 2000, 'Effect of granulocyte-macrophage colony-stimulating factor deficiency on ovarian follicular cell function', Journal of Reproduction and Fertility, vol. 120, pp. 283 - 292, http://dx.doi.org/10.1530/jrf.0.1200283

Li R; Norman RJ; Armstrong DT; Gilchrist RB, 2000, 'Oocyte-secreted factor(s) determine functional differences between bovine mural granulosa cells and cumulus cells', Biology of Reproduction, vol. 63, pp. 839 - 845, http://dx.doi.org/10.1095/biolreprod63.3.839

Gilchrist RB; Nayudu PL; Hodges JK, 1997, 'Maturation, fertilization, and development of marmoset monkey oocytes in vitro', Biology of Reproduction, vol. 56, pp. 238 - 246, http://dx.doi.org/10.1095/biolreprod56.1.238

Gilchrist RB; Nayudu PL; Nowshari MA; Hodges JK, 1995, 'Meiotic competence of marmoset monkey oocytes is related to follicle size and oocyte-somatic cell associations', Biology of Reproduction, vol. 52, pp. 1234 - 1243, http://dx.doi.org/10.1095/biolreprod52.6.1234

Conference Papers

Riepsamen A; Gilchrist R; Ledger W, 2019, 'Oocyte-secreted serum biomarkers and reproductive potential in women', in Oocyte-secreted serum biomarkers and reproductive potential in women, Oxford University Press, Vienna, pp. i21 - i21, presented at 35th Annual Meeting of the European Society of Human Reproduction and Embryology, Vienna, 23 June 2019 - 26 June 2019, http://dx.doi.org/10.1093/humrep/34.Supplement_1.1

Gilchrist R; Richani D; Sugimura S, 2018, 'Follicular guidance for oocyte developmental competence', in Proceedings of the 10th International Ruminant Reproduction Symposium (IRRS 2018), BRAZILIAN COLL ANIMAL REPRODUCTION, Foz do Iguacu, Brazil, pp. 721 - 726, presented at 10th International Ruminant Reproduction Symposium (IRRS 2018);, Foz do Iguacu, Brazil, 26 September 2018 - 20 September 2018, http://dx.doi.org/10.21451/1984-3143-AR2018-0035

Riepsamen AH; Robertson DM; Chan K; Sweeten P; Agapiou D; Garrett D; Anazodo A; Walton K; Harrison C; Gilchrist RB; Ledger WL, 2017, 'Serum levels of the oocyte-secreted factors GDF9 and BMP15 are associated with reproductive potential in women', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, Geneva, SWITZERLAND, pp. 105 - 105, presented at 33rd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Geneva, SWITZERLAND, 02 July 2017 - 05 July 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416390501022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gook DA; Gilchrist RB; Thompson JG; Mottershead DG; Edgar DH, 2015, 'Maturation of human oocytes obtained from small antral follicles during processing of ovarian tissue for cryopreservation.', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, Lisbon, PORTUGAL, pp. 319 - 320, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Lisbon, PORTUGAL, 14 June 2015 - 17 June 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359740302128&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Albuz FK; Guzman L; Ortega C; Gilchrist RB; Devroey P; De Vos M; Smitz J, 2011, 'The developmental capacity of human in vitro matured oocytes retrieved from small antral follicles (4-6 mm) in non-hCG-primed cycles', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, Stockholm, SWEDEN, pp. I177 - I177, presented at 27th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology, Stockholm, SWEDEN, 03 July 2011 - 06 July 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000294450500440&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Working Papers

Bertoldo M; Listijono D; Ho W-HJ; Riepsamen A; Jin X; Selesniemi K; Goss D; Mahbub S; Campbell J; Habibalahi A; Loh W-GN; Youngson N; Maniam J; Wong ASA; Richani D; Li C; Zhao Y; Marinova M; Kim L-J; Lau L; Wu R; Mikolaizak S; Araki T; Le Couteur D; Turner N; Morris M; Walters K; Goldys E; O’Neill C; Gilchrist R; Sinclair D; Homer H; Wu L, 2019, NAD+ repletion rescues female fertility during reproductive ageing, http://dx.doi.org/10.1101/721985

School of Women's and Children's Health

Professor Robert Gilchrist

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