Research areas in Women's Cancer
The overall aim of the Metastasis Research group is to understand the key processes in epithelial to mesenchymal transition (EMT) and cancer metastasis, in order to identify targets for novel therapies.
This group focuses on an important signalling pathway involved in metastasis, the Wnt signalling pathway. They are particularly interested in investigating the regulation of a number of key proteins involved in this pathway, and understanding their role in the context of ovarian, endometrial and breast cancer.
The group is leda by Dr Caroline Ford, a cancer researcher within the School of Women's and Children's Health and based at the Lowy Cancer Research Centre. After completing her PhD at UNSW on the topic of oncogenic viruses, Dr Ford undertook two international postdoctoral appointments in cancer research. Her first postdoctoral research appointment was at the University of Toronto, Canada and the second appointment was at Lund University, Sweden. She returned to UNSW in late 2009 funded by an NHMRC CJ Martin Fellowship and established the Metastasis Research group.
Dr Ford is also an experienced university lecturer, convening courses on medical research, cancer pathology and personalised medicine, including Australia's first MOOC (Massive Open Online Course) on Personalised Medicine. She has completed a Graduate Certificate in University Learning & Teaching, and is passionate about science communication and enhancing the health literacy of the wider community.
Current and future projects include:
- 3D model of ovarian cancer metastasis
- A search for a “Wnt signature” in gynaecological cancers
- Expression and function of Wnt receptors in endometrial cancer
- The effect of Wnt inhibitors on ROR1 and ROR2 signalling using a novel ascites tumour model
Ms Claire Henry
Ms Marilisa Cortesi
The Metastasis Research group provides opportunities for Honours students and PhD students.
We also take a number of Medical School students each year for ILP projects.
As a first point-of-contact please contact Dr Caroline Ford firstname.lastname@example.org.
The Molecular Oncology Group participates in two large international consortia investigating genetic susceptibility to breast and ovarian cancer. The group also co-leads an international consortium studying ovarian tumours to identify clinically relevant biomarkers. In addition the group coordinates the centralised sample repository for these consortia for sequencing, genotyping and tumour profiling and performs high throughput experiments using the latest genomics technologies.
Read more about Prof Ramus and her research: World leading ovarian cancer researcher joins UNSW Medicine